Progressive Chronic Retinal Axonal Loss Following Acute Methanol-induced Optic Neuropathy: Four-Year Prospective Cohort Study

Nurieva, Olga; Diblik, Pavel; Kuthan, Pavel; Sklenka, Petr; Meliska, Martin; Bydzovsky, Jan; Heissigerová, Jarmila; Urban, Pavel; Kotikova, Katerina; Navrátil, Tomáš; Komarc, Martin; Seidl, Zdeněk; Vaněčková, Manuela; Pelclová, Daniela; Zakharov, Sergey

doi:10.1016/j.ajo.2018.04.015

Cited by 40 publications

(35 citation statements)

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“…Abnormal thickness of RNFL on optical coherence tomography as a result of the toxic effect of formic acid on retinal ganglion cells, followed by chronic retinal neurodegeneration, has been previously reported in survivors of acute methanol poisoning [30,55]. DaT SPECT measurements revealed a positive correlation between RNFL thickness and the SBR of the posterior putamen.…”

Section: Discussionmentioning

confidence: 67%

“…Importantly, DaT expression in the posterior putamen was positively associated with RNFL thickness, which is a basic morphological feature of retinal neurodegeneration after acute methanol poisoning [30].…”

Section: Discussionmentioning

confidence: 98%

“…Chronic retinal neurodegeneration with progressive loss of visual functions is observed in up to 24% of methanol-poisoning survivors [30]. Long-term central nervous system (CNS) and visual sequelae of methanol poisoning are associated with significantly decreased quality of life [31].…”

Section: Introductionmentioning

confidence: 99%

“…base deficit, serum methanol, formate, lactate, glucose, and creatinine concentrations), prognostic factors (e.g. arterial blood pH, serum ethanol concentration, poisoning severity score, PSS), and hospital treatment modalities [30,41,42]. To answer these questions, the relationship between 123 I-ioflupane for the striatum, putamen, nucleus caudate SBRs and MRI-based volumes of these brain structures was investigated.…”

Section: Introductionmentioning

confidence: 99%

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Efficiency of 123I-ioflupane SPECT as a marker of basal ganglia damage in acute methanol poisoning: a six-year prospective study

Kotikova

Zogala

Ptáčník

et al. 2020

Preprint

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PurposeInvestigate whether 123I-ioflupane SPECT (DaT SPECT) has the potential as a marker of basal ganglia damage in acute methanol poisoning.MethodsProspective, single-centre, cohort study of patients with confirmed methanol poisoning was conducted. DaT SPECT was performed twice with semi-quantification using DaTQUANTTM and MRI-based volumetry was calculated. Specific binding ratios (SBR) of striatum, caudate nucleus, and putamen were correlated with laboratory parameters of outcome, volumetric data, and retinal nerve fibres layer (RNFL) thickness measurements.ResultsForty-two patients (mean age 46.3±4.2 y; 8 females), including 15 with putamen lesions (Group I) and 27 patients with intact putamen (Group II), underwent DaT SPECT. Volumetry was calculated in 35 of the patients assessed. SBR values for the left putamen correlated with putamen volume (r=0.665; p<0.001). Decreased bilateral SBR values were determined for the striatum and the putamen, but not for the nucleus caudate, in Group I (p<0.05). A strong correlation was observed between the SBR of the posterior putamen and arterial blood pH (r=0.574; p<0.001) and other toxicological parameters of severity of poisoning/outcome including serum lactate, glucose, and creatinine concentrations (p<0.05). The SBR of the posterior putamen positively correlated with the global RNFL thickness (p<0.05). ROC analysis demonstrated a significant discriminatory ability of SBR of the posterior putamen with AUC=0.753 (95%CI 0.604–0.902; p=0.007). The multivariate regression model demonstrated that arterial blood pH, age, and gender were the most significant factors associated with SBR of the posterior putamen.ConclusionDaT SPECT demonstrates significant potential for the diagnosis of methanol-induced basal ganglia damage.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficiency of 123I-ioflupane SPECT as a marker of basal ganglia damage in acute methanol poisoning: a six-year prospective study

Kotikova

Zogala

Ptáčník

et al. 2020

Preprint

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“…However, the nonspecific low‐level sensory deficit may explain our findings without a need to posit specific high‐level cognitive deficit in methanol poisoning. This notion is of importance because BG necrosis and visual sequelae are usually concomitant in methanol poisoning (Hantson et al., ; Zakharov et al., ), and patients after methanol poisoning show a significant retinal nerve fiber layer thickness loss (Nurieva et al., ). Future research combining brain imaging, neuropsychological, and ophthalmological data is needed to delineate the effects of posited high‐level attentional deficits and low‐level sensory deficits on the association between BG volume and cognitive performance in methanol poisoning.…”

Section: Discussionmentioning

confidence: 99%

Methanol Poisoning as an Acute Toxicological Basal Ganglia Lesion Model: Evidence from Brain Volumetry and Cognition

Mana

Vaněčková

Klempíř

et al. 2019

Alcoholism Clin & Exp Res

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Background: Acute methanol poisoning leads to optic neuropathy and necrotic lesions of basal ganglia (BG) and subcortical white matter. Survivors of methanol poisoning exhibit long-term executive and memory deficits. Associations between brain volumetry parameters and cognitive sequelae of methanol poisoning are not known. The aim of our study was to identify long-term associations between the cognitive performance of survivors of methanol poisoning and the volume of the brain structures that are selectively vulnerable to methanol.Methods: We conducted a cross-sectional follow-up study on a sample of patients (n = 33, age 50 AE 14 years, 82% males) who survived acute methanol poisoning during methanol mass poisoning outbreak from September 2012 till January 2013 in the Czech Republic. A battery of neuropsychological tests and brain magnetic resonance imaging were included in the clinical examination protocol. Specific brain structures (putamen, globus pallidus, nucleus caudatus, and frontal white matter) were selected as regions of interest, and their volumes were estimated using the MorphoBox prototype software.Results: In robust multiple regression models, sustained visual attention performance (as assessed by Trail Making Test and Prague Stroop Test) was positively associated with BG structures and frontal white matter volumes (Wald = 9.03 to 85.50, p < 0.01), sensitivity to interference (as assessed by Frontal Battery Assessment) was negatively associated with frontal white matter volume (Wald = 35.44 to 42.25, p < 0.001), and motor performance (as assessed by Finger Tapping Test) was positively associated with globus pallidus and frontal white matter volumes (Wald = 9.66 to 13.29, p < 0.01).Conclusions: Our results demonstrate that smaller volumes of elements of BG-thalamocortical circuitry, namely the BG and frontal white matter, relate to attention and motor performance in methanol poisoning from a long-term perspective. Disruption of those functional circuits may underlie specific cognitive deficits observed in methanol poisoning.

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OCT in Toxic and Nutritional Optic Neuropathies

Grzybowski¹,

Obuchowska²,

Arndt³

2020

OCT and Imaging in Central Nervous System Diseases

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Progressive Chronic Retinal Axonal Loss Following Acute Methanol-induced Optic Neuropathy: Four-Year Prospective Cohort Study

Cited by 40 publications

References 47 publications

Efficiency of 123I-ioflupane SPECT as a marker of basal ganglia damage in acute methanol poisoning: a six-year prospective study

Efficiency of 123I-ioflupane SPECT as a marker of basal ganglia damage in acute methanol poisoning: a six-year prospective study

Methanol Poisoning as an Acute Toxicological Basal Ganglia Lesion Model: Evidence from Brain Volumetry and Cognition

OCT in Toxic and Nutritional Optic Neuropathies

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