In this review summary, efforts have been put to assimilate the results of research that employed the glucose based enzymatic biofuel cells in the biomedical applications. All the analysis involving studies and research have been done on mammals and fruits before it would be tried on human beings. As we know the issues associated with the pacemakers integrated with lithium batteries would provide the power to the device for few years after which the patient must undergo for the surgical replacement which would result in more bills to pay as well as the health risk due to the chances of infections. Thus, the scientists focused the research on the utilization of the ambient energy of the body to run the implanted biomedical devices for life long duration without any replacement.