Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified

Hsu, Tien; Steeg, Patricia S.; Zollo, Massimo; Wieland, Thomas

doi:10.1007/s00210-014-1079-9

Cited by 16 publications

(14 citation statements)

References 101 publications

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“…41 If for liver, breast, colon and lung carcinoma as well as for melanoma, the vast majority of studies reported an inverse correlation with metastasis and/or poor overall survival (Leonard et al, 91 next issue), this is less marked in gastric and ovarian carcinoma, for which disparate results were found. 88,92 In other types of cancers such as neuroblastoma, hematopoietic malignancies, and osteosarcoma, high tumoral expression was noted, which was most often correlated with poor outcome (Tan and Chang, 93 this issue). The conflicting data described in the literature, might be due, at least partially, to the presence of the two closely related isoforms NME1 and NME2, which are most often not discriminated by antibodies and probes; heterogeneous expression in the primary tumors; and/or the criteria used to evaluate and grade NME1 expression in human clinical samples.…”

Section: Nme In Metastasismentioning

confidence: 99%

The NDPK/NME superfamily: state of the art

Boissan

Schlattner

Lacombe

2018

Laboratory Investigation

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Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded proteins are catalytically active NDPKs and that NM23 generally refers to clinical studies on metastasis, we use here NME/NDPK to denote the proteins. Since their discovery in the 1950's, NMEs/NDPKs have been shown to be involved in multiple physiological and pathological cellular processes, but the molecular mechanisms have not been fully determined. Recent progress in elucidating these underlying mechanisms has been presented by experts in the field at the 10th International Congress on the NDPK/NME/AWD protein family in October 2016 in Dubrovnik, Croatia, and is summarized in review articles or original research in this and an upcoming issue of Laboratory Investigation. Within this editorial, we discuss three major cellular processes that involve members of the multi-functional NME/NDPK family: (i) cancer and metastasis dissemination, (ii) membrane remodeling and nucleotide channeling, and iii) protein histidine phosphorylation.

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Section: Nme In Metastasismentioning

confidence: 99%

The NDPK/NME superfamily: state of the art

Boissan

Schlattner

Lacombe

2018

Laboratory Investigation

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“…28,32 For a more detailed overview of these mechanisms, the reader is referred to previous reviews. [33][34][35][36] Although NDPK-C can activate G proteins similar to NDPK-B (discussed below), other potential NDPK-C phosphorylation targets have not yet been identified.…”

Section: Mechanisms Of G-protein Signaling Regulation By Ndpksmentioning

confidence: 99%

Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update

Abu-Taha

Heijman

Feng

et al. 2018

Laboratory Investigation

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Heterotrimeric G proteins are pivotal mediators of cellular signal transduction in eukaryotic cells and abnormal G-protein signaling plays an important role in numerous diseases. During the last two decades it has become evident that the activation status of heterotrimeric G proteins is both highly localized and strongly regulated by a number of factors, including a receptor-independent activation pathway of heterotrimeric G proteins that does not involve the classical GDP/GTP exchange and relies on nucleoside diphosphate kinases (NDPKs). NDPKs are NTP/NDP transphosphorylases encoded by the nme/nm23 genes that are involved in a variety of cellular events such as proliferation, migration, and apoptosis. They therefore contribute, for example, to tumor metastasis, angiogenesis, retinopathy, and heart failure. Interestingly, NDPKs are translocated and/or upregulated in human heart failure. Here we describe recent advances in the current understanding of NDPK functions and how they have an impact on local regulation of G-protein signaling.

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“…Metastasis, the colonization of distant sites by a tumor, is often more life threatening than the growth of the primary tumor, which can be surgically removed in many cases. Thus, the identification of the function of Nme1 underlying its metastasis suppressor activity is a long standing goal in research [1].…”

Section: Issam H Abu-taha Christiane Vettel and Thomas Wielandmentioning

confidence: 99%

Untitled

2018

Oncotarget

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Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified

Cited by 16 publications

References 101 publications

The NDPK/NME superfamily: state of the art

The NDPK/NME superfamily: state of the art

Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update

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