Progress and opportunities through use of genomics in animal production

Jones, Huw E.; Wilson, Philippe B.

doi:10.1016/j.tig.2022.06.014

Cited by 12 publications

(7 citation statements)

References 214 publications

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“…These alterations have an impact on an organism’s phenotype [ 48 ]. The most common form of mutation in the mammalian genome is known as an SNP, which is a DNA sequence polymorphism that occurs at significant levels in a population [ 9 , 20 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphism of myostatin gene in Sumba Ongole (Bos indicus) cattle and its association with growth traits

Gaina¹,

Amalo²

2022

J Adv Vet Anim Res

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Objective: As one of the most valuable genetic resources of Ongole beef cattle globally, the Sumba Ongole (SO) cattle population is being studied in this investigation of myostatin (MSTN) gene polymorphism and its association with growth traits. Materials and Methods: Blood samples from 161 SO cattle were collected and analyzed. Deoxyribonucleic acid (DNA) was isolated. The DNA was electrophoresed and extracted, and finally, the annealing temperature was optimized, followed by amplification and sequencing. Next, we used a Basic local alignment search tool to assess the sequencing data. Results: The analysis revealed 22 single nucleotide polymorphisms (SNPs) in the MSTN gene in this region that showed genetic variation. Two SNPs, c.424 G > A, and c.467 G > C, were found to be significantly associated with SO cattle phenotypes of wither height, heart girth, and hip height (p < 0.05) but not with body weight or body length (p > 0.05). Conclusion: As a result of our findings, the MSTN gene polymorphism and its correlation with growth traits in SO cattle may be employed as a candidate marker in SO cattle and other beef cattle breeds.

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Section: Discussionmentioning

confidence: 99%

Genetic polymorphism of myostatin gene in Sumba Ongole (Bos indicus) cattle and its association with growth traits

Gaina¹,

Amalo²

2022

J Adv Vet Anim Res

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“…Recent strides in MAS have focused on integrating genomic data with advanced statistical models, providing breeders with improved insights into and predictions of the heritability of reproductive traits. This integrated approach has significantly boosted the effectiveness of breeding programs, leading to a swifter and more targeted genetic improvement in livestock species [116]. Furthermore, MAS has expanded its application beyond traditional livestock species to include aquaculture and other animal breeding sectors, contributing to advancements in reproductive traits and productivity [115].…”

Section: The Evolution Of Marker-assisted Selection In Reproduction-r...mentioning

confidence: 99%

Overview of Marker-assisted Selection in Animal Breeding

Sharma,

Doultani,

Hadiya

et al. 2024

JABB

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Marker-assisted selection (MAS) in animal breeding has undergone transformative advancements, reshaping genetic improvement and reproductive traits in livestock and expanding into new domains. From its inception in the late 20th century to current developments, MAS has evolved dynamically through the integration of genomic technologies, sophisticated statistical models, and innovative gene editing techniques. These advancements have significantly enhanced the precision and impact of MAS, revolutionizing genetic improvement and reproductive performance. By synergizing MAS with cutting-edge technologies, the collective aim is to optimize reproductive performance and genetic potential, fostering a sustainable and productive future for livestock breeding and beyond. The genetic markers, typically DNA sequences or genes linked to specific traits, revolutionized animal breeding by enabling the identification of animals carrying favorable genetic variants without the need for resource-intensive phenotypic evaluations. Marker-assisted selection in reproduction also laid the foundation for genomic selection, an advanced approach utilizing genome-wide markers to estimate breeding values and predict genetic potential. This comprehensive review encapsulates the journey of MAS, emphasizing its historical significance, current advancements, and promising future trajectories, showcasing its pivotal role in shaping the landscape of animal breeding and reproductive science.

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“…With the aim of sustaining the integration of genomics insights and capacities into multisectoral policies, a strong emphasis should be placed on creating meaningful alliances and capacity building, and more specifically, around promising young and future genomicists. The broad “genomic revolution” already had a favourable impact on numerous fields around the world, including veterinary sciences, industrial biotechnology, agricultural biosciences, and environmental research (Bernatchez et al, 2017; Jones & Wilson, 2022; McCormick & Calzone, 2016). Transitions from basic genomics information to a wide range of application needs for Africa are also being tested (Marshall et al, 2017; Wolfe et al, 2017).…”

Section: Synthesis: Genomics For Sustainable Africamentioning

confidence: 99%

“…The broad "genomic revolution" already had a favourable impact on numerous fields around the world, including veterinary sciences, industrial biotechnology, agricultural biosciences, and environmental research (Bernatchez et al, 2017;Jones & Wilson, 2022;McCormick & Calzone, 2016). Transitions from basic genomics information to a wide range of application needs for Africa are also being tested F I G U R E 4 Pathway to impact framework in ecological and adaptive genomics for Africa.…”

Section: Synthe S Is: G Enomic S For Sus Tainab Le Afric Amentioning

confidence: 99%

Vertebrate genomics and adaptation – Status and prospects in Africa

Ishengoma

2023

Molecular Ecology

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Africa is considered the "mother continent" from which the first hominins arose.The diversified wildlife and flora of Africa, which ranges from those in the scorching Sahara and Kalahari deserts to those in the vast Savannas and wet tropical forests, are also the most diverse of any continent. Although the continent's abundance and diversity of living resources have provided critical means of subsistence for its inhabitants, future utilization of this biodiversity will demand a fundamental understanding of genetic variation and its adaptive capabilities in the face of natural and man-made stressors. Molecular ecological insights have previously been gained from a variety of vertebrate species native to Africa, and some of these discoveries have larger evolutionary and conservation implications. Despite lagging in genomics research, African scientists are increasingly eager to use the increasingly accessible -omics technology to routinely sequence more animals and plants native to Africa. This overview, which focuses on Africa's vertebrate biodiversity, aims to provide a continental scale perspective on organismal and ecological adaptations discovered through prior genomics research, as well as what conceptually these findings suggest for future research.

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Progress and opportunities through use of genomics in animal production

Cited by 12 publications

References 214 publications

Genetic polymorphism of myostatin gene in Sumba Ongole (Bos indicus) cattle and its association with growth traits

Genetic polymorphism of myostatin gene in Sumba Ongole (Bos indicus) cattle and its association with growth traits

Overview of Marker-assisted Selection in Animal Breeding

Vertebrate genomics and adaptation – Status and prospects in Africa

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