Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele

Özcan, Ömer; Malkoç, Ercan; Coşar, Alpaslan; İpçioğlu, Osman Metin; Gültepe, Mustafa; Müftüoğlu, Tuba; Hira, Serdar; Ateş, Ferhat

doi:10.3109/00365513.2012.743676

Cited by 3 publications

(3 citation statements)

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“…As can be shown in Table 1, the current study demonstrates that a substantial correlation exists between serum prolidase activity and the development of varicose veins in pregnant women. It is possible that prolidase, which is associated with oxidative stress, plays an important role in the pathophysiology of varicose vein development (26).…”

Section: Discussionmentioning

confidence: 99%

Effect of prolidase on the development of varicose veins in pregnant women

Al-Bahrani¹

2023

Biomedicine

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Introduction and Aim: Varicose veins are more common during pregnancy and, if left untreated, can cause venous insufficiency and edema in the legs. Women have venous insufficiency both before and after pregnancy. According to research, the cytosolic metalloproteinase prolidase regulates the breakdown of collagen and other proteins in the extracellular matrix. Prolidase deficiency, which impairs the enzyme's normal function, has severe clinical manifestations. The objective of this study is to discover how the enzyme prolidase influences the development of varicose veins in pregnant women. Materials and Methods: This study included approximately 70 women aged 25-45 years who were pregnant in their third trimester. The participants were assigned to two groups based on diagnosis of having varicose veins (n=40) and those without (n=30). Quantitative measurements of serum progesterone and prolidase concentrations were made. Data collected was subjected to statistical analysis. Results: Varicose veins were prevalent in 57.14% of the pregnant women, the severity of which increased with age. The mean blood concentrations of progesterone and prolidase levels were higher in pregnant women with varicose veins in comparison to controls. Conclusion: Chronic venous insufficiency and mild varicose veins are more common in pregnant women aged 40 years and above. An increased level of progesterone and prolidase enzyme in serum was seen to be associated with chronic varicose insufficiency in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Effect of prolidase on the development of varicose veins in pregnant women

Al-Bahrani¹

2023

Biomedicine

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“…This enzyme enables proline to contribute to collagen production again. This enzyme is accepted as the rate-limiting enzyme in collagen metabolism, as 90% of proline used in collagen production is provided from the proline included in the cycle [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Prolidase Enzyme Activity in Conjunctiva and Pterygium Tissues

et al. 2015

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BackgroundThe aim of this study was to determine prolidase activity in conjunctival tissue and its relationship with pterygium.Material/MethodsProlidase activity was measured in 23 pterygium and 25 healthy conjunctival tissues and the 2 groups were compared.ResultsProlidase enzyme activity could not be measured in either the healthy conjunctival or in pterygium tissues. The mean serum prolidase levels of the control and pterygium groups were 967.46±353.64 and 858.29±301.83, respectively. Statistically, there was no significant difference between the groups with regard to serum prolidase levels (p>0.05).ConclusionsIn conclusion, absence of prolidase activity in pterygium tissue indicates that there is no collagen turnover in this tissue. We may explain this finding with the elastin-rich structure of the conjunctiva.

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“…It was pointed in various studies that the increase in serum prolidase activity is effective in the oxidant/antioxidant capacity in various diseases and may cause them by this way 7−10 . Ozan et al 11 indicated that prolidase enzyme activity is increased in patients with varicosele.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress And Prolidase Enzyme Activity In The Pathogenesis Of Primary Varicose Veins

et al. 2017

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Objectives Vascular endothelial dysfunction leads to the emerging of free oxygen radicals, deficiency of antioxidant system, forming of oxidative stress, inflammatory processes and release of proinflammatory cytokines. These things play big role in the development of primary varicose veins. Prolidase has been reported as an indicator of oxidative stress in diabetes, diabetic neuropathy, non-ulcerous dyspepsia, osteoporosis, polycystic over syndrome and many other diseases. The aim of this study is to evaluate the oxidative stress at venous insufficiency and to provide preliminary knowledge about the role of prolidase enzyme in varicose vein formation. Methods Ninety patients aged between 22 and 80 (47.35 ± 17.69) were included in the study and divided into 3 groups. Group1(n:30)(Serum control group): Patients without venous insufficiency. Group 2(n:30)(Tissue control group(healthy vein group): Patients underwent coronary artery bypass surgery (the remaining portion of great saphenous vein used as coronary artery bypass graft used as normal tissue) . Group 3(n:30)(Varicose vein group): Patients underwent varicose vein surgery (varicose vein and serum of these patients were used for study). Total Oxidant Status (TOS), Total Antioxidant Status (TAS), Oxidative Stress Index (OSI) and Prolidase enzyme levels were detected in tissue and serum samples. Results No significant changes were detected between three groups' serum samples in oxidative stress parameters and in the prolidase enzyme activity. The tissue TOS and OSI were higher in varicose vein group according to normal vein group and this was found statistically significant. And TAC levels in varicose vein group were significantly lower than normal vein group. Prolidase enzyme activity in varicose vein group was found higher according to normal vein group. Conclusion Oxidative stress plays a role at the development of primary varicose veins at biochemical level. Prolidase enzyme related with oxidative stress may play an important role in the pathogenesis of primary varicose veins.

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Prolidase enzyme activity in varicose venous walls related to sperm count in patients with varicocele

Abstract: Varicose venous wall prolidase enzyme activity could be an important factor in progression of azoospermia and infertility in patients with varicocele.

Cited by 3 publications

References 35 publications

Effect of prolidase on the development of varicose veins in pregnant women

Effect of prolidase on the development of varicose veins in pregnant women

Prolidase Enzyme Activity in Conjunctiva and Pterygium Tissues

Oxidative Stress And Prolidase Enzyme Activity In The Pathogenesis Of Primary Varicose Veins

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