In recent years, education has been paid more and more attention by the society, and the concept of “education without discrimination” has gradually taken root in the hearts of the people. Special education is a form of education for special groups, which embody the fairness of education. Different from the conventional education model, special education often pays more attention to the physical and mental development of special populations, so the curriculum setting method of special education major is also different from the general method. Under this circumstance, how to carry out reasonable curriculum setting has become the core problem that needs to be solved in the reform of special education curriculum. Projective geometry is one of the methods of studying graph transformation, and its core is the principle of projective transformation invariance. Under the guidance of this theory, curriculum reform also presents many invariable characteristics. Based on this, this paper proposed a special education professional curriculum setting method integrating projective geometry, aiming to reform the special education professional curriculum setting strategy by using the invariant theory. In the evaluation of curriculum setting, the article analyzed the effect of new curriculum setting methods on special groups from different dimensions, and preliminarily formulated the initial special education curriculum. It can be concluded from the article in the evaluation grades that with the blessing of the new curriculum setting method, the student's health evaluation reached 2.7, a year-on-year increase of 42.1%. This fully shows that in the course of special education curriculum setting, projective geometry can provide novel ideas and directions for new curriculum setting methods.