Proliferative verrucous leukoplakia, squamous cell carcinoma and axillary metastasis

Gouvêa, Adriele Ferreira; Moreira, Adriana Elisa Brasil; Reis, Rodrigo R. Dias dos; Almeida, Oslei Paes de; Lopes, Márcio Ajudarte

doi:10.4317/medoral.15.e704

Cited by 13 publications

(16 citation statements)

References 14 publications

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“…The epidemiological data of our patients (Table ) was in agreement with published guidelines . Nine patients (42.9%) developed carcinomas, which were present in 14 PVL samples (Table ).…”

Section: Discussionsupporting

confidence: 88%

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High incidence of DNA ploidy abnormalities and increased Mcm2 expression may predict malignant change in oral proliferative verrucous leukoplakia

et al. 2013

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“…The epidemiological data of our patients (Table ) was in agreement with published guidelines . Nine patients (42.9%) developed carcinomas, which were present in 14 PVL samples (Table ).…”

Section: Discussionsupporting

confidence: 88%

“…It has an unknown aetiology, and the diagnosis must be made retrospectively on the basis of the clinical and histopathological features. The lesions develop at multiple sites of the oral mucosa, show resistance to all types of treatment, and have high rates of recurrence and malignant transformation …”

Section: Introductionmentioning

confidence: 99%

High incidence of DNA ploidy abnormalities and increased Mcm2 expression may predict malignant change in oral proliferative verrucous leukoplakia

et al. 2013

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“…Twenty-five articles met inclusion criteria (13 retrospective series; 12 case reports). 1,3 -27 One additional patient was identified within the gray literature for a total of 329 patients with PVL.…”

Section: Resultsmentioning

confidence: 99%

Optimal Management of Proliferative Verrucous Leukoplakia

Abadie¹,

Partington

Fowler

et al. 2015

Otolaryngol.--head neck surg.

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“…Case series published over the years agree that the OVC tends to grow locally but not to cause ganglionar spread ( 22 , 23 ). However, there are few published papers that refer of distant metastases as in the orbit ( 24 ) and axillary lymph nodes ( 25 ). Thereby, cervical dissection should not be indicated in all cases of OVC.…”

Section: Discussionmentioning

confidence: 99%

Verrucous carcinoma of the oral mucosa: An epidemiological and follow-up study of patients treated with surgery in 5 last years

Candau-Alvarez¹,

Ferrer²,

Alamillos-Granados³

et al. 2014

Med Oral

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Introduction: Oral Verrucous Carcinoma (OVC) is described apart of the Squamous Cell Carcinoma (SCC) due to its specific properties. The objective of our study is to show our series of cases of OVC and to compare with the SCC in terms of clinical manifestations, epidemiology, histopathology, treatment and follow-up. Material and Methods: This is a retrospective study of all the OVC treated in our department between January-2007 and December-2011. The analyzed variables were sex, age, localization in the oral cavity, histopathology, number of biopsies needed to diagnose OVC, TNM classification, treatment and recurrences during follow-up. Results: Our sample was composed by n=14 patients, 57% female, with a mean age of 69.14 years. The most common localization was buccal mucosa (n=5). Seven patients were diagnosed of OVC with the first biopsy. TNM classification was: pT1: 7 patients, pT2: 3 patients, pT3: 3 patients, pT4: 1 patient. No cervical metastases were observed either in cervical neck dissection or during the follow-up of the patients. The treatment was surgery with clinical resection margins up to 1 cm in all cases, followed by radiotherapy in selected cases. Only n=1 patient (7.69%) presented a recurrence after 34 months of follow-up. The overall survival rate was 92.85%. Conclusions: In our population, OVC represents the 6.16% of all oral cavity and oropharynx cancer, and is more frequent in female patients above 70 years old. It uses to rise over a previous lesion, and usually affects the buccal mucosa. In patients with high suspicious lesions, more than one biopsy may be needed to diagnose OVC. No patient showed cervical dissemination. In our experience, treatment based on local resection, without cervical neck dissection, could be a good option for these patients. Key words:Verrucous carcinoma, squamous cell carcinoma, oral cancer, oral cavity, epidemiology, follow-up.

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Proliferative verrucous leukoplakia, squamous cell carcinoma and axillary metastasis

Cited by 13 publications

References 14 publications

High incidence of DNA ploidy abnormalities and increased Mcm2 expression may predict malignant change in oral proliferative verrucous leukoplakia

High incidence of DNA ploidy abnormalities and increased Mcm2 expression may predict malignant change in oral proliferative verrucous leukoplakia

Optimal Management of Proliferative Verrucous Leukoplakia

Verrucous carcinoma of the oral mucosa: An epidemiological and follow-up study of patients treated with surgery in 5 last years

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