Progressive biparietal atrophy: an atypical presentation of Alzheimer's disease.

Ross, Sarah J.; Graham, Naida L.; Stuart-Green, L; Prins, Marloes; Xuereb, John H.; Patterson, Karalyn; Hodges, John R.

doi:10.1136/jnnp.61.4.388

Cited by 164 publications

(104 citation statements)

References 33 publications

(16 reference statements)

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“…That is, the dorsal (or biparietal) and ventral (or occipitotemporal) subtypes [4], and the primary visual subtype in addition to the above two [3]. Nevertheless, our patient could not be classified into any of the existing subtypes.…”

Section: Discussionmentioning

confidence: 93%

“…However, symptoms of recently reported PCA have been examined in a more comprehensive manner [2] and grouped into two or three subtypes according to regions of atrophy or hypoperfusion [3]. The most widely accepted classification involves a dichotomy of ventral type versus dorsal type [4]. The observed characteristics of the ventral type were visual object agnosia, topographical agnosia, and alexia; those of the dorsal type were Bálint syndrome and dressing apraxia [3, 5].…”

Section: Introductionmentioning

confidence: 99%

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Residual Perception of Moving Objects: Dissociation of Moving and Static Objects in a Case of Posterior Cortical Atrophy

Midorikawa

Nakamura²,

Nagao³

et al. 2008

Eur Neurol

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Background/Aims: Several studies have reported specific cognitive deficits of posterior cortical atrophy (PCA) starting in the early stage; however, these characteristics have not been demonstrated as arising in the middle or late stage of the disease. We report a patient with PCA who exhibited atypical symptoms after the middle stage. Methods: We observed and examined the patient for more than 10 years in clinical and everyday situations. Results: With increasing symptoms, the patient gradually showed blind-like behavior. He could not find a static object even when it was in front of him, but he could see and catch a tossed ball very well. In addition, he could walk and pick up scattered golf balls without colliding with obstacles. Magnetic resonance imaging and single photon emission computed tomography indicated severe degeneration in the white matter of the parietal lobe and lateral occipital region, whereas the primary visual cortex was relatively intact. Conclusion: Several studies have reported specific cognitive deficits in PCA; however, the present results support the conclusion that not only the initial stage but also the middle and late stages of the disease have the potential to disturb specific cognitive systems.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Residual Perception of Moving Objects: Dissociation of Moving and Static Objects in a Case of Posterior Cortical Atrophy

Midorikawa

Nakamura²,

Nagao³

et al. 2008

Eur Neurol

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“…In PCA two different phenotypes have been described reflecting either damage of the dorsal or ventral visual pathways [17,34,37]. Degeneration of structures in the dorsal occipito-parietal stream, the "where pathway", is associated with visuo-spatial deficits, Balint's syndrome, transcortical sensory aphasia, apraxia, elements of the Gerstmann's syndrome, whereas the degeneration of areas in the ventral occipito-temporal stream, the "what pathway", causes alteration in the visual perception of objects, apperceptive visual agnosia, alexia and prosopoagnosia.…”

Section: Introductionmentioning

confidence: 99%

Visuo-Spatial Imagery Impairment in Posterior Cortical Atrophy: A Cognitive and SPECT Study

Gardini

Concari

Pagliara³

et al. 2011

Behavioural Neurology

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Abstract. This study investigated the cognitive profile and the cerebral perfusion pattern in a highly educated 70 year old gentleman with posterior cortical atrophy (PCA). Visuo-perceptual abilities, spatial memory, spatial representation and navigation, visuospatial mental imagery, semantic and episodic-autobiographical memory were assessed. Regional cerebral blood flow (rCBF) was imaged with SPECT. Cognitive testing showed visual-perceptual impairment, apperceptive visual and landmark agnosia, topographical disorientation with way-finding deficits, impaired map learning and poor mental image generation. Semantic memory was normal, while episodic-autobiographical memory was impaired. Reduced rCBF was found mainly in the right hemisphere, in the precentral gyrus, posterior cingulate and middle temporal gyri, cuneus and precuneus, in the left superior temporal and lingual gyri and in the parahippocampus bilaterally. Hypoperfusion in occipito-parietal regions was associated with visuo-spatial deficits, whereas deficits in visuo-spatial mental imagery might reflect dysfunction related to hypoperfusion in the parahippocampus and precuneus, structures which are responsible for spatial and imagery processing. Dissociating performance between preserved semantic memory and poor episodic-autobiographical recall is consistent with a pattern of normal perfusion in frontal and anterior temporal regions but abnormal rCBF in the parahippocampi. The present findings indicate that PCA involves visuo-spatial imagery deficits and provide further validation to current neuro-cognitive models of spatial representation and topographical disorientation.

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“…Caine and Hodges [114] carried out two separated studies to investigate ventral and dorsal visual functions in a sample of AD patients at early stages of the disease. A small subsample of patients were impaired on visuospatial tasks, thus suggesting that this small group of patients with prominent visuospatial disorders might represent one end of a continuous spectrum at the other end of which are patients affected by a focal degenerative dementia involving occipito-parietal cortex, the so-called PCA [115][116][117][118]. In the moderate stages of AD, visuospatial impairments would become more evident, and play a relevant role in the development of constructional disorders [89].…”

Section: Drawing Disorders In Different Stages Of Evolution Of Admentioning

confidence: 99%

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Trojano

Gainotti

2016

JAD

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Abstract. Drawing is a multicomponential process that can be impaired by many kinds of brain lesions. Drawing disorders are very common in Alzheimer's disease and other forms of dementia, and can provide clinical information for the distinction of the different dementing diseases. In our review we started from an overview of the neural and cognitive bases of drawing, and from a recollection of the drawing tasks more frequently used for assessing individuals with dementia. Then, we analyzed drawing disorders in dementia, paying special attention to those observed in Alzheimer's disease, from the prodromal stages of the amnesic mild cognitive impairment to the stages of full-blown dementia, both in the sporadic forms with late onset in the entorhino-hippocampal structures and in those with early onset in the posterior neocortical structures. We reviewed the drawing features that could differentiate Alzheimer's disease from vascular dementia and from the most frequent forms of degenerative dementia, namely frontotemporal dementia and Lewy body disease. Finally, we examined some peculiar aspects of drawing disorders in dementia, such as perseverations, rotations, and closing-in. We argue that a careful analysis of drawing errors helps to differentiate the different forms of dementia more than overall accuracy in drawing.

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Progressive biparietal atrophy: an atypical presentation of Alzheimer's disease.

Abstract: Objectives-To define the clinical, neuropsychological, and radiological features of bilateral parietal lobe atrophy. Methods-Four patients underwent a comprehensive longitudinal neuropsychological assessment, as well as MRI and HMPAO-SPECT.

Cited by 164 publications

References 33 publications

Residual Perception of Moving Objects: Dissociation of Moving and Static Objects in a Case of Posterior Cortical Atrophy

Residual Perception of Moving Objects: Dissociation of Moving and Static Objects in a Case of Posterior Cortical Atrophy

Visuo-Spatial Imagery Impairment in Posterior Cortical Atrophy: A Cognitive and SPECT Study

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

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