Programmed Death-1 (PD-1) is a Marker of Germinal Center-associated T Cells and Angioimmunoblastic T-Cell Lymphoma

Abstract

Programmed death-1 (PD-1), a member of the CD28 costimulatory receptor family, is expressed by germinal center-associated T cells in reactive lymphoid tissue. In a study of a wide range of lymphoproliferative disorders, neoplastic T cells in 23 cases of angioimmunoblastic lymphoma were immunoreactive for PD-1, but other subtypes of T cell and B cell non-Hodgkin lymphoma, as well as classic Hodgkin lymphoma, did not express PD-1. The pattern of PD-1 immunostaining of neoplastic cells in angioimmunoblastic lymphoma was similar to that reported for CD10, a recently described marker of neoplastic T cells in angioimmunoblastic lymphoma. Tumor-associated follicular dendritic cells in cases of angioimmunoblastic lymphoma were found to express PD-L1, the PD-1 ligand. In addition, PD-1-positive reactive T cells formed rosettes around neoplastic L&H cells in 14 cases of nodular lymphocyte predominant Hodgkin lymphoma studied. These findings, along with data from previous studies, suggest that angioimmunoblastic lymphoma is a neoplasm of germinal center-associated T cells and that there is an association of germinal center-associated T cells and neoplastic cells in nodular lymphocyte predominant Hodgkin lymphoma. PD-1 is a useful new marker for angioimmunoblastic lymphoma and lends further support to a model of T-cell lymphomagenesis in which specific subtypes of T cells may undergo neoplastic transformation and result in specific, distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.

The darker side of follicular helper T cells: from autoimmunity to immunodeficiency

“…Recent studies have suggested that T FH cells and neoplastic AITL cells share the expression of many phenotypic markers, and that the AITL cells may be derived from T FH cells. [64][65][66][67][68] Examples of these markers expressed by both T FH cells and neoplastic AITL cells include Bcl6, CXCR5, PD-1, CD40L, OX40 and CXCL13. However, neoplastic AITL cells, in contrast to T FH cells, express CD10, which is a cell surface zinc metalloendopeptidase expressed in a variety of normal and neoplastic tissues.…”

Intrafollicular neoplasia/“in situ” lymphoma: A proposal for morphology and immunodiagnostic classification

“…5) [9,[21][22][23][24]. Typically, the tumor cells of AITL have a T-helper cell phenotype expressing CD3, CD4, and frequently CD10, similar to a subset of normal GC-Th cells [23,25] (Table III).…”

High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new-onset rheumatoid arthritis

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