Prognostic value of the number of negative lymph nodes in esophageal carcinoma without lymphatic metastasis

Wu, Hanran; Liu, Changqing; Xu, Meiqing; Guo, Mingzhou; Xu, Shibin

doi:10.1111/1759-7714.12796

Cited by 14 publications

(17 citation statements)

References 21 publications

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“…In the present study, a robust five-gene signature to predict the prognosis of patients with ESCC was constructed and validated. However, additional confounding factors should also be considered, including the number of negative lymph nodes (22), metabolic tumor volume, total lesion glycolysis, regional lymph node metastasis and concurrent chemotherapy (23). Furthermore, the included data were limited to two databases, thus the impact of these confounding factors could not be fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

A five‑gene signature to predict the overall survival time of patients with esophageal squamous cell carcinoma

Yan

et al. 2019

Oncol Lett

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Esophageal squamous cell carcinoma (ESCC) is one of the six most commonly diagnosed tumor types in the Chinese population. Gene expression profiles help to predict the prognosis of patients with ESCC. Disease recurrence as the survival endpoint has been analyzed in the majority of previous studies; therefore, the aim of the present study was to construct a robust gene signature in order to determine the overall survival (OS) of patients with ESCC. The gene expression and clinical data of patients with ESCC were downloaded from The Cancer Genome Atlas (TCGA) database. Of the selected data (172 samples from surviving patients), 72 samples were randomly selected as modeling data, and verification was conducted using the entire dataset. Data from the Gene Expression Omnibus was analyzed simultaneously, and a venn diagram was constructed to determine the intersection between these two sets of results; a total of 97 genes were found to be associated with OS. Kyoto Encyclopedia of Genes and Genomes analysis demonstrated that these genes were primarily associated with specific pathways (Homo sapiens), including DNA replication, protein processing in endoplasmic reticulum and influenza A. A five-gene signature was identified with a robust likelihood-based survival modeling approach. Using regression coefficient modeling, a prognostic model consisting of the C-X-C motif chemokine ligand 8, DNA damage inducible transcript 3, RAB27A, member RAS oncogene family, replication factor C subunit 2 and elongation factor for RNA polymerase II 2 genes was constructed and validated. Based on these results, patients were subdivided into high and low-risk groups. Compared with the high-risk group, the OS time of patients in the low-risk group was significantly increased. Furthermore, it was determined that the five genes were all differentially expressed in ESCC tissues compared with normal tissues, indicating the potential role of these genes in ESCC initiation and progression. In another independent cohort, this five-gene signature was further confirmed and was considered as an independent prognostic biomarker for OS prediction in patients with ESCC. In conclusion, the OS of patients with ESCC may be predicted using this five-gene signature, which may be useful in identifying patients with high-risk ESCC.

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Section: Discussionmentioning

confidence: 99%

A five‑gene signature to predict the overall survival time of patients with esophageal squamous cell carcinoma

Yan

et al. 2019

Oncol Lett

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“…Another study demonstrated that NLNs count was an advantageous prognostic indicator in lymph node-positive EC patients but not in those who were lymph node-negative [13]. Wu et al [14] draw the conclusion that the number of NLNs was an independent prognostic factor for node-negative EC through a retrospective review of 429 EC patients who underwent modern two-field lymphadenectomy. These results are controversial and need to be further investigated.…”

Section: Introductionmentioning

confidence: 99%

The number of negative lymph nodes is positively associated with survival in esophageal squamous cell carcinoma patients in China

Zhang

Guan

et al. 2020

Open Medicine

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AbstractBackgroundThere is a controversial relationship between the negative lymph nodes (NLNs) and survival in patients with esophageal squamous cell carcinoma (ESCC). This study investigates the implications of total number of NLNs on thoracic ESCC patient prognosis.Methods579 thoracic ESCC patients were categorized into four groups (0-9, 10-14, 15-19 and ≥20 NLNs). Univariate analysis was done by the log-rank tests while multivariate analysis was undertaken using Cox regression models. Survival analysis was determined employing the Kaplan-Meier method.ResultsWhen the numbers of NLNs were 9 or less, 10 to 14, 15 to 19 and 20 or more, patients of 3-year survival rates were 21.7%, 40.0%, 61.2% and 77.5%, respectively (P<0.001). In the node-negative and node-positive subgroups, 3-year survival rates were 34.9% and 14.3%, 50.9% and 19.3%, 65.6% and 51.8%, 81.4% and 68.9% respectively (P<0.001). Gender, tumor length, tumor differentiation, T and N stage as well as the total NLNs were found to be significantly linked to survival rates. Multivariate analysis showed tumor length, T stage, N stage and total NLNs were independent prognostic factors for ESCC patients.ConclusionNLNs numbers is a significant independent prognostic indicator for thoracic ESCC patients’ survival after curative esophagectomy.

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“…Esophageal cancer is ranked as one of the most common digestive system cancers worldwide and as the seventh most frequent cause of cancer‐related death for males in the United States …”

Section: Introductionmentioning

confidence: 99%

Should the clinical significance of supraclavicular and celiac lymph node metastasis in thoracic esophageal cancer be reevaluated?

et al. 2019

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Background Lower thoracic esophageal cancer (LTEC) with celiac node metastasis and upper thoracic esophageal cancer (UTEC) with supraclavicular node metastasis were previously categorized as M1a diseases. Our study aimed to investigate whether the clinical significance of supraclavicular and celiac lymph node metastasis should be reevaluated in thoracic esophageal cancer. Methods A total of 6178 patients with thoracic esophageal cancer were identified from the Surveillance, Epidemiology, and End Results (SEER) database during 2004–2015. Treatment strategies and outcomes (OS, overall survival; CSS, cancer‐specific survival) of patients with different nodal status were reviewed. The Cox proportional hazards regression model was applied to evaluate the prognostic factors. Statistical analyses were performed in all subgroups. Results Multivariate analysis identified supraclavicular node metastasis but not celiac node metastasis as an independent predictor of both OS and CSS in LTEC. However, metastasis to supraclavicular or celiac nodes was not an independent predictor of OS and CSS in UTEC. Surgery was not associated with increased OS and CSS for UTEC with celiac or supraclavicular node metastasis but was favored as a predictor of better OS and CSS for LTEC with celiac or supraclavicular node metastasis. Radiotherapy benefited OS and CSS in LTEC involving celiac or supraclavicular nodes and in UTEC involving celiac nodes, while only OS benefited from radiotherapy in UTEC involving supraclavicular nodes. Conclusions These results provide preliminary evidence that the clinical significance of supraclavicular and celiac lymph node metastasis should be reevaluated in thoracic esophageal cancer with different prognostic information according to the primary sites.

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Prognostic value of the number of negative lymph nodes in esophageal carcinoma without lymphatic metastasis

Cited by 14 publications

References 21 publications

A five‑gene signature to predict the overall survival time of patients with esophageal squamous cell carcinoma

A five‑gene signature to predict the overall survival time of patients with esophageal squamous cell carcinoma

The number of negative lymph nodes is positively associated with survival in esophageal squamous cell carcinoma patients in China

Should the clinical significance of supraclavicular and celiac lymph node metastasis in thoracic esophageal cancer be reevaluated?

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