Proinflammatory cytokines during the initial phase of oral mucositis in patients with acute lymphoblastic leukaemia

Morales-Rojas, Thais; Viera, Ninoska; Morón-Medina, Alejandra; Álvarez, C.; Álvarez, Alejandra

doi:10.1111/j.1365-263x.2011.01175.x

Cited by 41 publications

(39 citation statements)

References 9 publications

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“…It has been reported in several human studies that the levels of pro-inflammatory cytokines are increased in the blood and saliva of patients during cancer treatment (14)(15)(16). Other studies using animal models have shown evidence of changes in the serum level and tissue expression of nuclear factor κ-B and the pro-inflammatory cytokines [TNF-α, interleukin (IL)-1β and IL-6) following administration of chemotherapeutic drugs (14,(17)(18)(19).…”

Section: Discussionmentioning

confidence: 97%

Association of tumor necrosis factor-α polymorphism with chemotherapy-induced oral mucositis in patients with esophageal cancer

Sakamoto

Takeda

Kanekiyo

et al. 2016

Molecular and Clinical Oncology

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Section: Discussionmentioning

confidence: 97%

Association of tumor necrosis factor-α polymorphism with chemotherapy-induced oral mucositis in patients with esophageal cancer

Sakamoto

Takeda

Kanekiyo

et al. 2016

Molecular and Clinical Oncology

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“…The reason why may be attributed to the subjects' systemic conditions and the chemotherapeutic agent, which was delivered every 2 days to the ALL children during the induction phase. High doses of methotrexate, which is used as a chemotherapeutic agent to kill leukemic cells, can damage the gingival tissues severely [9]. A previous study conducted by Morales-Rojas et al showed that administration of methotrexate after 96 h increased cytokine levels, including TNF-α [9].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…One possible reason for this is the use of methotrexate, which is one of the most destructive chemotherapeutic agents [9]. Previous studies showed that high doses of methotrexate during the induction phase may lead to an increase of TNF-α levels in the oral cavity, which causes a severe pathological condition of the gingival tissue [9]. TNF-α produced and secreted by antigen-presenting cells, such as monocytes, macrophages, fibroblasts, and dendritic cells, is the central mediator for tissue damage [16].…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy may cause many problems in the oral cavity, such as gingival bleeding, mucositis, and candidiasis [8]. Previous studies show that ALL children who have had chemotherapy treatment have a high level of salivary tumor necrosis factor-alpha (TNF-α) [9]. TNF-α is one of the most important inflammatory mediators that plays a big role in the inflammatory process [10].…”

Section: Introductionmentioning

confidence: 99%

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Effects of a Probiotic Milk Drink on Salivary Tumor Necrosis Factor-Alpha in Children With Acute Lymphoblastic Leukemia in the Induction Phase

Pariaputra

Budiardjo

Suharsini

2018

Asian J Pharm Clin Res

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Objective: The aim of this study was to investigate the effects of the short-term use of a probiotic milk drink on salivary tumor necrosis factor-alpha (TNF-α) in children with acute lymphoblastic leukemia (ALL) during the induction phase of chemotherapy. Methods:A randomized, case-controlled clinical trial was carried out. The samples of the study were collected from 11 children with ALL and 11 healthy children as the control. Both groups received a probiotic milk drink. The probiotic milk drink contained Lactobacillus casei (6.5×10 9 colony forming unit/mL). The subjects were instructed to rinse 5 mL of probiotic milk drink for 30 s over the course of 2 weeks. Unstimulated saliva samples were collected from patients at baseline and 1 and 2 weeks after rinsing with the probiotic milk drink. The levels of TNF-α were determined using a human TNF-α enzyme-linked immunosorbent assay kit. Results:The salivary TNF-α levels in the experimental group decreased but not to a statistically significant degree (p>0.05) when comparing the baseline with weeks 1 and 2 after rinsing. There was a significant decrease of salivary TNF-α levels in the control group (p<0.05) when comparing the baseline with 1 and 2 weeks after rinsing. The concentration of salivary TNF-α in the experimental group was higher than in the control group (p<0.05). Conclusion:This study demonstrates the effect of a short-term intake of a probiotic milk drink on children with ALL during the induction phase of chemotherapy. The results show a reduction of salivary TNF-α after taking the probiotic milk drink after 1 week and 2 weeks, although the results were not statistically significant.

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Correlations between the severity of radiation‐induced oral mucositis and salivary epidermal growth factor as well as inflammatory cytokines in patients with head and neck cancer

Yang

et al. 2023

Head & Neck

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Background This study aimed to investigate correlations of the severity of radiation‐induced oral mucositis (RIOM) with epidermal growth factor (EGF) and inflammatory cytokines in patients with head and neck cancer (HNC). Methods Levels of inflammatory cytokines and EGF in saliva of HNC patients were measured. Correlations of inflammatory cytokines and EGF levels with RIOM severity and pain degree, and their diagnostic values on RIOM severity were determined. Results Elevated IFN‐γ, TNF‐α, IL‐2, and IL‐6 levels, and reduced IL‐4, IL‐10, and EGF levels were found in patients with severe RIOM. IFN‐γ, TNF‐α, IL‐2, and IL‐6 were positively correlated with RIOM severity, while IL‐10, IL‐4, and EGF were negatively correlated with it. All factors were effective in predicting the severity of RIOM. Conclusion IFN‐γ, TNF‐α, IL‐2, and IL‐6 in saliva of patients with HNC are positively correlated with the severity of RIOM, and IL‐4, IL‐10, and EGF were negatively correlated with it.

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Proinflammatory cytokines during the initial phase of oral mucositis in patients with acute lymphoblastic leukaemia

Abstract: It would seem that 96 h is an ideal time for determining the parameters evaluated both in blood and in saliva.

Cited by 41 publications

References 9 publications

Association of tumor necrosis factor-α polymorphism with chemotherapy-induced oral mucositis in patients with esophageal cancer

Association of tumor necrosis factor-α polymorphism with chemotherapy-induced oral mucositis in patients with esophageal cancer

Effects of a Probiotic Milk Drink on Salivary Tumor Necrosis Factor-Alpha in Children With Acute Lymphoblastic Leukemia in the Induction Phase

Correlations between the severity of radiation‐induced oral mucositis and salivary epidermal growth factor as well as inflammatory cytokines in patients with head and neck cancer

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