Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: a Systematic Review and Meta-analysis

Cui, Xiaobin; Peng, Hao; Su, Li; Li, Tingting; Liu, Chunxia; Zhang, Shumao; Jin, Tingting; Hu, Jianming; Jiang, Jinfang; Liang, Wenjie; Li, Na; Li, Li; Chen, Yunzhao; Li, Feng

doi:10.7314/apjcp.2014.15.22.9661

Cited by 17 publications

(9 citation statements)

References 38 publications

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“…High PLCE1 expression is correlated with poor prognosis of ESCC patients, suggesting that PLCE1 is a potential biomarker for ESCC diagnosis and treatment. The present findings are consistent with those of Wang et al [ 7 ] and previous meta-analysis on PLCE1 protein expression in upper gastrointestinal cancer [ 45 ], as well as in other human malignancies, such as gastric [ 14 ] and bladder cancer [ 17 ]. However, the elevated PLCE1 protein expression patterns in ESCC differ from those reported by Hu et al [ 23 ], who found no difference in PLCE1 IHC scores between ESCC and the matching adjacent normal tissues.…”

Section: Discussionsupporting

confidence: 94%

Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma

Cui

et al. 2015

Oncotarget

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Phospholipase C epsilon 1 (PLCE1) is a susceptibility gene in esophageal squamous cell carcinoma (ESCC). Nevertheless, the role of PLCE1 in ESCC tumorigenesis has not been elucidated. In this study, we determined the function of PLCE1 and its regulatory microRNA (miRNA) in ESCC. PLCE1 protein was excessively expressed in ESCC and precancerous lesions compared with that in normal tissues. High PLCE1 expression levels in ESCC were significantly linked with poor overall survival. Knockdown of PLCE1 promoted the apoptosis, cytokine-induced apoptosis, and sensitivity of cancer cells to chemotherapeutic drugs but abrogated the proliferation and EMT phenotype of ESCC in vitro. Notably, miR-145 was newly identified as a potent repressor of PLCE1 expression by directly targeting the 3′UTR of PLCE1. MiR-145 also inhibited cell proliferation, migration, and metastasis, as well as controlled the cytoskeleton dynamics of esophageal cancer. Moreover, miR-145 was expressed at low levels in a large cohort of patients with ESCC and was inversely correlated with PLCE1 protein expression in cancer cells and tissues. These findings demonstrate that PLCE1 functions as tumor promoter in ESCC and can be suppressed by miR-145 through inhibition of PLCE1 translation. Hence, delivery of PLCE1-targeting miR-145 is a potential therapeutic approach for esophageal cancer.

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Section: Discussionsupporting

confidence: 94%

Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma

Cui

et al. 2015

Oncotarget

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“…NDC80, PLCE1 and AKAP13 have so far not been studied in melanoma. However, in several other cancers their expression was linked to a worsened prognosis252627282930. These findings are also complemented by the use of the drug colcemid, which interferes with mitotic spindle formation.…”

Section: Discussionmentioning

confidence: 99%

Generation of metastatic melanoma specific antibodies by affinity purification

Schütz

Koppensteiner

Schörghofer

et al. 2016

Sci Rep

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Melanoma is the most aggressive type of skin cancer and one of the most frequent tumours in young adults. Identification of primary tumours prone to develop metastasis is of paramount importance for further patient stratification. However, till today, no markers exist that are routinely used to predict melanoma progression. To ameliorate this problem, we generated antiserum directed against metastatic melanoma tissue lysate and applied a novel approach to purify the obtained serum via consecutive affinity chromatography steps. The established antibody, termed MHA-3, showed high reactivity against metastatic melanoma cell lines both in vitro and in vivo. We also tested MHA-3 on 227 melanoma patient samples and compared staining with the melanoma marker S100b. Importantly, MHA-3 was able to differentiate between metastatic and non-metastatic melanoma samples. By proteome analysis we identified 18 distinct antigens bound by MHA-3. Combined expression profiling of all identified proteins revealed a significant survival difference in melanoma patients. In conclusion, we developed a polyclonal antibody, which is able to detect metastatic melanoma on paraffin embedded sections. Hence, we propose that this antibody will represent a valuable additional tool for precise melanoma diagnosis.

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“…In 2014 the same SNPs were proved to be associated with gastric cancer development in Korean population (cancer: n=3245; control n=1700) 32, 45. Finally, as it was above discussed, Cui et al and then Xue and coauthors conducted a large meta-analysis and summarized that PLCε could be a biomarker for ESCC and gastric adenocarcinoma 27, 35.…”

Section: Digestive Tract Cancersmentioning

confidence: 92%

“…Meta-analysis conducted by Cui and coauthors which included 761 esophageal and gastric cancer cases and 457 controls demonstrated a strong association of PLCE1 expression with tumor progression in esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC) 27.…”

Section: Digestive Tract Cancersmentioning

confidence: 99%

The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression

Tyutyunnykova¹,

Телегеев²,

Dubrovska³

2017

J. Cancer

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The phospholipase C (PLC) enzymes are important regulators of membrane phospholipid metabolism. PLC proteins can be activated by the receptor tyrosine kinases (RTK) or G-protein coupled receptors (GPCR) in response to the different extracellular stimuli including hormones and growth factors. Activated PLC enzymes hydrolyze phosphoinositides to increase the intracellular level of Ca2+ and produce diacylglycerol, which are important mediators of the intracellular signaling transduction. PLC family includes 13 isozymes belonging to 6 subfamilies according to their domain structures and functions. Although importance of PLC enzymes for key cellular functions is well established, the PLC proteins belonging to the ε, ζ and η subfamilies were identified and characterized only during the last decade. As a largest known PLC protein, PLCε is involved in a variety of signaling pathways and controls different cellular properties. Nevertheless, its role in carcinogenesis remains elusive.The aim of this review is to provide a comprehensive and up-to-date overview of the experimental and clinical data about the role of PLCε in the development and progression of the different types of human and experimental tumors.

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Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: a Systematic Review and Meta-analysis

Cited by 17 publications

References 38 publications

Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma

Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma

Generation of metastatic melanoma specific antibodies by affinity purification

The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression

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