Progress on the Clinical Applications of Stem Cells for Thin Endometrium

Abstract

Thin endometrium (TE) is a heterogeneous uterine disorder characterized by TE that results in infecundity. Patients with TE are usually associated with menstrual abnormalities and suffer from pelvic pain. A number of treatments have been employed to promote endometrial growth, but none has been validated effective. With the development of stem cell therapy, better means for TE treatment to improve endometrium, thus restoring its function become possible. Studies in TE mouse models have shown that stem cell implantation could improve pregnancy. However, the efficiency is relatively low and the safety for its clinical applications remains unclear. Here, we summarize recent progresses on the clinical application of stem cells for TE treatment, which would provide valuable references for stem cell therapy in TE patients.