Projections from serotonin- and substance P-like immunoreactive neurons in the midbrain periaqueductal gray onto the nucleus reticularis gigantocellularis pars α in the rat

Zeng, Shui-Ling; Li, Yun Qing; Rao, Zhi-Ren; Shi, Ji-Wu

doi:10.1016/0304-3940(91)90614-y

Cited by 28 publications

(18 citation statements)

References 15 publications

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“…Part of that projection is from SP-ir neurons (Zeng et al, 1991;Beitz, 1982). It is possible that an LH-to-PAG-to-RVM connection could be responsible for the findings of the present experiments.…”

Section: Discussionmentioning

confidence: 59%

Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla

Holden

Pizzi

2008

Brain Research

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Section: Discussionmentioning

confidence: 59%

Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla

Holden

Pizzi

2008

Brain Research

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“…Other putative transmitter substances including dopamine (DA) (Ochi and Shimizu, 1978;Yoshida et al, 1989;Stratford and Wirtshafter, 1990), nitric oxide (Johnson, 1993;Wotherspoon et al, 1994;Wang et al, 1995), and a variety of neuropeptides (Uhl et al, 1979a,b;Glazer et al, 1981;Johansson et al, 1981;Moss et al, 1981;Zeng et al, 1991;Lechner et al, 1993;Ardvidsson et al, 1994) have also been found in cells within the borders of the DR and various other raphe nuclear groups. Although it is clear that DR neurons contain 5HT and neuroactive substances other than 5HT, there is little detailed information about the neurochemical identity of DR neurons that project to functionally specified neural networks.…”

mentioning

confidence: 95%

Topographic organization and neurochemical identity of dorsal raphe neurons that project to the trigeminal somatosensory pathway in the rat

Kirifides

Simpson

Lin

et al. 2001

J of Comparative Neurology

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The primary goals of this study were to: 1) examine the distribution of neurons within the dorsal raphe (DR) nucleus that project to cortical and subcortical sites along the trigeminal somatosensory pathway in rat; 2) determine the extent to which different regions within this ascending sensory system receive collateral projections from the same DR neuron; and 3) identify the putative transmitters contained within these DR projection neurons. Long-Evans hooded rats received pressure injections of various combinations of retrograde fluorescent tracers; into the whisker-related regions of the primary somatosensory cortex (barrel field cortex [BC]), ventral posterior medial thalamus (VPM), and principal nucleus of the trigeminal complex (PrV). The distribution of retrogradely labeled neurons within the DR was examined by fluorescence microscopy. The major finding was that cortically projecting neurons were located within the midline regions of the rostral portion of the DR, whereas cells projecting to subcortical trigeminal somatosensory structures were distributed bilaterally in the lateral wing regions of the DR as well as in the midline portions of the nucleus. Single neurons that send axon collaterals to multiple cortical and subcortical trigeminal somatosensory targets were observed in the dorsomedian and ventromedian regions of the DR. DR neurons that projected to cortical and subcortical sites contained serotonin but not tyrosine hydroxylase, the marker enzyme for catecholamine transmitters. Taken together, these findings provide further evidence of neurochemical specificity and functional anatomical organization within the DR efferent projection system.

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“…For example, in addition to 5HT, a number of other putative transmitter agents have been identified in cells within the nuclear boundaries of DR. These include gamma amino butyric acid (GABA) / glutamic acid decarboxylase (GAD) (Belin et al, 1979(Belin et al, , 1983Millhorn et al, 1987;Jones et al, 1991;Stamp et al, 1995;Wang et al, 1993), excitatory amino acids (Clements et al, 1987;Descarries et al, 1982;Nicholas et al, 1992), dopamine (Hokfelt et al, 1976;Ochi and Shimizu, 1978;Stratford and Wirtshafter, 1990), multiple neuropeptides (Lechner et al, 1993;Moss et al, 1981;Zeng, 1991;Xu and Hokfelt, 1997), and nitric oxide (NO) (Vincent and Kimura, 1992;Johnson and Ma, 1993;Wotherspoon et al, 1994;Wang et al, 1995;Xu and Hokfelt, 1997). With respect to neurochemical patterning, NOcontaining neurons are of particular interest, because these cells have been observed to cluster in distinct subgroups predominantly within the caudal lateral wing.…”

mentioning

confidence: 96%

Differential expression of nitric oxide in serotonergic projection neurons: Neurochemical identification of dorsal raphe inputs to rodent trigeminal somatosensory targets

Simpson

Waterhouse

Lin

2003

J of Comparative Neurology

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The dorsal raphe (DR) is invested with nitric oxide synthase (NOS)-expressing profiles. To characterize the connections of NO-containing cells and further assess neurochemical relationships maintained by DR, the transmitter identity of the raphe projection to the trigeminal somatosensory system was examined. Rats were injected with retrograde tracer into vibrissae-related target areas or with anterograde tracer into DR. NADPH-diaphorase (NADPHd) histochemistry or NOS-immunostaining was combined with serotonin (5HT)- or serotonin transporter (SERT)-immunolabeling to examine: 1) the presence of NO in 5HT-containing axons from DR; 2) the distribution of NO-containing fibers with respect to other nitrergic profiles in the somatosensory system; and 3) the propensity for individual projection neurons in specific subdivisions of DR to colocalize 5HT and NO. Results confirm that "barrel-like" patches can be identified in several adult trigeminal relay nuclei by NADPHd histochemistry and demonstrate that fibers from DR contain 5HT and NO. Observations include a high percentage of cortical midline projection neurons which contained NADPHd (70-80%) and coexpressed 5HT. In contrast, approximately 40% of retrogradely labeled DR-thalamus cells in the lateral wing demonstrated NADPHd or 5HT expression, but not both in the same neuron. Colocalization of NADPHd and 5HT within individual DR projection neurons indicates that: i) DR is a source of nitrergic input to trigeminal structures, and ii) NO and 5HT may be simultaneously released to influence information-processing within somatosensory targets. Disparities in NADPHd expression between retrogradely labeled DR neuronal subpopulations further suggest functional differences in the impact of NO on cortical and subcortical targets.

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Projections from serotonin- and substance P-like immunoreactive neurons in the midbrain periaqueductal gray onto the nucleus reticularis gigantocellularis pars α in the rat

Cited by 28 publications

References 15 publications

Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla

Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla

Topographic organization and neurochemical identity of dorsal raphe neurons that project to the trigeminal somatosensory pathway in the rat

Differential expression of nitric oxide in serotonergic projection neurons: Neurochemical identification of dorsal raphe inputs to rodent trigeminal somatosensory targets

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