Progress in Synthesis of Pyrazolopyrimidinone

Abstract

Pyrazolopyrimidinone compounds are widely found in nature. Since the first pyrazolopyrimidinone was synthesized in 1888, synthesis and application of pyrazolopyrimidinones have been more and more active. Some pyrazolopyrimidinones are applied to the treatment of commom diseases, and are called the crown jewels in drug discovery history. For more than one century, various synthetic methodologies concerning pyrazolopyrimidinone have been developed. However, no specific review about pyrazolopyrimidinones was present. This review comments the synthesis of pyrazolopyrimidinone from the point of view of the synthetic methodology.

Synthesis and Fungicidal Activities of 2-Benzylsulfonyl-5-methyl- 1,2,4-triazolo[1,5-a]pyrimidine-7-oxoacetohydrazone Derivatives

“…砜类化合物具有广谱的生物活性, 在农药活性方面 被用于杀菌 [9] 、 杀虫 [10] 、 除草 [11] 和植物生长调节 [12] 等, 目 前已商品化的砜类农药有杀菌剂氧化萎锈灵、杀虫剂氟 虫 酰 胺 和 除 草 剂 磺 草 酮 等 . 此 外 , 酰 腙 类 化 合 物 (CONHN＝CH)容易与生物大分子形成多重氢键作用, 增强了与受体的结合力, 故表现出多种生物活性, 如杀 菌 [13] 、杀虫 [14] 和植物生长调节 [15] 等.…”