Prognostic value of serum CA-125 measurements on stimulation day 1 and on the day of oocyte pickup in the prediction of IVF treatment outcome

Hauzman, Erik; Lagarde, Ana R.; Nagy, Katalin; Fancsovits, Péter; Murber, Ákos; Jánoki, Győző A.; Papp, Zoltán; Urbancsek, János

doi:10.1007/s10815-005-5151-8

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Although we included women who underwent IVF treatment with or without ICSI, five studies excluded patients with endometriosis [12][13][14][15]17]. It is likely that Ca-125 concentrations are known to be elevated in endometriosis [18]; therefore, evidence related to the correlation between serum Ca-125 level in endometriosis and pregnant outcome is still lacking, which may reduce the overall applicability of the evidence.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 7 studies involving 558 patients were included, and the sample sizes of included studies were ranged from 33 to 182. Three studies directly reported mean and SD [11][12][13], while data for 4 studies [14-17] that did not were transformated according to the method proposed by Wan et al [10].Two studies detected serum Ca-125 by enzyme immunoassay method [15,17], while four studies [11,12,14,16] used…”

Section: Characteristics and Quality Assessment Of The Included Studiesmentioning

confidence: 99%

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The correlation between serum Ca-125 level and clinical pregnancy in in vitro fertilization (IVF): A meta-analysis

Wang

Zhang

et al. 2019

Preprint

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Background Several studies had investigated the role of serum Ca-125 in clinical pregnancy of patients undergoing in vitro fertilization (IVF); however, their conclusions had been inconsistent. This study aimed to evaluate the correlation between serum Ca-125 level and clinical pregnancy in IVF. MethodsWe systematically review the studies in the databases of Mediline OvidSP, EMBASE OvidSP and Cochrane (CENTRAL Central Register of Controlled Trials). Studies on the correlation between serum Ca-125 level and clinical pregnancy in patients underging IVF with or without Intracytoplasmic sperm injection (ICSI) were considered. The pooled standardized mean difference (SMD) with 95% confidence intervals (CIs) was used in the analysis.Results Seven studies involving 558 patients were included. The meta-analysis showed that there was no significant difference in the serum Ca-125 level before embryo transfer (ET) between clinical pregnant group and nonpregnant group (SMD 0.72; 95% CI [0.01, 1.43], P = 0.05, I 2 = 88%), and the same conclusion was also reached in patients without endometriosis (SMD 0.31; 95% CI [-0.53, 1.16], P = 0.47, I 2 = 89%); However, after embryo transfer, the result showed that the Ca-125 level has a small but significantly increase in the clinical pregnant group than in the nonpregnant group (SMD 0.39; 95% CI [0.09, 0.69], P = 0.01, I 2 = 0%).Conclusions Berore ET, there was no significant correlation between serum Ca-125 level and clinical pregnancy in IVF; After ET, the Ca-125 level has a small but significantly increase in the clinical pregnant group than in the nonpregnant group, and it might reflect a successful interaction between the embryo and the endometrium in that time period.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics and Quality Assessment Of The Included Studiesmentioning

confidence: 99%

The correlation between serum Ca-125 level and clinical pregnancy in in vitro fertilization (IVF): A meta-analysis

Wang

Zhang

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Several markers were studied previously in order to predict the pregnancy outcome of in vitro fertilisation (IVF) pregnancies, such as serum oestradiol, progesterone ( 6 ), CA-125 ( 7 ) or inhibin ( 8 ). However, beta human chorionic gonadotropin (β-hCG) was found to be the most predictive marker ( 9 , 10 , 11 , 12 , 13 ).…”

mentioning

confidence: 99%

Value of Post-transfer Day-12 Beta Human Chorionic Gonadotropin Levels for Pregnancy Outcome Prediction of Intracytoplasmic Sperm Injection Cycles

Kahyaoğlu¹,

Demır²,

Aksakal³

et al. 2017

Balkan Med J

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Background:Several markers were studied previously in order to predict the pregnancy outcome of assisted reproductive techniques; however, serum beta human chorionic gonadotropin was found title be the most predictive marker.Aims:To evaluate the value of serum beta human chorionic gonadotropin levels in discriminating biochemical and clinical pregnancies 12 days after embryo transfer, while determining the factors predicting ongoing pregnancy was established as the secondary aim.Study Design:Retrospective cross-sectional study.Methods:A total of 445 pregnant cycles were retrospectively analysed in 2359 embryo transfer cycles. Patients were divided into two groups according to the outcome of pregnanctitley: biochemical and clinical.Results:The cut-off value of beta human chorionic gonadotropin levels on day 12 in predicting clinical pregnancies was 86.8 IU/mL with 65.1% sensitivity and 74.7% specificity [CI: 0.76 (0.71-0.81). Receiver operating characteristic curve analysis revealed different cut-off values for embryo transfer days (57 mIU/mL for day 3 embryo transfer CI: 0.59-0.79 and 87 mIU/mL for day 5 embryo transfer, CI: 0.74-0.86). Subgroup analysis of clinical pregnancies revealed a significant difference between ongoing pregnancies and early fetal losses regarding duration of infertility (81.3±54.4 vs. 100.2±62.2 months), serum oestradiol on hCG day (2667.4±1276.4 vs. 2094.6±1260.5 pg/mL), number of transferred embryos (1.9±0.8 vs. 1.5±0.7) and the prevalence of diminished ovarian reserve as an indication (2.3% vs 12.2%).Conclusion:Beta human chorionic gonadotropin levels on day 12 following embryo transfer provide an important parameter for the prediction of clinical pregnancy; however, other stimulation parameters are indicated in the prediction of ongoing pregnancies.

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An in silico model using prognostic genetic factors for ovarian response in controlled ovarian stimulation: A systematic review

Eisele

Silva

Bessow

et al. 2021

J Assist Reprod Genet

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Prognostic value of serum CA-125 measurements on stimulation day 1 and on the day of oocyte pickup in the prediction of IVF treatment outcome

Cited by 4 publications

References 20 publications

The correlation between serum Ca-125 level and clinical pregnancy in in vitro fertilization (IVF): A meta-analysis

The correlation between serum Ca-125 level and clinical pregnancy in in vitro fertilization (IVF): A meta-analysis

Value of Post-transfer Day-12 Beta Human Chorionic Gonadotropin Levels for Pregnancy Outcome Prediction of Intracytoplasmic Sperm Injection Cycles

An in silico model using prognostic genetic factors for ovarian response in controlled ovarian stimulation: A systematic review

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