Progress and perspective on hydrogen sulfide donors and their biomedical applications

Abstract

Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H 2 S) has been identified

Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide

“…Allicin decomposes into its oil-soluble derivatives: diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) [ 8 , 33 ]. Allyl sulfides are responsible for the pungency of garlic, they show greater stability than allicin under normal conditions (room temperature, oxygen, and humidity), and are able to liberate H 2 S under physiological circumstances [ 10 , 11 ].…”

“…Natural OSCs include the pharmacologically active constituents of garlic ( Allium sativum ), such as the highly reactive allicin and its allyl sulfide derivatives. Allyl sulfides are remarkably more stable than allicin and are able to release H 2 S under physiological conditions [ 10 , 11 ]. Moreover, garlic-derived OSCs show structural similarities with allyl isothiocyanate (AITC, found in mustard oil) and they are able to excite an AITC-sensitive subpopulation of peptidergic primary sensory neurons via the activation of the Transient Receptor Potential Ankyrin 1 (TRPA1) receptor [ 12 ].…”

Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter

“…In addition to endogenous H 2 S, exogenous sources from the consumption of natural H 2 S-producing compounds, such as those present in vegetables, or the administration of synthetic H 2 S donors can achieve similar physiological effects [ 7 ]. Currently, studies are ongoing toward the development of H 2 S donors as therapeutic drugs for various diseases [ 8 , 9 , 10 , 11 ]. Among them, sulfide salts (Na 2 S and NaHS) are considered fast H 2 S donors.…”

“…Based on disease scenarios, different delivery approaches can be utilized to apply H 2 S donors-of-choice to patients to reach optimal results. The readers may refer to a few recent reviews on the different types of H 2 S donors and their potential clinical applications [ 8 , 9 , 10 , 11 , 15 ]. To write this review, we performed a literature search on recent publications related to H 2 S donors and the molecular and cellular responses after the treatment of H 2 S donors in in vitro and in vivo disease models.…”

Controllable Cycloadditions between 2H-(Thio)pyran-2-(thi)ones and Strained Alkynes: A Click-and-Release Strategy for COS/H2S Generation

“…In the past decade, research on novel H 2 S-releasing compounds (also known as H 2 S donors) has received considerable attention, and many different H 2 S donors have been developed (some examples are shown in Scheme 1a). 5,6 The release of H 2 S from those compounds is controlled by cellular factors (such as pH, biothiols, enzymes, etc.) or biologically compatible triggers (e.g., light).…”