Progressive Renal Failure Due to Renal Invasion and Parenchymal Destruction by Adult T-Cell Lymphoma

Srinivasa, Nangali S.; McGovern, Christine; Solez, Kim; Poppema, Sibrandes; Halloran, Philip F.

doi:10.1016/s0272-6386(12)80788-8

Cited by 14 publications

(3 citation statements)

References 11 publications

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“…25,26 Renal failure in the initial phase of the disease in this patient would be attributed to direct infiltration with ATLL in the kidney. 27 Vitreous opacity and pseudohypopyon are 2 clinical features of intraocular lymphoma, which may be either primary or secondary infiltration into the eyeball. Primary intraocular lymphoma presents as vitreous opacity or subretinal infiltrates or their combination, and occurs also in association with primary central nervous system lymphoma.…”

Section: Discussionmentioning

confidence: 99%

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Pathologically Proven Intraocular Infiltration With Adult T-Cell Leukemia/Lymphoma: Two New Cases With Either Vitreous Opacity or Aqueous Hypopyon and Literature Review of 16 Cases

Matsuo

Shimizu

Tanaka

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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This study reported 2 new patients and 16 historical cases with pathologically proven intraocular infiltration with adult T-cell leukemia and lymphoma (ATLL) to know the timing of intraocular infiltration in the disease course. The first case was a 67-year-old woman who developed bilateral vitreous opacity about half a year after the onset of acute type of ATLL that had been unresponsive to chemotherapy. She underwent vitrectomy combined with cataract surgery in both eyes. She had bilateral optic disc atrophy and localized retinal white infiltrates in both eyes. Cytological examination of vitreous aspirates demonstrated medium-sized cells with aberrant flower-like convoluted nuclei, positive for CD3, and thus indicative of T-cells. The second case was a 38-year-old man who was diagnosed acute type of ATLL at the presentation of acute kidney injury. About half a year after initial chemotherapy and allogeneic hematopoietic stem cell transplantation, he developed aqueous hypopyon in the right eye, concurrent with cutaneous and central nervous system relapse. Aqueous tap disclosed class V abnormal cells. The aqueous “pseudohypopyon” resolved in response to another round of chemotherapy with mogamulizumab. In review of 18 patients, intraocular infiltration with ATLL was diagnosed by vitrectomy in 9, aqueous tap in 3, chorioretinal biopsy in 3, and autopsy in 3. The intraocular infiltration developed concurrently with systemic diagnosis of ATLL in 5 patients, but developed later after chemotherapy in 13. In conclusion, intraocular infiltration with ATLL appears rare, and pathological diagnosis by vitrectomy and aqueous tap would help determine therapeutic plan in relapse after chemotherapy.

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Section: Discussionmentioning

confidence: 99%

“… 25 , 26 Renal failure in the initial phase of the disease in this patient would be attributed to direct infiltration with ATLL in the kidney. 27 …”

Section: Discussionmentioning

confidence: 99%

Pathologically Proven Intraocular Infiltration With Adult T-Cell Leukemia/Lymphoma: Two New Cases With Either Vitreous Opacity or Aqueous Hypopyon and Literature Review of 16 Cases

Matsuo

Shimizu

Tanaka

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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“…However, there is no previous reference about serological studies in transplanted patients, although they are generally polytransfused and have been described to have a progressive renal failure associated with ATL (22).…”

mentioning

confidence: 99%

Human T Cell Leukemia Virus Type 1 (HTLV‐1) Antibodies in Healthy Populations and Renal Transplanted Patients in the North‐East of Brazil

Linhares

Eizuru

Andrade

et al. 1994

Microbiology and Immunology

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The seroprevalence of human T cell leukemia virus type 1 (HTLV-1) infection was investigated in Brazilians (570): native inhabitants (298) and descendants from Japanese (272) living in Recife and its neighborhoods-North-east of Brazil. Furthermore, polytransfused renal transplanted patients (54) were also examined for the serological status to this virus. The seropositivity to HTLV-1, screened by enzyme-linked immunosorbent assay (ELISA), was low: 1.34% for the local population and 0.73% for the descendants from Japanese. However, the seropositivity for the renal transplanted patients was found to be 11.1%. This higher value suggests that this retrovirus infection seems to be of importance in this clinical condition.

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Pediatric Renal Neoplasms

et al. 2016

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Progressive Renal Failure Due to Renal Invasion and Parenchymal Destruction by Adult T-Cell Lymphoma

Cited by 14 publications

References 11 publications

Pathologically Proven Intraocular Infiltration With Adult T-Cell Leukemia/Lymphoma: Two New Cases With Either Vitreous Opacity or Aqueous Hypopyon and Literature Review of 16 Cases

Pathologically Proven Intraocular Infiltration With Adult T-Cell Leukemia/Lymphoma: Two New Cases With Either Vitreous Opacity or Aqueous Hypopyon and Literature Review of 16 Cases

Human T Cell Leukemia Virus Type 1 (HTLV‐1) Antibodies in Healthy Populations and Renal Transplanted Patients in the North‐East of Brazil

Pediatric Renal Neoplasms

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