Progression level of extracapsular spread and tumor budding for cervical lymph node metastasis of OSCC

Yamada, Shin‐ichi; Otsuru, Mitsunobu; Yanamoto, Souichi; Hasegawa, Takumi; Aizawa, Hitoshi; Kamata, Toshihide; Yamakawa, Nobuhiro; Kohgo, Tomoyuki; Ito, Akira; Noda, Yuri; Hirai, Chihoko; Kitamura, Tatsuya; Okura, Masaya; Kirita, Tadaaki; Yamashita, Tetsuro; Ota, Yoshihide; Komori, Takahide; Umeda, Masahiro; Kitamura, Hiroshi

doi:10.1007/s00784-017-2231-y

Cited by 17 publications

(23 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accumulating evidences have implicated tumor budding as a strong and valuable independent prognostic factor in many solid cancers . Moreover, evaluation of tumor budding in biopsy specimens also might provide useful prognostic information, indicating a promising clinical application for patient diagnosis and treatment .…”

Section: Discussionmentioning

confidence: 99%

“…Those budding cells represent a phenotype undergoing epithelial‐mesenchymal transition (EMT) or dedifferentiation . Accumulating evidence indicates that tumor budding is a valuable prognostic marker in many solid tumors due to it is correlated with more aggressive behavior and poor prognosis . In our previous studies, we found that tumor budding was an independent prognostic factor for OTSCC patients, particularly in T1/T2 stage .…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma

Xie

Liu

et al. 2019

J Oral Pathology Medicine

View full text Add to dashboard Cite

Background Tumor budding is a valuable prognostic marker in oral tongue squamous cell carcinoma (OTSCC) but lacks a standardized scoring system. The aim of this study was to evaluate the prognostic value of tumor budding for OTSCC patients based on the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016. Methods Tumor budding was scored as ITBCC recommended in 255 patients with OTSCC. Then, associations between tumor budding and clinicopathologic parameters were examined. Among them, 136 patients with follow‐up data available were used to evaluate overall survival (OS) by the Kaplan‐Meier method. Prognostic value of tumor budding was assessed by Cox regression analysis. The inter‐observer and intra‐observer agreement was calculated by the kappa statistic. Results Tumor budding score was associated with lymph node metastasis, differentiation, invasive pattern, lymphoid infiltrate, tumor relapse, invasive depth, and reduced OS in OTSCC patients. The Cox analysis showed high budding score was an independent prognostic factor in patients with all clinical stage and patients with clinical early‐stage OTSCC. The high kappa values were achieved in intra‐observer and inter‐observer. Conclusions International Tumor Budding Consensus Conference scoring system is a simple, reliable, and reproducible method to measure tumor budding in OTSCC, which should be included in the routine pathological report.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma

Xie

Liu

et al. 2019

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Multivariate analysis in our study demonstrated that TB and ENE were significant independent predictors of LN recurrence (Table ). The study of Yamada et al proposed that the progression level of ENE and TB are useful prognostic factors in patients with OSCC . They divided the progression level of ENE into three types; type C, which was microscopically defined as tumor invasion to perinodal fat or muscle tissue, was associated with poorer prognoses based on the analyses of OS and RFS rates .…”

Section: Discussionmentioning

confidence: 99%

The significance of tumor budding in oral cancer survival and its relevance to the eighth edition of the American Joint Committee on Cancer staging system

Cheng

et al. 2019

Head & Neck

View full text Add to dashboard Cite

Background To explore the clinicopathological significance of tumor budding (TB) on oral squamous cell carcinoma (OSCC) prognosis. Methods Data of 200 patients with OSCC were retrieved from the cancer registration database in Taipei Veterans General Hospital. Clinicopathological characteristics and survival relevant to TB were analyzed. Results The data showed that TB was predominant in the tongue and floor of the mouth in younger patients with OSCC and correlated with several pathological factors, such as perineural invasion and lymphovascular invasion. Patients with TB have significantly lower recurrence‐free survival (P ≤ .0001). TB was significantly associated with lymph node metastasis in patients with early cancer stage (P = .042). Multivariate analysis demonstrated extranodal extension and TB as independent predictors of lymph node recurrence (adjusted hazard ratio = 9.90 and 3.89, respectively). Conclusion TB is a significant predictor of tumor aggression with locoregional failure even in the revised 8th American Joint Committee on Cancer staging system.

show abstract

“…Second, the level of ENE progression was not investigated in this study. The pathological level of ENE progression may be an important factor for predicting prognoses and the application of adjuvant therapy, although it is controversial . Previously, we demonstrated that DSS and RFS rates were significantly lower in patients with type C level of ENE progression, which was defined as microscopic tumor invasion into the perinodal fat or muscle tissue, than in patients with the other two types .…”

Section: Discussionmentioning

confidence: 90%

Multi‐center retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with single lymph node metastasis and extra nodal extension

Hasegawa

Yanamoto

Otsuru

et al. 2018

Journal of Surgical Oncology

Self Cite

View full text Add to dashboard Cite

show abstract

Progression level of extracapsular spread and tumor budding for cervical lymph node metastasis of OSCC

Abstract: This study indicated that the progression level and tumor budding of ECS for cervical lymph node metastasis were useful prognostic factors in OSCC patients.

Cited by 17 publications

References 33 publications

Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma

Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma

The significance of tumor budding in oral cancer survival and its relevance to the eighth edition of the American Joint Committee on Cancer staging system

Multi‐center retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with single lymph node metastasis and extra nodal extension

Contact Info

Product

Resources

About