Progress in the synthesis, characterisation, property enhancement techniques and application of gold nanoparticles: A review

Datta, Deepshikha; Deepak, K.S.; Das, Bimal

doi:10.1557/s43579-022-00216-2

Cited by 6 publications

(4 citation statements)

References 97 publications

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“…These substances are used in a variety of sectors including agricultural activities, sewage treatment, electronics, heavy metals adsorption, skincare industry, and medical practices, due to their distinctive characteristics ( Palani et al, 2021 ; Fouda et al, 2022 ). The fabrication of nanoparticles and nano-colloids has been achieved via biological, chemical, and physical processes ( Datta et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway

Alotaibi,

El-Masry,

Selim

et al. 2024

Front. Pharmacol.

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Section: Introductionmentioning

confidence: 99%

New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway

Alotaibi,

El-Masry,

Selim

et al. 2024

Front. Pharmacol.

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“…Studies of spherical gold nanoparticles (GNPs) have been focused on the structure and plasmonic properties of the particles as well as on their technological and biomedical applications (for reviews, see [1][2][3][4][5]). Many nanoparticle-based methods have been developed for the sensitive detection of biomolecules [6][7][8][9] as well as for the delivery of biomolecule-conjugated GNPs into cancer and other pathological cells [5,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Mostly driven by environmental concerns, the use of natural compounds for the preparation of gold nanoparticles ("green particles") has become popular nowadays (for recent reviews, see [2,3,31,32]). The main advantage of natural compounds over chemical ligands and synthetic polymers is that they are non-toxic, easily degradable, and in most cases inexpensive.…”

Section: Introductionmentioning

confidence: 99%

Ultrasmall ATP-Coated Gold Nanoparticles Specifically Bind to Non-Hybridized Regions in DNA

Katrivas,

Ben-Menachem,

Gupta

et al. 2023

Nanomaterials

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Here we report the synthesis of ultrasmall (2 nm in diameter) ATP-coated gold nanoparticles, ATP-NPs. ATP-NPs can be enlarged in a predictable manner by the surface-catalyzed reduction of gold ions with ascorbate, yielding uniform gold nanoparticles ranging in size from 2 to 5 nm in diameter. Using atomic force microscopy (AFM), we demonstrate that ATP-NPs can efficiently and selectively bind to a short non-hybridized 5A/5A region (composed of a 5A-nucleotide on each strand of the double helix) inserted into a circular double-stranded plasmid, Puc19. Neither small (1.4 nm in diameter) commercially available nanoparticles nor 5 nm citrate-protected ones are capable of binding to the plasmid. The unique ability to specifically target DNA regions characterized by local structural alterations of the double helix can pave the way for applications of the particles in the detection of genomic DNA regions containing mismatches and mutations that are common for cancer cells.

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“…Nanomaterials and nanocolloids can be manufactured by physical, chemical, and biological methods [8]. The biofabrication of nanomaterials using extracts of plants and microorganisms is very interesting for avoiding pressures, high temperatures, and hazardous chemicals.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

Fouda

Eid

Guibal³

et al. 2022

Applied Sciences

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The main challenge for researchers in the biomedical sectors concerns the development of new active compounds through cost-effectiveness, rapid, simple, and ecofriendly methods to overcome antibiotic resistance to pathogenic microbes. Herein, gold nanoparticles (AuNPs) were fabricated by a green approach through the reduction of chloroauric acid (HAuCl4) by harnessing the metabolites present in the aqueous extract of Zingiber officinale rhizome. UV-Vis spectroscopy, FT-IR, XRD, TEM, DLS, and zeta potential were used to characterize phytosynthesized AuNPs. In addition, the antimicrobial effect was investigated against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), unicellular fungi (Candida albicans), and multicellular fungi (Aspergillus brasiliensis). Antioxidant and in vitro cytotoxic activities were assessed. TEM and XRD showed the successful formation of spherical and crystalline structures, with sizes in the range of 5–53 nm (average size: 15.11 ± 8.5 nm). The zeta potential value (i.e., –28.8 mV) explains the high stability of synthesized AuNPs. AuNPs exhibit promising activity against prokaryotic and eukaryotic microorganisms with variable inhibition zones and low MIC values in the range of 25–6.25 µg mL−1. Phytosynthesized AuNPs exhibit DPPH scavenging activity with percentages of 87.6 ± 0.5% at a maximum concentration (1000 µg mL−1), which can be compared with ascorbic acid (97.3 ± 0.2%). Moreover, the AuNPs displayed a target-oriented effect for cancer cell lines HepG2 and MCF7 at low IC50 concentrations of 131.9 ± 9.34 and 288.23 ± 31.39 µg mL−1 compared to the normal oral epithelial OEC cell line (487.612 ± 3.53 µg mL−1). Overall, the phytosynthesized AuNPs show wide activities that enable their use in various biomedical and biotechnological applications.

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Progress in the synthesis, characterisation, property enhancement techniques and application of gold nanoparticles: A review

Cited by 6 publications

References 97 publications

New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway

New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway

Ultrasmall ATP-Coated Gold Nanoparticles Specifically Bind to Non-Hybridized Regions in DNA

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

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