Progression Detection Capability of Macular Thickness in Advanced Glaucomatous Eyes

Sung, Kyung Rim; Sun, Jianhong; Na, Jung Hwa; Lee, Jin Young; Lee, Youngrok

doi:10.1016/j.ophtha.2011.08.022

Cited by 131 publications

(90 citation statements)

References 33 publications

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“…These results suggest that detection of glaucoma progression with RNFL thickness and rim area and thickness as determined by Cirrus HD-OCT may have limited clinical value; other studies also reported that glaucoma progression detection by RNFL thickness or rim area as measured by Cirrus HD-OCT may be less effective than visual field test or macular thickness measurement, especially in advanced glaucoma. 17,22 When the RNFL thickness and rim area and thickness of mild glaucoma and moderate to advanced glaucoma groups were compared, significant differences were found in RNFL thicknesses of global area and superior, inferior, and temporal quadrants, whereas no significant differences were evident in rim area and thickness in all areas. These results imply that neuroretinal rim may not be changed in accordance with a decrease in RNFL thickness with respect to the stages of glaucomatous damage.…”

Section: Discussionmentioning

confidence: 99%

Glaucoma Diagnostic Ability of Quadrant and Clock-Hour Neuroretinal Rim Assessment Using Cirrus HD Optical Coherence Tomography

Hwang

Kim

2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The aim of this study was to investigate the glaucoma diagnostic ability of quadrant and clock-hour neuroretinal rim assessment by Cirrus HD spectral-domain optical coherence tomography (OCT).METHODS. Eighty eyes of 80 glaucoma patients and 80 eyes of 80 healthy subjects were enrolled. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Cirrus HD-OCT. Quadrant and clock-hour rim areas and thicknesses were obtained from optic nerve head images and 3608 circumferential rim thickness curve of Cirrus HD-OCT, respectively. Area under receiver operating characteristic curves (AUCs) and sensitivities of RNFL thicknesses, rim areas, and rim thicknesses at a 90% specificity level were calculated.RESULTS. Quadrant and clock-hour rim area and thickness showed good diagnostic ability for glaucoma in all areas (AUCs, 0.877-0.969; sensitivities, 67.5%-96.3%). When the AUCs of RNFL thicknesses, rim areas, and rim thicknesses were compared, no significant difference was found in global area and superior and inferior quadrants (P > 0.05). However, in nasal and temporal quadrants, rim area and thickness had greater AUCs (AUCs, 0.919-0.945; sensitivities, 82.5%-86.3%) than RNFL thickness (AUCs, 0.749-0.776; sensitivities, 12.5%-33.8%; P < 0.001). Eyes with moderate to advanced glaucoma (mean deviation < -6 dB) had thinner RNFL than mild glaucoma (mean deviation ‡ -6 dB) in global area, superior, inferior, and temporal quadrants (P < 0.003); rim area and thickness showed no significant difference in all areas (P > 0.003).CONCLUSIONS. Neuroretinal rim assessment in nasal and temporal areas by Cirrus HD-OCT may enhance glaucoma diagnostic ability. RNFL and rim changes measured by Cirrus HD-OCT may be different according to the stages of glaucomatous damage. (Invest Ophthalmol Vis Sci.

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Section: Discussionmentioning

confidence: 99%

Glaucoma Diagnostic Ability of Quadrant and Clock-Hour Neuroretinal Rim Assessment Using Cirrus HD Optical Coherence Tomography

Hwang

Kim

2012

Invest. Ophthalmol. Vis. Sci.

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“…Details of the manner in which TMT and cRNFL thickness measurements are conducted have been reported previously. 5,6,42 Glaucoma progression in each eye was determined by linear regression against patient age using serial TMT, cRNFL, and three segmented macular layer (MNFL, GCA, and ORL) thickness measurements. A significantly negative slope (P < 0.05) indicated progression as evidenced by analysis of that parameter.…”

Section: Sd-oct Assessmentmentioning

confidence: 99%

Detection of Glaucoma Progression by Assessment of Segmented Macular Thickness Data Obtained Using Spectral Domain Optical Coherence Tomography

Sung

Baek

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.We evaluated the clinical use of segmented macular layer thickness measurement in terms of glaucoma diagnosis and the ability to detect progression, and to compare such outcomes to those by circumpapillary retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements.METHODS. The study included 141 glaucomatous and 61 healthy eyes. All glaucomatous eyes were subjected to at least four spectral domain optical coherence tomography (SD-OCT) examinations (mean follow-up, 2.13 years). Segmented macular layers were the macular nerve fiber layer (NFL), ganglion cell and inner plexiform layer (GCA), and outer retinal layer (ORL; from outer plexiform layer to retinal pigment epithelium). Areas under receiver operating characteristic curves (AUCs) discriminating healthy from glaucomatous eyes were determined in baseline measurements. The sensitivity and specificity of these parameters in terms of glaucoma progression detection were determined, with reference to assessment of optic disc/retinal nerve fiber layer (RNFL) photographs/visual field (VF) deterioration as standard(s).RESULTS. GCA afforded the best diagnostic performance among three macular layers. The AUC of the GCA thickness (GCAT) was less than that of cRNFLT (0.869 vs. 0.953, P ¼ 0.018), but superior to that of TMT (0.790, P ¼ 0.05). Of the eyes, 38 showed progression during follow-up by standard methods. The sensitivities of TMT, GCAT, and cRNFLT values in terms of detection of progression were 14%, 8%, and 5%, respectively.CONCLUSIONS. Although baseline cRNFL measurement was optimal in terms of glaucoma diagnosis, the GCAT and TMT showed similar levels of sensitivity in progression detection. (Invest Ophthalmol Vis Sci. 2012;53:3817-3826)

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“…Use of novel structural tests may improve clinical diagnosis, since for early glaucomatous visual field damage to be detected approximately 30 % of the retinal ganglion cells need to be lost [1]. Retinal nerve fiber layer (RNFL) thickness parameters of Fourier-domain (FD) optical coherence tomography (OCT) are believed to have diagnostic accuracy [2][3][4][5][6][7][8]; however, inner macular thickness parameters, which comprise tissue layers directly influenced by glaucomatous ganglion cell loss, show comparable or even higher diagnostic accuracy, particularly in detection of very early glaucoma, and in myopic eyes [9][10][11][12][13][14][15]. The RTVue-100 OCT (Optovue Inc., Fremont, CA, USA) is a new FD OCT systems.…”

Section: Introductionmentioning

confidence: 99%

“…The RTVue-100 OCT (Optovue Inc., Fremont, CA, USA) is a new FD OCT systems. It has been evaluated in detail for clinical usefulness, detection of glaucoma and glaucomatous structural progression [2,3,10,16]. Structure-function relationship has also been established for several parameters of this FD OCT [14,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Comparison of macular ganglion cell complex thickness to total retinal thickness ratio between Hungarian and Japanese eyes

et al. 2013

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Progression Detection Capability of Macular Thickness in Advanced Glaucomatous Eyes

Cited by 131 publications

References 33 publications

Glaucoma Diagnostic Ability of Quadrant and Clock-Hour Neuroretinal Rim Assessment Using Cirrus HD Optical Coherence Tomography

Glaucoma Diagnostic Ability of Quadrant and Clock-Hour Neuroretinal Rim Assessment Using Cirrus HD Optical Coherence Tomography

Detection of Glaucoma Progression by Assessment of Segmented Macular Thickness Data Obtained Using Spectral Domain Optical Coherence Tomography

Comparison of macular ganglion cell complex thickness to total retinal thickness ratio between Hungarian and Japanese eyes

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