Progress in farm animal proteomics: The contribution of combinatorial peptide ligand libraries

Boschetti, Egisto; Hernández-Castellano, Lorenzo E.; Righetti, Pier Giorgio

doi:10.1016/j.jprot.2019.02.005

Cited by 15 publications

(10 citation statements)

References 190 publications

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“…Different biomarkers may be more applicable in non-bovine species, for instance, cathelicidin has been proposed for use in goats (Tedde et al, 2019). The area has been recently reviewed by Almeida and Eckersall (2018) and Boschetti et al (2019).…”

Section: Biomarkers Of Production-related Diseasesmentioning

confidence: 99%

Biomarkers of fitness and welfare in dairy cattle: healthy productivity

Zachut

Šperanda

Almeida

et al. 2020

Journal of Dairy Research

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Milk production intensification has led to several unwanted aspects, such as sustainability issues and environmental pollution. Among these, increased milk outputs that have been achieved over the last 70 years have led to several health and pathophysiological conditions in high yielding dairy animals, including metabolic diseases that were uncommon in the past. Increased occurrence of diverse metabolic diseases in cattle and other domestic animals is a key feature of domestication that not only affects the animals' health and productivity, but also may have important and adverse health impacts on human consumers through the elevated use of drugs and antibiotics. These aspects will influence economical and ethical aspects in the near future. Therefore, finding and establishing proper biomarkers for early detection of metabolic diseases is of great interest. In the present review, recent work on the discovery of fitness, stress and welfare biomarkers in dairy cows is presented, focusing in particular on possible biomarkers of energy balance and oxidative stress in plasma and milk, and biomarkers of production-related diseases and decreased fertility.

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Section: Biomarkers Of Production-related Diseasesmentioning

confidence: 99%

Biomarkers of fitness and welfare in dairy cattle: healthy productivity

Zachut

Šperanda

Almeida

et al. 2020

Journal of Dairy Research

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“…The application of omics technologies in dairy science and their association with the establishment of biomarkers is of particular interest from commercial and welfare perspectives. However, omics-based research requires specific analytical instrumentation, specialized reagents and technical knowledge which is uncommon for researchers that traditionally work in this area (Almeida et al ., 2015; Boschetti et al ., 2019). These facts may explain the difficulties of omics-based studies in farm animals compared to human medicine and preclinical animal models (e.g.…”

Section: Emergence Of New Analytical Technologies To Improve Dairy Prmentioning

confidence: 99%

Biomarkers of fitness and welfare in dairy animals: healthy living

Almeida

Zachut

Hernández-Castellano

et al. 2019

Journal of Dairy Research

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Increased animal productivity has reduced animal fitness, resulting in increased susceptibility to infectious and metabolic diseases, locomotion problems and subfertility. Future animal breeding strategies should focus on balancing high production levels with health status monitoring and improved welfare. Additionally, understanding how animals interact with their internal and external environment is essential for improving health, fitness, and welfare. In this context, the continuous validation of existing biomarkers and the discovery and field implementation of new biomarkers will enable us to understand the specific physiological process and regulatory mechanisms used by the organism to adapt to different environmental conditions. Thus, biomarkers may be used to monitor welfare and improve management and breeding strategies. In this article, we describe major achievements in the establishment of biomarkers in dairy cows and small ruminants. This review mainly focuses on the physiological biomarkers used to monitor animal responses to, and recovery from, environmental perturbations. We highlight future avenues for research in this field and present a timely positioning document to the scientific community.

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“…Proteomics is a powerful tool for improving genetic selection, and has been applied in exploring the biological mechanisms of different tissues in response to heat stress 12 – 14 . These studies provide actual biomarkers for the evaluation of health status and stress tolerance in farm animals 15 . Epigenetics, highly dynamic throughout a lifetime, can affect phenotypes by altering gene expression in response to external or internal factors without altering DNA sequences 16 , 17 .…”

Section: Introductionmentioning

confidence: 99%

Effects of acute heat stress on protein expression and histone modification in the adrenal gland of male layer-type country chickens

Zheng

Zhuang

Chen

et al. 2021

Sci Rep

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The adrenal gland responds to heat stress by epinephrine and glucocorticoid release to alleviate the adverse effects. This study investigated the effect of acute heat stress on the protein profile and histone modification in the adrenal gland of layer-type country chickens. A total of 192 roosters were subject to acute heat stress and thereafter classified into a resistant or susceptible group according to body temperature change. The iTRAQ analysis identified 80 differentially expressed proteins, in which the resistant group had a higher level of somatostatin and hydroxy-δ-5-steroid dehydrogenase but a lower parathymosin expression in accordance with the change of serum glucocorticoid levels. Histone modification analysis identified 115 histone markers. The susceptible group had a higher level of tri-methylation of histone H3 lysine 27 (H3K27me3) and showed a positive crosstalk with K36me and K37me in the H3 tails. The differential changes of body temperature projected in physiological regulation at the hypothalamus–pituitary–adrenal axis suggest the genetic heterogeneity in basic metabolic rate and efficiency for heat dissipation to acclimate to thermal stress and maintain body temperature homeostasis. The alteration of adrenal H3K27me3 level was associated with the endocrine function of adrenal gland and may contribute to the thermotolerance of chickens.

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Progress in farm animal proteomics: The contribution of combinatorial peptide ligand libraries

Cited by 15 publications

References 190 publications

Biomarkers of fitness and welfare in dairy cattle: healthy productivity

Biomarkers of fitness and welfare in dairy cattle: healthy productivity

Biomarkers of fitness and welfare in dairy animals: healthy living

Effects of acute heat stress on protein expression and histone modification in the adrenal gland of male layer-type country chickens

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