Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins

Cui, Hongyuan; Zhang, Yaxian; Zhang, Leiliang

doi:10.3389/fimmu.2021.740223

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…Most of these domains contain an F-box domain at the C-terminal region and multiple ANKs at N-terminal region. The cellular F-box motif is usually associated with ubiquitin ligase E3 complexes involved in the ubiquitination of specific protein ( Bai et al., 1996 ; Cardozo and Pagano, 2004 ; Cui et al., 2021 ). F-box proteins can bind to SCF complexes, including Skp1, Cullin1 and Rbx1.…”

Section: The Host Range Genes Of Poxvirusmentioning

confidence: 99%

Cross-species transmission and host range genes in poxviruses

Yang,

Song,

Qiu

et al. 2024

Virologica Sinica

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Section: The Host Range Genes Of Poxvirusmentioning

confidence: 99%

Cross-species transmission and host range genes in poxviruses

Yang,

Song,

Qiu

et al. 2024

Virologica Sinica

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“…The ubiquitin proteasome system (UPS) is the most critical non-lysosomal protein degradation mechanism in eukaryotic cells [ 8 ]. Ubiquitin consists of 76 amino acids and is a highly conserved protein expressed in all eukaryotic cells [ 9 , 10 ]. Ubiquitination is the covalent binding of ubiquitin to substrate proteins catalyzed by E1-activating enzymes, E2-binding enzymes, and E3 ligases [ 11 ] and is essential for the maintenance of intracellular homeostasis.…”

Section: Introductionmentioning

confidence: 99%

FBXO28 promotes proliferation, invasion, and metastasis of pancreatic cancer cells through regulation of SMARCC2 ubiquitination

Liu,

Zhu

et al. 2023

Aging

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The E3 ligase F-box only protein 28 (FBXO28) belongs to the F-box family of proteins that play a critical role in tumor development. However, the potential function of FBXO28 in pancreatic cancer (PC) and its molecular mechanism remain unclear. In this study, we examined FBXO28 expression in PC and its biological role and explored the mechanism of FBXO28-mediated proliferation, invasion, and metastasis of PC cells. Compared with paracancerous tissues and human normal pancreatic ductal epithelial cells, FBXO28 was highly expressed in PC tissues and cell lines. High expression of FBXO28 was negatively correlated with the survival prognosis of patients with PC. Functional assays indicated that FBXO28 promoted PC cell proliferation, invasion, and metastasis in vitro and in vivo. Furthermore, immunoprecipitation-mass spectrometry was used to identify SMARCC2 as the target of FBXO28; upregulation of SMARCC2 can reverse the effect of overexpression of FBXO28 on promoting the proliferation, invasion, and metastasis of PC cells. Mechanistically, FBXO28 inhibited SMARCC2 expression in posttranslation by increasing SMARCC2 ubiquitination and protein degradation. In conclusion, FBXO28 has a potential role in PC, possibly promoting PC progression through SMARCC2 ubiquitination. Thus, FBXO28 might be a potential treatment target in PC.

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Poxviral ANKR/F-box Proteins: Substrate Adapters for Ubiquitylation and More

2022

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Poxviruses are double-stranded DNA viruses that infect insects and a variety of vertebrate species. The large genomes of poxviruses contain numerous genes that allow these viruses to successfully establish infection, including those that help evade the host immune response and prevent cell death. Ankyrin-repeat (ANKR)/F-box proteins are almost exclusively found in poxviruses, and they function as substrate adapters for Skp1-Cullin-1-F-box protein (SCF) multi-subunit E3 ubiquitin (Ub)-ligases. In this regard, they use their C-terminal F-box domain to bind Skp1, Cullin-1, and Roc1 to recruit cellular E2 enzymes to facilitate the ubiquitylation, and subsequent proteasomal degradation, of proteins bound to their N-terminal ANKRs. However, these proteins do not just function as substrate adapters as they also have Ub-independent activities. In this review, we examine both Ub-dependent and -independent activities of ANKR/F-box proteins and discuss how poxviruses use these proteins to counteract the host innate immune response, uncoat their genome, replicate, block cell death, and influence transcription. Finally, we consider important outstanding questions that need to be answered in order to better understand the function of this versatile protein family.

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Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins

Cited by 3 publications

References 42 publications

Cross-species transmission and host range genes in poxviruses

Cross-species transmission and host range genes in poxviruses

FBXO28 promotes proliferation, invasion, and metastasis of pancreatic cancer cells through regulation of SMARCC2 ubiquitination

Poxviral ANKR/F-box Proteins: Substrate Adapters for Ubiquitylation and More

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