Progress in research on the anti-tumor effect of artesunate

He, Ronghai; Zhou, Huaijun

doi:10.1007/s11655-008-0312-0

Cited by 18 publications

(12 citation statements)

References 12 publications

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“…Our data also showed that microvessel density in the bone marrow from 70 patients with MM, a relative large sample size, was significantly higher than that of the control group, confirmed Sezer's conclusions [2]. Some published data showed that ART inhibited in vitro angiogenesis induced by leukemia K562 cells [21] and inhibited blood vessel development in vivo induced by Kaposi's sarcoma, malignant ovarian cancer of mouse models [19,22].…”

Section: Discussionsupporting

confidence: 84%

“…ART is a semi-synthetic artemisinin derivative and is more effective than artemisinin. In the past decade, the antitumor activity of ART has been the center of interest as a candidate drug for cancer treatment [19][20][21][22]. Several studies confirmed that ART induced damage of cancer cell DNA, arrested cell cycle, inhibited the proliferation of solid tumor cells and reversed the suppressed immune function related to tumor cells [17].…”

Section: Discussionmentioning

confidence: 99%

“…Artesunate (ART) is a water-soluble derivative of artemisinin more potent in treating malaria than artemisinin [17,18]. In addition to antimalarial effect, artemisinin and its derivatives have strong anti-tumor activity and now is the center of interest as a candidate drug for MM treatment [19][20][21][22]. Our previous studies revealed ART could effectively inhibit the proliferation of mouse myeloma SP2/0 cells and induce apoptosis of the cells [23].…”

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confidence: 99%

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Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells

et al. 2010

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Multiple myeloma (MM) remains an incurable plasma cell disorder to date; therefore, new biologically target-based therapies are in urgent demand. Our previous studies showed that the antimalarial artesunate (ART) possessed anti-myeloma effect by inhibiting proliferation and inducing apoptosis of myeloma cells. The present study evaluated the effect of ART on human myeloma cell-induced angiogenesis and elucidated its mechanism. The human umbilical vein endothelial cells (HUVECs) migration test, aortic sprouting in fibrin gel in vitro and chicken chorioallantoic membrane (CAM) neovascularization in vivo model were used to examine the effect of ART on angiogenesis induced by human myeloma cells. The results showed that ART could inhibit HUVECs migration, even at a lower concentration (3 μmol/l, P < 0.01, compared with the result of control group), and suppress efficiently the angiogenic ability of myeloma RPMI8226 cells in a dose-dependent pattern (3-12 μmol/l, P < 0.05). The levels of VEGF and Ang-1 in the conditioned medium (CM) were quantified by enzyme-linked immunosorbent assay (ELISA). The results confirmed that 3 μmol/l ART could significantly decrease VEGF and Ang-1 secretion by RPMI8226 cells (P < 0.05), which correlated well with the reduction of angiogenesis induced by myeloma RPMI8226 cells. The present study also showed that ART downregulated the expression of VEGF and Ang-1 in RPMI8226 cells and reduced the activation of extracellular signal-regulated kinase 1 (ERK1) as well. Therefore, ART can block ERK1/2 activation, downregulate VEGF and Ang-1 expression and inhibit angiogenesis induced by human multiple myeloma RPMI8226 cells. Combined with our previous published data, results from the present study indicate that ART possesses potential anti-myeloma effect.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells

et al. 2010

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“…Recently, tumor therapy by traditional Chinese herb is becoming more and more attractive (He et al, 2008;Youns et al, 2009;Chen et al, 2010). We therefore attempted to examine the effects of triptolide and artesunate on pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Synergism of Cytotoxicity Effects of Triptolide and Artesunate Combination Treatment in Pancreatic Cancer Cell Lines

Liu

Cui²

2013

Asian Pacific Journal of Cancer Prevention

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“…Beyond that, artesunate is considered for the treatment of malignancy [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27]. Its efficacy in malignancy may at least in part result from its ability to induce tumor cell apoptosis [13,14,23,25,26,28,29,30,31]. The proapoptotic effect has been attributed in part to mitochondria [23,25,29].…”

Section: Introductionmentioning

confidence: 99%

Stimulation of Suicidal Erythrocyte Death by Artesunate

Alzoubi

Calabrò

Bissinger

et al. 2014

Cell Physiol Biochem

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Background: The artemisinin derivative artesunate is effective in the treatment of severe malaria and is considered for the treatment of malignancy. Artesunate triggers tumor cell apoptosis, an effect at least in part mediated by mitochondria. Even though lacking mitochondria, erythrocytes may similarly enter suicidal death or eryptosis, which is characterized by cell shrinkage and breakdown of the phospholipid asymmetry of the cell membrane with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include increase of cytosolic Ca²⁺-activity ([Ca²⁺]_i), ceramide formation, and oxidative stress. The present study explored whether artesunate stimulates eryptosis. Methods: Phosphatidylserine exposure at the cell surface was estimated from annexin V binding, cell volume from forward scatter, [Ca²⁺]_i from Fluo3-fluorescence, ceramide abundance from binding of specific antibodies, and oxidative stress from 2′,7′-dichlorodihydrofluorescein-diacetate fluorescence. Results: A 48 h exposure of human erythrocytes to artesunate significantly increased the percentage of annexin-V-binding cells (≥ 9 µg/ml) without significantly influencing forward scatter. Artesunate significantly increased [Ca²⁺]_i. The stimulation of annexin-V-binding by artesunate (15 µg/ml) was significantly blunted but not abolished by removal of extracellular Ca²⁺. Artesunate increased the ceramide abundance at the cell surface and the 2′,7′-dichlorodihydrofluorescein-diacetate fluorescence. Conclusions: Artesunate stimulates phosphatidylserine translocation at the erythrocyte cell membrane, an effect at least partially due to increase of [Ca²⁺]_i, stimulation of ceramide formation and generation of oxidative stress.

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Progress in research on the anti-tumor effect of artesunate

Cited by 18 publications

References 12 publications

Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells

Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells

Synergism of Cytotoxicity Effects of Triptolide and Artesunate Combination Treatment in Pancreatic Cancer Cell Lines

Stimulation of Suicidal Erythrocyte Death by Artesunate

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