Progress in the studies on hormesis of low-dose pollutants

Shi, Junyi; Huber, Mitchell; Wang, Ting; Wang, Dali; Zhao, Lin; Yin, Chunyong

doi:10.4103/2468-5690.185296

Cited by 26 publications

(6 citation statements)

References 1 publication

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“…Conceptually, the stimulatory or paradoxically beneficial effects caused by the low exposure concentrations of agents can be referred to as hormesis . In toxicology, a hormetic dose response is a frequently documented phenomenon considering that the environmental exposure levels of pollutants are generally very low . The traditional threshold and linear models fail to accurately predict the toxicity of low chemical concentrations, which can be better fulfilled by the hormetic dose response model instead .…”

Section: Discussionmentioning

confidence: 99%

“…52 In toxicology, a hormetic dose response is a frequently documented phenomenon considering that the environmental exposure levels of pollutants are generally very low. 53 The traditional threshold and linear models fail to accurately predict the toxicity of low chemical concentrations, which can be better fulfilled by the hormetic dose response model instead. 54 Being independent of the biological model, the level of biological organization, inducing agents, and end points, hormesis is proposed to enable organisms to become well adapted or more tolerant to environmental challenges, ranging from low to moderate degree.…”

Section: Discussionmentioning

confidence: 99%

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Isothiazolinone Disrupts Reproductive Endocrinology by Targeting the G-Protein-Coupled Receptor Signaling

Tang,

Liu,

et al. 2024

Environ. Sci. Technol.

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The unintended exposure of humans and animals to isothiazolinones has led to an increasing concern regarding their health hazards. Isothiazolinones were previously found to disrupt reproductive endocrine homeostasis. However, the long-term reproductive toxicity and underlying mechanism remain unclear. In this study, life-cycle exposure of medaka to dichlorocthylisothiazolinone (DCOIT), a representative isothiazolinone, significantly stimulated the gonadotropin releasing hormone receptor (GnRHR)-mediated synthesis of follicle stimulating hormone and luteinizing hormone in the brain. Chem-Seq and proteome analyses revealed disturbances in the G-protein-coupled receptor, MAPK, and Ca 2+ signaling cascades by DCOIT. The G protein αi subunit was identified as the binding target of DCOIT. Gαi bound by DCOIT had an enhanced affinity for the mitochondrial calcium uniporter, consequently changing Ca 2+ subcellular compartmentalization. Stimulation of Ca 2+ release from the endoplasmic reticulum and blockage of Ca 2+ uptake into the mitochondria resulted in a considerably higher cytoplasmic Ca 2+ concentration, which then activated the phosphorylation of MEK and ERK to dysregulate hormone synthesis. Overall, by comprehensively integrating in vivo, ex vivo, in silico, and in vitro evidence, this study proposes a new mode of endocrine disrupting toxicity based on isothiazolinones, which is expected to aid the risk assessment of the chemical library and favor the mechanism-driven design of safer alternatives.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Isothiazolinone Disrupts Reproductive Endocrinology by Targeting the G-Protein-Coupled Receptor Signaling

Tang,

Liu,

et al. 2024

Environ. Sci. Technol.

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“…A similar hormetic effect of plastic particles has also been observed in crabs (Liu et al, 2019), algae (Gunasekaran et al, 2020), and oysters (Gardon et al, 2020). Among the more general mechanisms that have been suggested to underlie hormesis, leading hypotheses include protection against DNA damage, changes in gene expression and regulation, enhancement of immune function, and the fact that a given stressor may interact with different receptor subtypes, with higher affinity receptors promoting one metabolic change opposite to that of lower affinity subtypes (reviewed in Shi et al, 2016). Calabrese and Baldwin (2001) proposed that hormetic effects represent evolutionary‐based adaptive responses to environmentally induced disruptions in homeostasis, while other studies suggest a potential involvement of epigenetics in the process (reviewed in Vaiserman, 2011).…”

Section: Discussionmentioning

confidence: 99%

Nanoplastics modulate the outcome of a zooplankton–microparasite interaction

et al. 2023

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“…Observations of pine stand 'A' showed that the necrosis was, as a rule, shifted downward from the inoculation hole, or exhibited such a tendency (Figure 7). Another pattern was observed for pine Selye's syndrome is described by the 'hormesis' model, which suggests that low-dose effects induce activation of physiological functions; further chronic dose accumulation reduces the activating effect and evolves into an inhibitory (toxic) effect [31][32][33][34][35]. Probably, the increase in the size of needles in 2007 in pine stand 'A' allowed the trees to compensate the decrease in the productivity of photosynthesis when the needle surface was polluted and gas exchange was affected.…”

Section: The Stem Lesion Test (Inoculation Of the Trunk With The Fung...mentioning

confidence: 99%

Pine Stands as Bioindicators: Justification for Air Toxicity Monitoring in an Industrial Metropolis

et al. 2020

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Five permanent sample plots (SPs; 200–250 trees per plot) were established in middle-aged high-grade suburban pine stands near the industrial city of Krasnoyarsk, Siberia, Russia. Needle damage, inventory parameters of the stands, and the defense response of the stem phloem were evaluated annually for the years 2002–2019 and attributed to acute or chronic toxic exposures (creeping fire or industrial pollutants, respectively). The results form a basis for using trees as bioindicators. A newly elaborated stem lesion test was formed from a hypothesis on the upward sugar transport for the regeneration of an injured crown, based on Eschrich’s model of bidirectional sugar transport in the phloem. The formation of a phloem lesion was induced by inoculation of the stem with a mycelial extract of the ophiostomatoid fungus Ceratocystis laricicola. The lesion length and its shift relative to the inoculation hole were measured. An increase in the length of needles at early stages of stand weakening by pollutants was found to correspond to the hormesis model (Selye’s adaptation syndrome). A possibility of assessing the chronology of pollutant toxicity and the duration of the recovery period after creeping fire was shown.

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Progress in the studies on hormesis of low-dose pollutants

Cited by 26 publications

References 1 publication

Isothiazolinone Disrupts Reproductive Endocrinology by Targeting the G-Protein-Coupled Receptor Signaling

Isothiazolinone Disrupts Reproductive Endocrinology by Targeting the G-Protein-Coupled Receptor Signaling

Nanoplastics modulate the outcome of a zooplankton–microparasite interaction

Pine Stands as Bioindicators: Justification for Air Toxicity Monitoring in an Industrial Metropolis

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