Prolactin: Does It Have a Role in the Pathogenesis of Psoriasis?

Giasuddin, A. S. M.; El-Sherif, Abdalla I; El-Ojali, S.I.

doi:10.1159/000017981

Cited by 41 publications

(43 citation statements)

References 12 publications

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“…Gorpelioglu et al and Priestley et al did not find any association between serum PRL levels and psoriasis as well as its activity (Gorpelioglu et al, 2008;Priestley et al, 1984). In contrast, a number of investigators have found a significant association between serum PRL and disease activity (Giasuddin et al, 1998;Dilmé-Carreras et al, 2011;Sanch, 2000).…”

Section: Discussionmentioning

confidence: 94%

“…However, there are scarce reports in the literature regarding the significance of PRL in alopecia areata and vitiligo (Gö nül, 2009;. Although many studies found increased serum PRL in patients with psoriasis (Giasuddin et al, 1998;Dilmé-Carreras et al, 2011), there is controversy, however, as to whether raised PRL levels are associated with disease activity. Gorpelioglu et al and Priestley et al did not find any association between serum PRL levels and psoriasis as well as its activity (Gorpelioglu et al, 2008;Priestley et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

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Serum prolactin levels in dermatological diseases: A case–control study

Elsherif

El-Sherif

El-Dibany

2015

Journal of Dermatology & Dermatologic Surgery

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Background: Recent lines of evidence suggest that prolactin (PRL) as a neurohormone may play a role in the activity of psoriasis and some other immune-mediated diseases. Our aim was to evaluate the correlation between serum PRL levels and severity of psoriasis, vitiligo and alopecia areata.Patients and methods: We performed a case-control study on 100 subjects: 75 patients; suffering from psoriasis, vitiligo and alopecia areata; 25 patients in each group and 25 age-and sex-matched healthy controls.Results: Serum prolactin levels were significantly high in all three dermatological diseases in comparison with the control group (P = 0.000). The mean ± SD of the serum prolactin levels was 21.8 ± 11.5 ng/ml, 16.9 ± 6.8 ng/ml, and 16.6 ± 8.0 ng/ml in patients with alopecia areata, psoriasis and vitiligo respectively. Moreover, the serum prolactin levels in patients with alopecia areata and psoriasis were significantly correlated with disease severity (P < 0.05), however no statistically significant correlation was noted between vitiligo severity and serum prolactin levels (P > 0.05).Conclusions: Prolactin may play a role in the pathogenesis of alopecia areata, psoriasis, and vitiligo; and may serve as a biological marker of disease activity in patients with psoriasis and alopecia areata. Ó 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Serum prolactin levels in dermatological diseases: A case–control study

Elsherif

El-Sherif

El-Dibany

2015

Journal of Dermatology & Dermatologic Surgery

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“…Earlier small studies with 12 PV patients and 7 with PsA showed elevated serum PRL levels in PV (ref. 29 ) but not in PsA (ref. 30 ).…”

Section: Discussionmentioning

confidence: 97%

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

Hušáková¹,

Lippert²,

Štolfa³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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a Background and Aims. Psoriasis vulgaris (PV) is complicated in up to 40% patients by the inflammatory joint disease psoriatic arthritis (PsA). Neither the aetiology of the arthritis nor specific laboratory markers for its disease activity have been clearly elucidated. Prolactin (PRL) acts as a cytokine with immunomodulatory functions and plays a role in skin and joint biology. The results on PRL however as a marker are unclear. The aim of this study was to confirm whether serum PRL levels reflect systemic complications of PV, like inflammatory joint disease and/or can serve as a marker of disease activity in both cases. Methods. A total of 70 patients with PV without arthritis and 40 patients suffering from PsA were included. In all patients, we determined skin disease activity according to the PASI index and in PsA, active disease assessed as swollen or tender joints. The control group included 27 age and sex matched healthy individuals. The concentration of PRL in the serum was measured by immunoradiometric assays. Results. The PRL serum levels were significantly increased in PsA patients (299.2±28.29 mIU/L) compared to PV only patients (201.4.2±11.72 mIU/L), P = 0.0003 and healthy individuals (198.2±15.31 mIU/L), P = 0.007. The serum PRL levels in PsA with active disease 336.8±42.50 (mIU/L) were higher than in PV and controls, P < 0.0001 and P = 0.002 respectively. In PV only patients, there was no correlation between PASI and PRL levels. Conclusion. Our results showed that PRL serum levels are a marker of active arthritis in PsA and reflects systemic complication rather than local skin activity.

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“…In another, independent patient group we have confirmed similar plasma PRL levels in 22 active RA patients compared to 16 healthy controls (44). In contrast, higher PRL levels have been reported in patients with psoriasis compared to control disease and healthy controls (45), and it has been suggested that PRL may play a role in the pathogenesis of psoriasis (46). Collectively, most of the evidence suggests that plasma PRL levels are on average not elevated in RA, while more validation is needed in conditions like psoriasis.…”

Section: The Role Of Prl In Ra and Psamentioning

confidence: 98%

Insight into the Endocrine System and the Immune System: A Review of the Inflammatory Role of Prolactin in Rheumatoid Arthritis and Psoriatic Arthritis

et al. 2017

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Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects females three times more frequently than males. A potential role for hormones, such as prolactin (PRL), may in part explain this phenomenon. The risk of developing RA is increased in women who are lactating after the first pregnancy, which might be related to breastfeeding and the release of PRL. Other studies found a protective effect of PRL on RA development. Some studies have reported that hyperprolactinemia is more common in RA and serum PRL levels are correlated with several disease parameters, although others could not confirm these findings. Overall the plasma PRL levels are on average not elevated in RA. Previously, a small number of open-label clinical trials using bromocriptine, which indirectly decreases PRL levels, were performed in RA patients and showed clinical benefit, although others found the opposite effect. Locally produced PRL at the site of inflammation may have a crucial role in RA as well, as it has been shown that PRL can be produced by synovial macrophages. Locally produced PRL has both pro-inflammatory and anti-inflammatory effects in arthritis. Psoriatic arthritis (PsA) is also an autoinflammatory disease, in which the prolactin receptor is also expressed in macrophages. The aim of this review is to provide an overview of the potential role of PRL signaling in inflammatory joint diseases (RA and PsA) and its potential as a therapeutic target.

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Prolactin: Does It Have a Role in the Pathogenesis of Psoriasis?

Cited by 41 publications

References 12 publications

Serum prolactin levels in dermatological diseases: A case–control study

Serum prolactin levels in dermatological diseases: A case–control study

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

Insight into the Endocrine System and the Immune System: A Review of the Inflammatory Role of Prolactin in Rheumatoid Arthritis and Psoriatic Arthritis

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