Prolactin and Estrogen Binding Sites in the Mammary Gland of the Lactating and Non-Lactating Rat

Bohnet, H. G.; Gómez, Fulgencio; Friesen, Henry G.

doi:10.1210/endo-101-4-1111

Cited by 81 publications

(34 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding that the prolactin rise in plasma during suckling gradually becomes less, agrees with data by Ford and Melampy (1973) and Bohnet et al (1977) who reported a similar tendency in dams which were permanently with their pups. It has been argued that prolactin secretion may be decreasing because pups suck less frequently as they get older, thus reducing the intensity of the suckling stimulus, which is essential for the secretion of the hormone (Neill, 1974).…”

Section: Discussionsupporting

confidence: 93%

“…What we found is that a gradual reduction in the magnitude of the prolactin response occurred when lactation advanced. This is in agreement with data by Ford and Melampy (1973) and Bohnet et al (1977) on dams which were not separated from their young before suckling. In the present report only a modest rise of plasma prolactin was observed at the end of lactation, while Subramanian and Reece (1975) then also observed a small rise.…”

Section: Discussionsupporting

confidence: 93%

“…Meites et al, 1972) and for the induction of increased numbers of prolactin receptors in these glands (cf. Bohnet et al, 1977).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Suckling-Induced Rise of Plasma Prolactin in Lactating Rats: Its Dependance on Stage of Lactation and Litter Size

Mattheij¹,

Gruisen²,

Swarts³

1979

Horm Res

View full text Add to dashboard Cite

The response of plasma prolactin to vigorous suckling was measured in lactating rats which had been isolated for 10-12 h from their offspring. Plasma prolactin was investigated during suckling at various stages of lactation. The results demonstrate that prolactin responds maximally to suckling already in the first days of lactation. In the second half of the lactation period, the prolactin rise in the plasma induced by suckling decreases gradually; this is not due to a reduced suck-intensity of older pups. A relationship is found between the height of the suckling-induced prolactin rise and litter size. The data suggest that during suckling in the first weeks of lactation the pituitary secretes large amounts of prolactin at a constant rate. It is speculated that in the first minutes of suckling, receptors may clear considerable amounts of released prolactin from the circulation.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

The Suckling-Induced Rise of Plasma Prolactin in Lactating Rats: Its Dependance on Stage of Lactation and Litter Size

Mattheij¹,

Gruisen²,

Swarts³

1979

Horm Res

View full text Add to dashboard Cite

show abstract

“…Plasma prolactin levels in mice on day 19 of pregnancy were significantly higher glands was as low as that on day 19 of pregnancy, while that of lactating glands was raised, accord well with the results in rats (Bohnet et al, 1977) and these would mostly be reasonable from the physiological point of view; the synthesis of milk in mammary lobulo-alveoli, for which prolactin is essential, becomes conspicuous by suckling and is reduced by litter removal. On the other hand, there was no difference in prolactin binding of tumors between lactating and nonlactating animals.…”

supporting

confidence: 87%

Prolactin binding in pregnancy-dependent mammary tumors in GR/A mice.

Yanai

Nagasawa

1978

Endocrinol Japon

View full text Add to dashboard Cite

“…In general, receptor levels are high in the mammary gland from virgin animal, decrease during pregnancy, and increase again after or near delivery (121)(122)(123). Prolactin upregulates the number of its receptors, whereas progesterone antagonizes this effect of prolactin (124,125). The number of prolactin receptors on mammary cells from rabbit (122) and mouse (121) in different developmental stages varies in inverse relationship to progesterone levels in serum.…”

Section: Prolactinmentioning

confidence: 99%

Growth Control and Differentiation in Mammary Epithelial Cells

Borellini¹,

Oka²

1989

Environmental Health Perspectives

View full text Add to dashboard Cite

Growth and differentiation of the mammary gland are controlled by various hormones and other environmental factors The role of hormones and growth factors in mammary development is discussed with regard to animal species, physiological stages, and the various experimental systems in vitro. In the female embryo, mammary morphogenesis is induced by the mesenchyme and is hormone independent, whereas androgens cause the partial necrosis of mammary epithelium in the male. Ductal growth during adolescence requires estrogen and prolactin or growth hormone. During pregnancy, progesterone participates in the development of the lobuloaveolar structure of the gland. After parturition, changes in the hormonal environment lead to production and secretion of milk. Proliferation and differentiation of mammary epithelium can be induced in culture systems. Insulin and epidermal growth factor (EGF) stimulate mammary cell proliferation in vitro. EGF is required for the optimal growth of the mammary gland during pregnancy. EGF also appears to play an important role in mammary tumorigenesis in certain mouse strains. Production of milk proteins can be induced in vitro by the synergistic interactions of prolactin, insulin, and glucocorticoids and is inhibited by EGF and progesterone. Complete or partial sequencing of several milk protein genes and comparative analysis have led to identification of a sequence of high homology and conservation in the 5 'flanking region that is likely to be involved in the regulation of milk protein gene expression.

show abstract

Prolactin and Estrogen Binding Sites in the Mammary Gland of the Lactating and Non-Lactating Rat

Cited by 81 publications

References 0 publications

The Suckling-Induced Rise of Plasma Prolactin in Lactating Rats: Its Dependance on Stage of Lactation and Litter Size

The Suckling-Induced Rise of Plasma Prolactin in Lactating Rats: Its Dependance on Stage of Lactation and Litter Size

Prolactin binding in pregnancy-dependent mammary tumors in GR/A mice.

Growth Control and Differentiation in Mammary Epithelial Cells

Contact Info

Product

Resources

About