Progressive nicotine poisoning by multiple transdermal nicotine patches

Abstract

The pharmacokinetic properties of transdermal nicotine patches (TNPs) are different from those of other routes of nicotine administration; further, acute nicotine poisoning by TNPs may present with different clinical features. In the present report, we describe the case of a 23-year-old woman who was admitted to emergency department (ED) at Jeju National University Hospital with loss of consciousness. Five hours before the ED visit, she used multiple TNPs to attempt suicide. Initially, nausea and vomiting occurred, and the symptoms worsened over time. We immediately removed the TNPs, and the application sites were gently washed with sterile water. The patient’s level of consciousness gradually improved, and she fully recovered an altered mental status 5 hours later. Her initial urinary cotinine level was 324 ng/mL. Physicians should be aware that acute nicotine poisoning by TNPs can cause various toxic symptoms.

The Bifunctional Dimer Caffeine-Indan Attenuates α-Synuclein Misfolding, Neurodegeneration and Behavioural Deficits After Chronic Stimulation of Adenosine A1 Receptors

“…Although drugs such as caffeine, nicotine or 1-aminoindan would be clinically relevant for reducing the risk of developing PD, these drugs may be highly toxic at high concentrations [50][51][52]. In addition, there are several side effects of consuming high doses of caffeine or nicotine such as anxiety and nervousness, fast heart rate, heartburn, high blood pressure, cancer and others [53][54][55].…”