Progress in electrochemiluminescence biosensors based on organic framework emitters

Zhan, Ziying; Ding, Zhifeng

doi:10.1016/j.coelec.2023.101283

Cited by 18 publications

(7 citation statements)

References 54 publications

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“…( 6) New types of methods for reticular nanoemitter construction should be discovered, which may simplify synthesis. (7) The conductivity of framework-based emitters should be improved by integrating the redox-active ligands in the frameworks [128]. In a word, the key of ECL techniques relies heavily on the improvement of emitters, suggesting that ECL-active frameworks with a good stability, easy accessibility, and high ECL efficiency are urgently required in future research.…”

Section: Discussionmentioning

confidence: 99%

Framework-Enhanced Electrochemiluminescence in Biosensing

Hou

et al. 2023

Chemosensors

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Electrochemiluminescence (ECL) has attracted increasing attention owing to its intrinsic advantages of high sensitivity, good stability, and low background. Considering the fact that framework nanocrystals such as metal–organic frameworks and covalent organic frameworks have accurate molecular structures, a series of framework-based ECL platforms are developed for decoding emission fundamentals. The integration of fluorescent ligands into frameworks significantly improves the ECL properties due to the arrangement of molecules and intramolecular electron transfer. Moreover, the various framework topologies can be easily functionalized with the recognition elements to trace the targets for signal readout. These ECL enhancement strategies lead to a series of sensitive analytical methods for protein biomarkers, DNA, small biomolecules, and cells. In this review, we summarize recent advances in various functions of frameworks during the ECL process, and constructions of framework-based ECL platforms for biosensing. The framework-based ECL nanoemitters and enhancement mechanisms show both theoretical innovation and potential applications in designing ECL biosensing systems. Perspectives are also discussed, which may give a guideline for researchers in the fields of ECL biosensing and reticular materials.

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Section: Discussionmentioning

confidence: 99%

Framework-Enhanced Electrochemiluminescence in Biosensing

Hou

et al. 2023

Chemosensors

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“…Electrochemiluminescence (ECL) represents a special luminescent phenomenon generated in the vicinity of a working electrode by electrochemical excitation. 1–4 Owing to the intrinsic advantages of high specificity, excellent sensitivity, easy controllability, and low background, ECL exhibits unique superiority over other spectroscopy-based detection systems. 5,6 In general, luminophores play a vital role in developing ultrasensitive ECL systems.…”

Section: Introductionmentioning

confidence: 99%

Artemisinin: a novel chiral electrochemiluminescence luminophore-assisted enantiospecific recognition and mechanism identification

Wang,

Han,

Shang

et al. 2024

Chem. Sci.

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“…The electrochemiluminescence (ECL) sensing system, known for its high sensitivity, simplified instrumentation, and excellent controllability, has been widely applied to environmental pollutant monitoring, pharmaceutical analysis, and clinical detection. , To provide increased promotion for the evolution of ECL sensing applications, the exploitation of high-performing ECL emitters and co-reaction accelerators plays a crucial role . Various ECL emitters are being continuously developed, including the classic inorganic complex (e.g., ruthenium), organic molecules (e.g., luminol and porphyrins), , metal nanoclusters (e.g., gold and copper nanoclusters), quantum dots (e.g., carbon dots), etc.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles In Situ Enhanced Electrochemiluminescence of the Porphyrin Organic Matrix for Highly Sensitive and Rapid Monitoring of Tetracycline Residues

Han,

Shi,

Kang

et al. 2024

J. Agric. Food Chem.

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Accurate monitoring of tetracycline (TC) residues in the environment is crucial for avoiding contaminant risk. Herein, a novel TC biosensor was facilely designed by integrating silver nanoparticles (Ag NPs) into the porphyrin metal−organic matrix (Ag@AgPOM) as a bifunctional electrochemiluminescence (ECL) probe. Different from the step-by-step synthesis of the coreaction accelerator and ECL emitter, the co-reaction accelerators Ag NPs were in situ-grown on the surface of 5,10,15,20-tetrakis (4-carboxyphenyl) porphyrin (TCPP) via a simple one-pot approach. Symbiotic Ag NPs on Ag@AgPOM formed an intimate interface and increased the collision efficiency of the ECL reaction, achieving the ECL enhancement of TCPP. Under the optimized conditions, the ternary ECL biosensor showed a wide linear detection range toward TC with a low detection limit of 0.14 fmol L −1 . Compared with the traditional HPLC and ELISA methods, satisfied analytical adaptability made this sensing strategy feasible to monitor TC in complex environmental samples.

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Progress in electrochemiluminescence biosensors based on organic framework emitters

Cited by 18 publications

References 54 publications

Framework-Enhanced Electrochemiluminescence in Biosensing

Framework-Enhanced Electrochemiluminescence in Biosensing

Artemisinin: a novel chiral electrochemiluminescence luminophore-assisted enantiospecific recognition and mechanism identification

Silver Nanoparticles In Situ Enhanced Electrochemiluminescence of the Porphyrin Organic Matrix for Highly Sensitive and Rapid Monitoring of Tetracycline Residues

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