Progress in the application of reflectance confocal microscopy in dermatology

The Role of EREG, PTPN1, and SERPINB7 Genes in the Pathogenesis of Psoriasis: May SERPINB7 Be Protective and a Marker of Severity for Psoriasis?

“…Thus, both study showed that EREG is a vital stimulator of keratinocyte proliferation which is crucial feature of immunopathogenesis of psoriasis as well. Although we could not show expression levels of the EREG gene according to the layers of the skin, since it is known histopathologically that the spinous layer is hyperproliferated in psoriasis [ 17 ], it might be thought that overexpression of EREG gene seems to be related to this change. Our study supports these notions about EREG gene with the result of overexpressed EREG gene in the lesional skin of psoriatic patients.…”

Assessment of diagnostic accuracy of confocal image features used in detection of hypopigmented verruca plana on children's forehead and classic verruca plana in adult

“…RCM technology is a cost-effective tool in the diagnosis of VP. 5,6 Its use tests on 55 adult pigmented VPs and pointed out that the main features of petal-like structures had highly specific for VP without treatment. However, in their study, the petal-like structures probability by RCM was not very high, only 49.1% and 88.89% of patients had the disease for more than 1 year.…”

“…RCM technology is a cost‐effective tool in the diagnosis of VP. 5 , 6 Its use has been associated with increases in the diagnosis accuracy for VP and decreases in the number of unnecessary skin biopsies. In our study, we affirmed the diagnostic importance of RCM structures associated with VP detection.…”

Reflectance confocal microscopy clinical applications: Hypopigmented skin lesions in pediatric patients

“…Hypopigmented skin lesions have similar appearances and pose a diagnostic challenge for the clinician, dermoscopy is an useful technique to differential diagnosis, RCM is now believed to be a promising imaging technique for identification of hypopigmented skin diseases. 5,6 We evaluated vitiligo, nevus depigmentosus, lichen striatus, and lichen sclerosus and revealed specific confocal features to support clinical diagnosis and assist with patient management.…”