Progress in Experimental Porcine Small-Bowel Transplantation

Kaneko, Hironori; Hancock, Wayne W.; Schweizer, Robert T.

doi:10.1001/archsurg.1989.01410050077016

Cited by 14 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the bowel rapidly adapts such that the diarrhea has largely resolved by 6-8 weeks postoperatively, and the body weight returns toward normal [9], Rats with isografts (or allografts with appropriate immune suppression) quickly return to a relatively normal state with full weight gain and ostensibly normal gastrointestinal function and nutri tion [10]. Similar observations have been made in the pig model [11], These latter observations are crucial because they support the basic concept that intestinal transplanta tion appears to be a viable procedure from a nutritional standpoint in its ability to maintain health and nutrition enterally -provided the problems of immunosuppression and associated superinfection can be solved.…”

Section: Global Absorptive Functionmentioning

confidence: 85%

Enteric Physiology of the Transplanted Gut: Absorption and Motility

Sarr¹

1996

Dig Surg

View full text Add to dashboard Cite

Tremendous progress has been made recently in small bowel transplantation. However, our understanding of the enteric function of the transplanted gut remains in its infancy. Unlike many of the other organs commonly transplanted, the function of the transplanted gut appears to be markedly affected by the consequences of the transplantation procedure (denervation, lymphatic disruption, and immune phenomena). This review discusses the effects of gut transplantation on segmental enteric function, concentrating on absorption and motility. Once many of the problems related to the current means of immunosuppression have been better solved, gut transplantation may prove to be an important addition for gastrointestinal surgeons to the care of patients with intestinal insufficiency.

show abstract

Section: Global Absorptive Functionmentioning

confidence: 85%

Enteric Physiology of the Transplanted Gut: Absorption and Motility

Sarr¹

1996

Dig Surg

View full text Add to dashboard Cite

show abstract

“…In contrast to some of the aforementioned studies, in demonstrated that intravenous CSA at 8 mg/kg for 5-10 days, followed by oral CSA at 25 mg/kg/day, resulted which long-term survival [16,17] was achieved with doses toxic to humans and with clinically unacceptable in graft survival of more than 100 days. Plasma CSA levels were §250 ng/ml.…”

Section: Resultsmentioning

confidence: 77%

“…Likewise, Ka-rejection was seen as early as Day 1. In contrast to the immunosuppressed group, all pigs in the nonimmunoneko et al [17] showed, in an orthotopic small bowel transplant model in pigs, that intravenous CSA (at lev-suppressed group with moderate interstitial rejection eventually died from rejection; reversal to mild rejecels ú400 ng/ml) is the most important factor in preventing rejection-despite the concomitant use of aza-tion was not noted.…”

Section: Resultsmentioning

confidence: 98%

Quadruple Immunosuppression in a Pig Model of Small Bowel Transplantation

Gruessner

Fasola

Fryer

et al. 1996

Journal of Surgical Research

View full text Add to dashboard Cite

“…The prolongation of graft survival with long-term survivors has, however, been demonstrated [17][18][19][20][21].…”

Section: Chronic Small Bowel Rejection 517mentioning

confidence: 99%

How to Diagnose Chronic Rejection. A Study in Porcine Intestinal Allografts

et al. 1997

View full text Add to dashboard Cite

Kuusanmäki P, Lauronen J, Paavonen T, Pakarinen M, Yilmaz S, Häyry P, Halttunen J. How to Diagnose Chronic Rejection. A Study in Porcine Intestinal Allografts. Scand J Immunol 1997;46:514-519 Porcine small bowel allografts were followed for 18 weeks during immunosuppression with cyclosporine-A (CyA), azatioprine and prednisone. The mucosal alterations noted at the 12th week were epithelial vacuolation and loss of Goblet cells. Moderate infiltration of inflammatory cells, mainly lymphocytes, was found in the lamina propria. In addition, a few grafts exhibited oedema and fibrosis. Vessels already showed endothelial swelling and intimal proliferation at the 12th week. In the submucosa, the infiltration of inflammatory cells was not present till the 18th week. Further changes in the mucosa at the 18th week were the blunting of villi, cuboidal epithelium, crypt abscesses and epithelial atrophy. The histological alterations of mucosa and lamina propria existing in the full thickness biopsies were mostly also detectable in mucosal biopsies, provided that multiple biopsies were taken. Thus these parameters analyzed from mucosal biopsy material are suitable for the diagnosis and monitoring of chronic small bowel rejection. In autopsy, the most prominent features were in the mesenterial arteries: intimal proliferation, vasculitis, proliferation of media and endothelial alterations. The activity of the mucosal disaccharidases maltase and sucrase remained near the initial level till the 12th week and had decreased markedly by the 18th week.

show abstract

Progress in Experimental Porcine Small-Bowel Transplantation

Cited by 14 publications

References 13 publications

Enteric Physiology of the Transplanted Gut: Absorption and Motility

Enteric Physiology of the Transplanted Gut: Absorption and Motility

Quadruple Immunosuppression in a Pig Model of Small Bowel Transplantation

How to Diagnose Chronic Rejection. A Study in Porcine Intestinal Allografts

Contact Info

Product

Resources

About