2024
DOI: 10.2174/9789815179842124120008
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Progress on the Development of Oxime Derivatives as a Potential Antidote for Organophosphorus Poisoning

Manjunatha S. Katagi,
M.L Sujatha,
Girish Bolakatti
et al.

Abstract: Nowadays, organophosphorus poisoning is the most common emergency throughout the world. Two functionally different types of drugs are used in common to treat such intoxication cases. The first type includes the reactivators of acetylcholinesterase (AChE)-oximes, which have the capability to restore the physiological function of inhibited AChE. The second type includes anticholinergic, such as atropine that antagonizes the effects of excessive ACh by blocking muscarinic receptors. Alternatively, anticholinergic… Show more

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