Prognostic values of proliferating cell nuclear antigen (PCNA) and Ki-67 for radiotherapy of oesophageal squamous cell carcinomas

Okuno, Yasuki; Nishimura, Yumiko; Kashu, Ippei; Ono, Kouji; Hiraoka, Masakatsu

doi:10.1038/sj.bjc.6990368

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Okuno et al reported that the expression of Ki-67 was significantly correlated with local control probabilities in esophageal cancers treated by radiotherapy [10].…”

Section: Introductionmentioning

confidence: 99%

Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy

et al. 2016

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DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation and is mainly repaired by the non-homologous end joining (NHEJ) repair. Immunohistochemical analysis of proteins involved in NHEJ, such as XRCC4 (X-ray repair cross-complementing protein 4), Ku86 and DNA-PKcs (DNA-dependent protein kinase, catalytic subunits), may be useful for predicting tumor radiosensitivity. We examined 92 patients with esophageal squamous cell carcinoma (ECSS) who were treated by radiotherapy between 1999 and 2008. Immunohistochemical examination of tumor tissue for Ki-67 and DSB-related proteins, including XRCC4, Ku86, and DNA-PKcs, was performed using pretreatment biopsy specimens. Low expression of XRCC4 was detected in 31 of 92 examined samples (33.7 %). The 5-year overall survival (OS) rate was 67.7 % in the low expression group and 31.0 % in the high expression group (P = 0.00). Multivariate analysis confirmed that advanced T-stage (HR 3.24, P = 0.01), radiation dose less than 66 Gy (HR 2.23, P = 0.02), absence of systemic chemotherapy (HR 2.59, P = 0.05), and high expression of XRCC4 (HR 12.0, P = 0.02) were independent prognostic factors for predicting poor OS. Other DSB-related proteins and Ki-67 were not predictive factors. XRCC4 expression might have an influence on results of radiotherapy for patients with ESCC.

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“…Okuno et al reported that the expression of Ki-67 was significantly correlated with local control probabilities in esophageal cancers treated by radiotherapy [10].…”

Section: Introductionmentioning

confidence: 99%

Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy

et al. 2016

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“…4). The indices of both primary and metastatic lesions (28% and 38%, respectively) were considered relatively low compared to the results of Okuno et al [5] showing the median value of the Ki-67 index was 43% (range, 3-78%) in 65 esophageal squamous cell carcinoma patients. This result might indicate the slow-growing nature of this cancer.…”

Section: Discussionmentioning

confidence: 99%

Long-term survival after resection of paraaortic lymph node metastasis that developed 6 years after the esophagectomy

et al. 2011

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A 62-year-old man underwent subtotal esophagectomy with an extended three-field lymph node dissection for squamous cell carcinoma of the lower thoracic esophagus (histological stage pT3N1M0, pStage III). Computed tomography showed a swollen paraaortic lymph node about 6 years later. Positron emission tomography also indicated lymph node metastasis. The patient was treated with surgery, and the lymph node was diagnosed to be metastasis of esophageal cancer. Surgery was followed by chemotherapy with nedaplatin and 5-fluorouracil. The patient has remained alive more than 5 years after surgery without any evidence of recurrence. Although the optimal treatment for the recurrence region of esophageal cancer remains controversial, the current case suggests the possibility of performing a salvage resection for a lymph node recurrence of esophageal cancer in selected patients.

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Prognostic values of proliferating cell nuclear antigen (PCNA) and Ki-67 for radiotherapy of oesophageal squamous cell carcinomas

Cited by 2 publications

References 13 publications

Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy

Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy

Long-term survival after resection of paraaortic lymph node metastasis that developed 6 years after the esophagectomy

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