Prognostic value of poorly differentiated carcinoma in Japanese Society of Thyroid Surgery in a series of papillary thyroid carcinoma patients: Comparison with risk classification system in Kuma Hospital

Abstract

PAPILLARY THYROID CARCINOMA (PTC) is the most common malignancy originating from the thyroid, and generally shows an indolent character. Abstract. Papillary thyroid carcinoma (PTC) often has poorly differentiated components, and it is discriminated from others and classified as an independent entity in the General Rules for the Description of Thyroid Cancer by Japanese Society of Thyroid Surgery (JSTS). In this study, we compared the prognostic significance between this type of poorly differentiated carcinoma (PDC-JSTS) and our risk classification system based on pre-and intraoperative findings in a series of PTC patients. The 10-year lymph node-and distant organ recurrence-free survival (LN-DFS and DRFS) and cause-specific survival (CSS) of high-risk patients were much poorer than in PDC-JSTS patients. In multivariate analysis, PDC-JSTS independently predicted a poor prognosis, but prognostic impacts for LN-DFS, DRFS, and CSS of high-risk in our risk classification were stronger than those of PDC-JSTS. In conclusion, it is appropriate that PDC-JSTS is defined as a subtype of PTC rather than as an independent entity.

The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

“…Based on our review, several cases had a multiconstituent histology of well-differentiated (mostly PTC and FTC) with poorly differentiated areas without elaborating on their extent [ 49 , 50 , 55 , 56 , 58 , 69 , 71 , 72 , 73 , 91 , 100 , 103 , 107 , 109 , 112 , 113 ]. Interestingly, the Japanese society of thyroid surgery emphasizes that the presence of a poorly differentiated component should be acknowledged as a distinct entity from DTC, independent of its histological extent within the tumor [ 128 ]. Studies have utilized the poorly differentiated proportion to distinguish PDTC and DTC with poorly differentiated areas, advocating its difference in terms of natural history and prognosis [ 91 ].…”

Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells

“…Papillary thyroid carcinoma sometimes contains poorly differentiated components and has an aggressive behavior and leads to a poor prognosis (1). However, the molecular mechanism remains unclear.…”