Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment

Dai, Huan; Liu, Haobiao; Yang, Zhihao; Bao, Miaoye; Lin, Xue; Han, Jing; Qu, Chengjuan

doi:10.1007/s12011-021-03022-4

Cited by 21 publications

(12 citation statements)

References 116 publications

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“…Similar to Keshan disease, Kashin‐Beck disease is an endemic disease that often manifests as cartilage joint deformation and is prevalent in northwest China. At present, the specific pathogenic factors of Keshan disease are unclear, but the incidence areas are mainly concentrated in Se deficiency zones (Deng et al ., 2021). The Se content of patients with Keshan disease is dramatically lower than that of residents in areas with normal Se content, and the occurrence of Keshan disease can be prevented by orally taking sodium selenite, indicating that the pathogenesis of Keshan disease is related to Se (Zhu et al ., 2019).…”

Section: Physiological Functions Of Sementioning

confidence: 99%

Selenium and selenoproteins: their function and development of selenium‐rich foods

Han

Liu

2022

Int J of Food Sci Tech

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Summary Selenium (Se) is a nutrient related to human physiological processes and an essential trace element that has attracted considerable attention because of its antioxidant, immune and other functions. Se deficiency can cause all sorts of diseases and dysfunctions in the human tissues, but excessive intake of Se can also cause poisoning and injury. With lower toxicity and higher utilisation than inorganic Se, organic Se is recommended in the framework of a balanced diet. Compared with pharmaceutical supplementation, dietary Se supplementation is more acceptable to the masses. Thus, Se‐rich foods and selenoproteins enriched with organic Se have become a hot spot for current research. In living organisms, Se often exists in the form of selenoproteins (more than 25); for example, selenocysteine and selenomethionine are the common chemical forms of Se amino acids. And most of Se's physiological functions depend on the participation of selenoproteins. This paper reviews the physiological processes of Se, the development and utilisation of Se‐enriched foods, and the research on the properties of selenoproteins. Some suggestions and prospects for developing Se‐rich food in the future are also provided.

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Section: Physiological Functions Of Sementioning

confidence: 99%

Selenium and selenoproteins: their function and development of selenium‐rich foods

Han

Liu

2022

Int J of Food Sci Tech

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“…Selenium is associated with the normal function of glutathione protein (GSH) and its family of antioxidant enzymes such as glutathione peroxidase (GPx), thioredoxin reductase (TrxR) and other selenoproteins ( 3 ). The lack of Se can severely affect the human immune system ( 4 , 5 ), leading to a cardiomyopathy disorder called “Keshan disease” and the bone and joint connection syndrome called “Kashin-Beck disease” ( 6 , 7 ). Keshan disease occurs when vascular endothelial cells are damaged from oxidative stress due to non-functional antioxidant proteins ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Selenium-enriched plant foods: Selenium accumulation, speciation, and health functionality

et al. 2023

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Selenium (Se) is an essential element for maintaining human health. The biological effects and toxicity of Se compounds in humans are related to their chemical forms and consumption doses. In general, organic Se species, including selenoamino acids such as selenomethionine (SeMet), selenocystine (SeCys2), and Se-methylselenocysteine (MSC), could provide greater bioactivities with less toxicity compared to those inorganics including selenite (Se IV) and selenate (Se VI). Plants are vital sources of organic Se because they can accumulate inorganic Se or metabolites and store them as organic Se forms. Therefore, Se-enriched plants could be applied as human food to reduce deficiency problems and deliver health benefits. This review describes the recent studies on the enrichment of Se-containing plants in particular Se accumulation and speciation, their functional properties related to human health, and future perspectives for developing Se-enriched foods. Generally, Se’s concentration and chemical forms in plants are determined by the accumulation ability of plant species. Brassica family and cereal grains have excessive accumulation capacity and store major organic Se compounds in their cells compared to other plants. The biological properties of Se-enriched plants, including antioxidant, anti-diabetes, and anticancer activities, have significantly presented in both in vitro cell culture models and in vivo animal assays. Comparatively, fewer human clinical trials are available. Scientific investigations on the functional health properties of Se-enriched edible plants in humans are essential to achieve in-depth information supporting the value of Se-enriched food to humans.

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“…21 It is present in the amino acid selenocysteine (Sec), which eventually forms selenoproteins for various enzymes. 22 In addition, Se can neutralize the toxic effect of heavy metals, such as arsenic and lead. 23 It is also known to have antioxidant and anticancer properties.…”

Section: Introductionmentioning

confidence: 99%

Selenite-Incorporated Amorphous Calcium–Magnesium Carbonate Nanoparticles Reduce Bacterial Growth

Göçtü,

Oral,

Ercan

2023

ACS Appl. Nano Mater.

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Amorphous calcium carbonate (ACC) is a nontoxic and degradable nanomaterial. ACC can be synthesized using the coprecipitation technique, which enables the incorporation of ions into its amorphous structure. Although ACC has been investigated for various applications, such as wastewater treatment, in vivo imaging, and drug delivery, its antibacterial properties have not been explored. Considering the extraordinary capability of bacteria to adapt antimicrobial strategies, as well as the extensive burden of bacteria-induced problems on healthcare systems and the world economy, the need for effective antibacterial agents is becoming a pressing issue. Herein, we introduced selenite-incorporated magnesium-stabilized amorphous calcium carbonate (ACMC) nanoparticles as a sustainable antibacterial material. For the first time, we demonstrated that selenite ions could be incorporated into ACMC nanoparticles while preserving the amorphous structure. Antibacterial activity analysis showed that selenite-incorporated ACMC (Se-ACMC) nanoparticles at 1 g/L concentration could significantly reduce the growth of Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria strains within 24 h of interaction. As an important observation, even the lowest selenite incorporation (4.38 ± 0.19 mg selenium per g of nanoparticles) led to a more than 3-log reduction in the number of S. epidermidis colonies. Additionally, the antibacterial activity was enhanced with an increase in the amount of incorporated selenite. These results indicated that ion-incorporated ACMC nanoparticles can pave the way for applications as antibacterial agents.

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Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment

Cited by 21 publications

References 116 publications

Selenium and selenoproteins: their function and development of selenium‐rich foods

Selenium and selenoproteins: their function and development of selenium‐rich foods

Selenium-enriched plant foods: Selenium accumulation, speciation, and health functionality

Selenite-Incorporated Amorphous Calcium–Magnesium Carbonate Nanoparticles Reduce Bacterial Growth

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