The robustness of a reinforced concrete (RC) five-storey building (frame system stiffened by walls) is analysed in the paper. A high ductility class structure is designed in accordance with structural Eurocodes. The response of the structure to eight different scenarios of the ground floor vertical element loss is analysed. Nonlinear Static Analysis (NSA) and Nonlinear Dynamic Analysis (NDA) methods are used for the robustness analysis. Fragility curves of the building are derived from statistical analysis of these results. The values obtained through NSA and NDA, damage limit states of the system, and fragility curves, are compared. The influence of the position of the removed element on robustness of the structure is also analysed.