Progress in Applicability of Scoring Systems Based on Nutritional and Inflammatory Parameters for Ovarian Cancer

Abstract

Ovarian cancer is a malignancy that seriously endangers women’s health; its case fatality rate ranks first among the gynecological malignancies. The status of nutrition of ovarian cancer patients is related to their prognoses. Thus, it is important to evaluate, monitor, and improve the nutritional status of ovarian cancer patients during their treatment. Currently, there are several tools for examining malnutrition and nutritional assessment, including NRI (nutrition risk index), PG-SGA (patient-generated subjective global assessment), and NRS 2002 (nutritional risk screening 2002). In addition to malnutrition risk examination and related assessment tools, the evaluation of muscle mass, C-reactive protein, lymphocytes, and other inflammation status indicators, such as neutrophils to lymphocytes ratio, lymphocyte-to-monocyte ratio, and C-reactive protein-albumin ratio, is of great importance. The nutritional status of ovarian cancer patients undergoing surgery affects their postoperative complications and survival rates. Accurate evaluation of perioperative nutrition in ovarian cancer patients is crucial in clinical settings. An intelligent nutritional diagnosis can be developed based on the results of its systematic and comprehensive assessment, which would lay a foundation for the implementation of personalized and precise nutritional therapy.

Association between nutritional status assessed by a digital self-administered tool (R+ dietitian) and clinicopathologic factors in cancer patients: A comprehensive analysis

“… 26 Additionally, other studies have indicated that NRS-2002 and PG-SGA-SF scores are inversely correlated with various nutritional parameters in cancer patients. 30 – 32 The findings of this study are consistent, as both nutritional risks scoring systems were negatively correlated with total protein, prealbumin, body weight, BMI, energy intake, protein intake, and other variables. And PG-SGA-SF scores predicted the long hospital stays.…”

Pre-Operative Malnutrition in Patients with Ovarian Cancer: What Are the Clinical Implications? Results of a Prospective Study

“…The nutritional parameters used in our study were cost-effective, non-invasive, and simple to use. Other nutritional parameters such as the patient-generated subjective global assessment (PG-SGA) and the subjective global assessment (SGA) have been used in studies, to classify between 0 and 81.4% of EOC patients as malnourished [14][15][16][17][18][19]31]. Moreover, we did not use SGA and PG-SGA in our study.…”

“…It is unclear why platinum-resistant patients are at higher risk of malnutrition than platinum-sensitive patients. Perhaps the platinum-resistant tumor biology, due to its worse prognosis and more aggressive natural course, causes metabolic changes leading to malnutrition [31,33,34] (Eisenkop, 2001 #32).…”

Controlling Nutritional Status (CONUT) score as a prognostic marker for gastrointestinal stromal tumors

“…CONUT score, as a more straightforward and more objective nutritional evaluation index, was calculated by three common factors, including serum ALB, TLC, and total cholesterol concentration. Low ALB level can be frequently found in tumor progression and is considered relevant to general nutritional status and systemic in ammation (21,22). Lymphocytes, the primary cells of human immunity, play key roles in host immune response and anti-tumor formation (23).…”