Progress and perspective of biosynthetic platform for higher-order biofuels

Su, Haifeng; Lin, Jiafu; Tan, Furong

doi:10.1016/j.rser.2017.05.158

Cited by 12 publications

(6 citation statements)

References 255 publications

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“…Single-strains or engineered cultures have their place when the product is of high enough value and require a certain purity. Overall, the production of MCCAs, and other medium chain chemicals, using pure, engineered cultures has been recently reviewed by other authors, e.g., Sarria et al [67] and Su et al [68].…”

Section: Chain Elongation Behaviour Of Pure Cultures Can Be Extendmentioning

confidence: 99%

Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation

et al. 2019

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Environmental pressures caused by population growth and consumerism require the development of resource recovery from waste, hence a circular economy approach. The production of chemicals and fuels from organic waste using mixed microbial cultures (MMC) has become promising. MMC use the synergy of bio-catalytic activities from different microorganisms to transform complex organic feedstock, such as by-products from food production and food waste. In the absence of oxygen, the feedstock can be converted into biogas through the established anaerobic digestion (AD) approach. The potential of MMC has shifted to production of intermediate AD compounds as precursors for renewable chemicals. A particular set of anaerobic pathways in MMC fermentation, known as chain elongation, can occur under specific conditions producing medium chain carboxylic acids (MCCAs) with higher value than biogas and broader applicability. This review introduces the chain elongation pathway and other bio-reactions occurring during MMC fermentation. We present an overview of the complex feedstocks used, and pinpoint the main operational parameters for MCCAs production such as temperature, pH, loading rates, inoculum, head space composition, and reactor design. The review evaluates the key findings of MCCA production using MMC, and concludes by identifying critical research targets to drive forward this promising technology as a valorisation method for complex organic waste.

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Section: Chain Elongation Behaviour Of Pure Cultures Can Be Extendmentioning

confidence: 99%

Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation

et al. 2019

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“…Intensive investigations are currently oriented toward the exploration of renewable energy sources as substitutes to fossil fuels [1, 2]. Among such sources, oleaginous microorganisms that can accumulate more than 20% lipids dry weight represent promising substitutes [3].…”

Section: Introductionmentioning

confidence: 99%

Species disparity response to mutagenesis of marine yeasts for the potential production of biodiesel

Bessadok

Santulli²,

Brück

et al. 2019

Biotechnol Biofuels

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Background: Among the third-generation biodiesel feed stock, oleaginous marine yeasts are the least studied microorganisms for such purpose.Results: Wild strains yeasts were isolated from various Tunisian marine sources including fish waste (Candida tenuis CtTun15, Debaryomyces hansenii DhTun2015, Trichosporon asahii TaTun15 and Yarrowia lipolytica YlTun15) and seawater (Rhodotorula mucilaginosa RmTun15). Following incubation with ethyl methanesulfonate (EMS: 75 mM) for various periods of time (T15, T30, T45, T60 min), the cell viability of these strains responded differentially according to yeast species. For instance, mutated CtTun15 did not survive after 30 min of EMS treatment; higher resistances were observed in DhTun2015 (45 min), in YlTun15, RmTun15 and in TaTun15 (60 min) but with significant decreased cell viabilities (survival rate: 6.02, 3. 16, 11.22, 11.58, 7.70%, respectively). For all surviving mutated strains, the optima of biomass and lipid yields were detected after 96 h in YPD culture; but derived from strains submitted to different period of EMS incubation. In most mutated strains, the maximum biomass (BP) and lipid (LP) productivities coincided and were observed after 30 min of EMS incubation. Only CtTun15 showed different optima of BP and LP (after 30 min and 15 min, respectively). The fatty acids (FA) compositions considered essential in the prediction of biodiesel criteria; were highly affected by EMS mutagenesis. Essentially, 30-and 45-min EMS incubation induced the highest levels of PUFA and MUFA in YlTun15, RmTun15 and TaTun15 with non-significant differences in the different times. However, CtTun15 and DhTun2015 mutant strains responded differently, with the highest levels of MUFA observed following 15 and 45 min; and that of PUFA after 30 and 45 min, respectively. Conclusion:The methyl-esterification of FA from the three mutated yeast strains (30 min-YlTun15, RmTun15 and TaTun15) yielded biodiesel with physical proprieties consistent with the International Standard System. However, investigations are needed for up-scaling biodiesel production.

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“…Synthetic biology tools such as genome editing technology, multi-gene simultaneous regulation technology, protein skeleton technology, and high-throughput screening technology are commonly reported as microbial cell factory technologies (Liu et al 2021a ; Jung et al 2021 ; Su et al 2017 ).…”

Section: Synthetic Biology Tools For Constructing and Optimizing Micr...mentioning

confidence: 99%

Synthetic biology promotes the capture of CO2 to produce fatty acid derivatives in microbial cell factories

Liu

Luo

et al. 2022

Bioresour. Bioprocess.

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Environmental problems such as greenhouse effect, the consumption of fossil energy, and the increase of human demand for energy are becoming more and more serious, which force researcher to turn their attention to the reduction of CO2 and the development of renewable energy. Unsafety, easy to lead to secondary environmental pollution, cost inefficiency, and other problems limit the development of conventional CO2 capture technology. In recent years, many microorganisms have attracted much attention to capture CO2 and synthesize valuable products directly. Fatty acid derivatives (e.g., fatty acid esters, fatty alcohols, and aliphatic hydrocarbons), which can be used as a kind of environmentally friendly and renewable biofuels, are sustainable substitutes for fossil energy. In this review, conventional CO2 capture techniques pathways, microbial CO2 concentration mechanisms and fixation pathways were introduced. Then, the metabolic pathway and progress of direct production of fatty acid derivatives from CO2 in microbial cell factories were discussed. The synthetic biology means used to design engineering microorganisms and optimize their metabolic pathways were depicted, with final discussion on the potential of optoelectronic–microbial integrated capture and production systems.

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Progress and perspective of biosynthetic platform for higher-order biofuels

Cited by 12 publications

References 255 publications

Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation

Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation

Species disparity response to mutagenesis of marine yeasts for the potential production of biodiesel

Synthetic biology promotes the capture of CO2 to produce fatty acid derivatives in microbial cell factories

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