Programmed Death-1+ T Cells and Regulatory T Cells Are Enriched in Tumor-Involved Lymph Nodes and Associated with Aggressive Features in Papillary Thyroid Cancer

French, Jena D.; Kotnis, Gregory; Said, Sherif; Raeburn, Christopher D.; McIntyre, Robert C.; Klopper, Joshua; Haugen, Bryan R.

doi:10.1210/jc.2011-3428

Cited by 118 publications

(124 citation statements)

References 36 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Lymph node metastatic tissues had lower levels of B7H1 than the primary tumor, suggesting an exhaustion of T-cell activation. French et al (2012) recently described high levels of IFNC/CD8CT cells in 12 metastatic lymph node tissues excised during the initial surgery, at patient presentation. The authors found that proliferating lymphocytes were evident in tumor-involved lymph node metastases that, in opposition to our findings, were enriched with PD-1C lymphocytes (French et al 2012).…”

Section: Discussionmentioning

confidence: 98%

“…French et al (2012) recently described high levels of IFNC/CD8CT cells in 12 metastatic lymph node tissues excised during the initial surgery, at patient presentation. The authors found that proliferating lymphocytes were evident in tumor-involved lymph node metastases that, in opposition to our findings, were enriched with PD-1C lymphocytes (French et al 2012). They hypothesized that the presence of metastases does not arrest and may, on the contrary, promote an IFNC response, suggesting the generation of an antitumor response, which may impair tumor evasion.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Differentiated thyroid carcinomas may elude the immune system by B7H1 upregulation

Cunha¹,

Marcello²,

Morari³

et al. 2012

Endocrine-Related Cancer

View full text Add to dashboard Cite

B7H1 is consistently associated with inhibition of the immune system in many solid tumors. However, there is no report about its impact on differentiated thyroid carcinoma (DTC) presentation, aggressiveness, or evolution. Aiming to investigate the role of B7H1 in DTC and correlate this protein with other tumor-infiltrating immune cells, we studied 407 thyroid nodule tissue samples including 293 from DTC patients, all managed according to a same standard protocol. In addition, we obtained 5 normal and 114 benign thyroid lesions. Eighteen out of the 253 papillary thyroid carcinomas were paired with respective metastatic lymph node tissues. B7H1 (CD274) protein expression was assessed by immunohistochemistry and the gene expression was quantified by real-time PCR. Malignant tissues displayed a more intense B7H1 staining and higher mRNA levels than benign tissues (both P!0.0001). We observed a positive linear correlation between higher age at diagnosis and B7H1 mRNA levels (PZ0.02896). Elevated levels of B7H1 protein were associated with the presence of CD4C, CD8C, CD20C, and FoxP3C lymphocytes (all P!0.05); tumor-associated macrophages (P!0.0001); and the presence of myeloid-derived suppressor cells (PZ0.03256). Stage II-IV patients presented higher B7H1 mRNA levels than stage I cases (PZ0.03522). On the contrary, a decreased expression of B7H1 protein was observed in lymph node metastasis (PZ0.0152). In conclusion, our data demonstrate that B7H1 expression is associated with features of aggressiveness, suggesting that this is an immune evasion mechanism of DTC cells.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Differentiated thyroid carcinomas may elude the immune system by B7H1 upregulation

Cunha¹,

Marcello²,

Morari³

et al. 2012

Endocrine-Related Cancer

View full text Add to dashboard Cite

show abstract

“…107 Moreover, increased PD-1 C T cells in metastatic lymph nodes correlated with a more aggressive TC. 108 In a small PTC patient dataset, Foxp3 C Tregs and VEGF, evaluated by immunohistochemistry, were found in PTC samples and Treg infiltration correlated with disease stage and lymph node metastasis. 109 A higher Treg density was also observed in PTC samples compared with nodular goiter, and positively correlated to the stage of the disease.…”

Section: Natural Killer T Cells (Nkt) Gd T Cells and Innate Lymphoidmentioning

confidence: 95%

The immune network in thyroid cancer

2016

View full text Add to dashboard Cite

The immune system plays critical roles in tumor prevention, but also in its initiation and progression. Tumors are subjected to immunosurveillance, but cancer cells generate an immunosuppressive microenvironment that favors their escape from immune-mediated elimination. During chronic inflammation, immune cells can contribute to the formation and progression of tumors by producing mitogenic, prosurvival, proangiogenic and lymphangiogenic factors. Thyroid cancer is the most frequent type of endocrine neoplasia and is the most rapidly increasing cancer in the US. In this review, we discuss recent findings on how different immune cells and mediators can contribute to thyroid cancer development and progression.

show abstract

“…Divergent reports, however, have to be mentioned. In fact, the presence in PTC and metastatic nodes of T cells, macrophages, pDCs, and T reg cells was associated to increased tumor progression, invasion, node metastasis, and an overall decreased cancer-related survival [37].…”

Section: Cellular and Humoral Immune Responsementioning

confidence: 99%

“…IL-4 reduces the proliferation and impairs the function of cytotoxic CD8+ T cells. PTCderived DCs favor the differentiation of CD4+ T cells into T reg cells [44] that are increased in more aggressive PTC and node metastasis [37]. T reg cells are able to suppress NK cell functions.…”

Section: Cellular and Humoral Immune Responsementioning

confidence: 99%

Thyroid Autoimmunity and Cancer

Felicetti¹,

Catalano²,

Fortunati³

2017

Frontiers of Hormone Research

View full text Add to dashboard Cite

Cancer and autoimmune diseases are often associated in the same individual. The functional link between immune system and cancer development is only partially known. Even though the immune system can control the development of cancer through immune surveillance, cancer cell itself can escape immune surveillance. Actually, it is debated whether autoimmune diseases have to be regarded as cancer cause or its consequence.In particular, autoimmune thyroiditis and thyroid cancer (in particular, papillary thyroid cancer) are a fascinating model of this complex relationship. In the present review, we describe what has been reported by now in literature about autoimmune thyroiditis and papillary thyroid cancer, and on the basis of available data, we try to clarify the present knowledge.

show abstract

Programmed Death-1+ T Cells and Regulatory T Cells Are Enriched in Tumor-Involved Lymph Nodes and Associated with Aggressive Features in Papillary Thyroid Cancer

Abstract: Increased Treg and PD-1(+) T cell frequencies in LN may be indicative of aggressive recurrent PTC. Future prospective studies are necessary to determine the prognostic and therapeutic value of these findings in PTC.

Cited by 118 publications

References 36 publications

Differentiated thyroid carcinomas may elude the immune system by B7H1 upregulation

Differentiated thyroid carcinomas may elude the immune system by B7H1 upregulation

The immune network in thyroid cancer

Thyroid Autoimmunity and Cancer

Contact Info

Product

Resources

About