Prognostic value of tumor-infiltrating lymphocytes in hepatocellular carcinoma

Ding, Wei; Xu, Xuezhong; Yan, Qian; Xue, Wenbo; Wang, Yibo; Du, Jin; Jin, Lei; Tan, Yulin

doi:10.1097/md.0000000000013301

Cited by 91 publications

(72 citation statements)

References 58 publications

(133 reference statements)

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“…On the contrary, high density of CD3 + TILs was related to better PFS after excluding the study which contributed to the high inner heterogeneity. The similar conclusion was also drawn by Ding et al in hepatocellular carcinoma 27 . And the mechanisms were not exactly explained in previous study, which needs to be answered in the future.…”

Section: Discussionsupporting

confidence: 89%

Prognostic value of tumor-infiltrating lymphocytes in gliomas: A Systematic Review

Song

Zhang

Liu

et al. 2020

Preprint

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Background: Glioma is the most common primary brain tumor with poor prognosis. Some studies have learned the prognostic role of tumor infiltrating lymphocytes (TILs) in gliomas. But conflict conclusions were drawn by these studies. In order to reach an agreement, we systematically performed a meta-analysis.Method: A systematic literature research was conducted on the Web of Science, EMBASE, PubMed, Cochrane Library and China National Knowledge Infrastructure. The eligible articles which met the inclusion criteria were included in our study. The clinical outcomes of included patients were defined as progression-free survival (PFS) and overall survival (OS). The basic characteristics and relevant data were extracted. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled to evaluate the prognostic role of TILs in gliomas. Newcastle Ottawa Scale (NOS) was used to assess the quality of included studies.Results: Eight articles published from 2008 to 2019 were finally included in our study. And 25 studies were conducted in these articles. We assessed the prognostic role of TILs in gliomas by subgroup analysis according to the subtypes of TILs. The pooled HRs for OS revealed that high density of CD3+ and CD4+ TILs were related to the poor prognosis of gliomas (HR for CD3+ TILs=1.266; HR for CD4+ TILs= 2.128). The pooled HR for PFS indicated that only high density of FOXP3+ TILs were related to poor prognosis (HR=2.785; 95%CI=1.848, 4.197).Conclusion: High density of CD3+ and CD4+ TILs may be a potential candidate for predicting poor OS of gliomas while high density of FOXP3+ TILs may serve as a good biomarker for predicting poor PFS of gliomas.

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Section: Discussionsupporting

confidence: 89%

Prognostic value of tumor-infiltrating lymphocytes in gliomas: A Systematic Review

Song

Zhang

Liu

et al. 2020

Preprint

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“…It has been long time recognised that increased Tlymphocyte infiltrate is associated with improved overall and progression free survival in HCC [29]. However, despite T-cell infiltration tumours ultimately progress and metastasise as a result of the 'exhaustion' of proinflammatory T-cell populations and accumulation of regulatory T-lymphocytes [30][31][32].…”

Section: T-cellsmentioning

confidence: 99%

Immune-based therapies for hepatocellular carcinoma

et al. 2020

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Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death. The immune-rich contexture of the HCC microenvironment makes this tumour an appealing target for immune-based therapies. Here, we discuss how the functional characteristics of the liver microenvironment can potentially be harnessed for the treatment of HCC. We will review the evidence supporting a therapeutic role for vaccines, cell-based therapies and immune-checkpoint inhibitors and discuss the potential for patient stratification in an attempt to overcome the series of failures that has characterised drug development in this disease area.

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“…TME comprises a mass of heterogeneous cell types, including tumor-in ltrating lymphocytes (TILs), endothelial cells, cancer stem cells, and broblasts, alongside cancer cells. Previous studies have shown that the ratio of TILs play a crucial role in the treatment and prognosis of various tumors, [28][29][30] including MIBC. [31] The TIL compartment could even service as a classi cation in triple negative breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Classification of muscle-invasive bladder cancer based on tumor stromal compartment

Wei¹,

Shi²,

Liang³

et al. 2020

Preprint

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Purpose There has been a resurgence of interest in the tumor stroma in recent years. Whether the relative abundance of various stromal cells can be used as a classification system for muscle-invasive bladder cancer (MIBC) remain elusive.Methods We applied single-cell RNA-sequence (scRNA-seq) data from two MIBCs to identify stromal cell (CD45 negative cells) clusters and the marker gene set of each cell cluster. The single sample gene set enrichment analysis method is used to estimate the relative abundance of the cell clusters in each MIBC sample from The Cancer Genome Atlas. Subsequently, k-means clustering was performed to cluster the MIBCs. Prognosis, oncogenic pathway enrichment score, epithelial-mesenchymal transition (EMT) score, gene mutation frequency, and tumor infiltrating lymphocytes (TILs) were compared among the stromal component-based types of MIBC.ResultsIn the scRNA-seq analysis, a total of nine cell clusters mainly composed of four types of cells were identified. Cell clusters 0, 1, 2, 3, 4, and 7 were considered as bladder epithelial cells, the cells in clusters 5 and 8 were mainly recognized as stem cells and fibroblasts, and the cell cluster 6 was recognized were endothelial cells. The 408 MIBC samples were classified into three types. Type 1 and 3, the “stromal-sufficient” type I and II with higher stromal cells, and Type 2, the “stromal-desert” type with lower stromal cells. The stromal-desert type had significantly better overall survival. As the tumor progresses, the stromal component of the stromal-desert type increases and change into the stromal-sufficient type. Increased stromal cells may come from EMT. The enrichment scores of multiple oncogenic pathways in stromal-sufficient types were significantly higher than those in stromal-desert type. More TILs were found in stromal-sufficient type, but their function may be inhibited by stromal cells. In addition, the three stromal types of MIBC may have specific gene mutation characteristics.Conclusions We proposed a novel stromal component-based classification system to divided into MIBC three phenotype. The three types of MIBC differ in various biological characteristics. The progress of MIBC may be summarized as the process of gradually increasing stromal components and constructing a microenvironment suitable for cancer cells.

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Prognostic value of tumor-infiltrating lymphocytes in hepatocellular carcinoma

Cited by 91 publications

References 58 publications

Prognostic value of tumor-infiltrating lymphocytes in gliomas: A Systematic Review

Prognostic value of tumor-infiltrating lymphocytes in gliomas: A Systematic Review

Immune-based therapies for hepatocellular carcinoma

Classification of muscle-invasive bladder cancer based on tumor stromal compartment

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