Prognostic value of the maximum standardized uptake value of pre-treatment primary lesions in small-cell lung cancer on 18F-FDG PET/CT: a meta-analysis

Zhu, Dongyong; Wang, Yanfang; Wang, Lisha; Chen, Jie; Byanju, Sama; Zhang, Hanfei; Liao, Meiyan

doi:10.1177/0284185117745907

Cited by 21 publications

(11 citation statements)

References 36 publications

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“…A recent meta-analysis demonstrated that the pre-treatment SUV Max in primary lesions can be an important prognostic factor for overall survival (OS) and event-free survival (EFS) in patients with SCLC. [20] According to the recent National Comprehensive Cancer Network (NCCN) guidelines, [21] the PET scan can increase staging accuracy in patients with SCLC, because SCLC is a highly metabolic disease. If limited-stage disease is suspected, a PET/CT scan can be performed to assess for distant metastases.…”

Section: Discussionmentioning

confidence: 99%

The role of 18F-FDG PET/CT in management of paraneoplastic limbic encephalitis combined with small cell lung cancer

Castagnoli

Manni

Marchesani³

et al. 2019

Medicine

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Rationale:Limbic encephalitis is one of the most common paraneoplastic neurological disorders (PND). The role of brain Fluorine-18-fluorodeoxyglucose position emission tomography/computed tomography (CT) in paraneoplastic limbic encephalitis (PLE) and of the whole body 18F-FDG PET/CT in this setting, remains still not well defined.Patient concerns:We report a case of a patient with chronic inflammatory rheumatism, psoriasis and Hashimoto thyroiditis and subsequent appearance of static and dynamic ataxia and episodic memory deficit who was diagnosed as PLE combined with small cell lung cancer (SCLC).Diagnoses:The diagnosis of SCLC was made with EBUS-TBNA of a mediastinal lymph node.Interventions:Whole-body 18F-FDG PET/CT was performed for the initial staging of SCLC, in the planning of radiotherapy treatment, to evaluate therapeutic response and in the follow-up. A dedicated brain scan was included to the same PET session. Whole-body contrast enhanced computed tomography (CT) and contrast enhanced whole-brain MRI were also performed.Outcomes:She was administered neoadjuvant chemioterapy with Cisplatin and Etoposide with concomitant radiotherapy treatment. Whole body 18F-FDG PET/CT showed a complete metabolic response already after 3 cycles of chemioterapy. Brain functional study showed a metabolic pattern characterized by the migration of hypermetabolism in the bilateral hippocampal areas during the therapeutic treatment, which correlated with the persistence of clinical symptoms.Lessons:In the era of personalized medicine and targeted therapy, this case highlights the importance of the 18F-FDG PET/CT study as an accurate tool to identify PLE and to guide the diagnostic work-up of the underlying tumor. Considering that most of these are 18F-FDG avid tumors and that the 18F-FDG PET/CT scan is often added to the diagnostic work-up when screening patients for malignancy, this functional imaging can play a decisive role.

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Section: Discussionmentioning

confidence: 99%

The role of 18F-FDG PET/CT in management of paraneoplastic limbic encephalitis combined with small cell lung cancer

Castagnoli

Manni

Marchesani³

et al. 2019

Medicine

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“…The National Comprehensive Cancer Network guidelines have recommended the application of 18 F-FDG PET/CT for SCLC patients (Johnson 2001 ). SUVmax measured on 18 F-FDG PET/CT is used to quantify FDG uptake of tumor cells; the degree of tumor uptake of 18 F-FDG on PET/CT is shown to be an valuable prognostic gauge in malignant tumors (Bai et al 2017 ; Hsieh et al 2018 ; Hsu et al 2016 ; Kwon et al 2016 ; Lee et al 2015 , 2018 ; Park et al 2014 , 2016 ; Zhu et al 2018 ). While, volumetric parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are investigated for independent prognostic parameters in NSCLC and some other cancers (Albano et al 2018 ; Burger et al 2016 ; Hasbek et al 2019 ; Lemarignier et al 2017 ; Tsujikawa et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer

Hui

Wei

Ren

et al. 2020

J Cancer Res Clin Oncol

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Purpose The combined small-cell lung cancer (c-SCLC) is rare and has unique clinicopathological futures. The aim of this study is to investigate 18 F-FDG PET/CT parameters and clinicopathological factors that influence the prognosis of c-SCLC. Methods Between November 2005 and October 2014, surgical-resected tumor samples from c-SCLC patients who received preoperative 18 F-FDG PET/CT examination were retrospectively reviewed. The maximum standardized uptake value (SUV max), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were used to evaluate metabolic parameters in primary tumors. The survivals were evaluated with the Kaplan-Meier method. Univariate and multivariate analyses were used to evaluate potential prognostic factors. Results Thirty-one patients were enrolled, with a median age of 62 (range: 35 − 79) years. The most common mixed component was squamous cell carcinoma (SCC, n = 12), followed by large-cell carcinoma (LCC, n = 7), adenocarcinoma (AC, n = 6), spindle cell carcinoma (n = 4), adenosquamous carcinoma (n = 1) and atypical carcinoid (n = 1). The median follow-up period was 53.0 (11.0-142.0) months; the 5-year overall survival (OS) and progression-free survival(PFS) rate were 48.4% and 35.5%, respectively. Univariate survival analysis showed that gender, smoking history, tumor location were associated with PFS (P = 0.036, P = 0.043, P = 0.048), SUVmax and TNM stage were closely related to PFS in both Mixed SCC and non-SCC component groups (P = 0.007, P = 0.048). SUV max , smoking history, tumor size and mixed SCC component were influencing factors of OS in patients (P = 0.040, P = 0.041, P = 0.046, P = 0.029). Multivariate survival analysis confirmed that TNM stage (HR = 2.885, 95%CI: 1.323-6.289, P = 0.008) was the most significantly influential factor for PFS. High SUV max value (HR = 9.338, 95%CI: 2.426-35.938, P = 0.001) and mixed SCC component (HR = 0.155, 95%CI: 0.045-0.530, P = 0.003) were poor predictors for OS. Conclusion Surgical-resected c-SCLCs have a relatively good prognosis. TNM stage is the most significant factor influencing disease progression in surgical-resected c-SCLCs. SUVmax and mixed NSCLC components within c-SCLCs had a considerable influence on the survival. Both high SUVmax and mixed SCC component are poor predictors for patients with c-SCLCs.

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“…The 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography-computed tomography (PET/CT) has been widely used in the diagnosis, staging and therapeutic evaluation of various malignancies. [16,17] Also, the prognostic prediction value in PDAC was reported by several researchers. [18–20] For resected PDAC patients, 18 F-FDG PET/CT metabolic parameters maximum standardized uptake values (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were illustrated to strongly correlate with OS and progression-free survival (PFS).…”

Section: Introductionmentioning

confidence: 99%

Prognostic values of 18F-FDG PET/CT metabolic parameters and clinical figures in locally advanced pancreatic cancer underwent chemotherapy combined with stereotactic body radiation therapy

Zhang

Ren²,

Yuan³

et al. 2019

Medicine

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Stereotactic body radiation therapy (SBRT) has emerged to be a preference treatment for locally advanced pancreatic cancer (LAPC) patients. In this study, we aimed to investigate the prognostic roles of 18 F-FDG PET/CT metabolic parameters and clinical figures in LAPC patients underwent chemo-SBRT combined therapy. During January 2013 to January 2017, 23 LAPC patients who underwent 18 F-FDG PET/CT within 2 weeks before treatment were recruited and retrospectively analyzed. Maximum standardized uptake values (SUVmax), SUVmean, metabolic tumor volume (MTV), total lesion glycolysis (TLG), chemoradiotherapy (CRT) sequence, and relevant clinical figures were grouped upon the median values, then analyzed by Kaplan–Meier method and Cox proportional hazard models for their prognostic evaluation. The median overall survival (OS) and progression-free survival (PFS) of all patients were 16.7 months and 11.3 months, respectively. According to the statistic results, the longest diameter of tumor (LDT), MTV, TLG, and CRT sequence were associated with OS (all P <.05). Among which, LDT and MTV were proved to be the independent prognostic factors for OS (hazard ratio [HR]: 3.437, 3.015, both P <.05). Additionally, LDT and CRT sequence were found associated with PFS (both P <.05), and CRT sequence was the independent prognostic factor for PFS in chemo-SBRT treated LAPC patients (HR: 0.130, P <.05). For LAPC patients received chemotherapy and SBRT combined therapy, MTV and LDT showed independent prognostic values for OS. Meanwhile, CRT sequence was an independent PFS prediction factor.

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Prognostic value of the maximum standardized uptake value of pre-treatment primary lesions in small-cell lung cancer on 18F-FDG PET/CT: a meta-analysis

Cited by 21 publications

References 36 publications

The role of 18F-FDG PET/CT in management of paraneoplastic limbic encephalitis combined with small cell lung cancer

The role of 18F-FDG PET/CT in management of paraneoplastic limbic encephalitis combined with small cell lung cancer

Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer

Prognostic values of 18F-FDG PET/CT metabolic parameters and clinical figures in locally advanced pancreatic cancer underwent chemotherapy combined with stereotactic body radiation therapy

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