Prolonged and unprolonged complex febrile seizures differently affect frontal theta brain activity

Thébault-Dagher, Fanny; Deguire, Florence; Knoth, Inga Sophia; Lafontaine, Marc Philippe; Barlaam, Fanny; Côté, Valérie; Agbogba, Kristian; Lippé, Sarah

doi:10.1016/j.eplepsyres.2019.106217

Cited by 5 publications

(4 citation statements)

References 80 publications

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“…Non-phase locked activity is relevant to event related responses since it is induced by the stimulus, although eliminated in a traditional ERPs analysis by the signal averaging procedure involved in that method ( Musacchia et al, 2015 ). Most robust response in terms of brain oscillations associated with repetition and change detection has been reported in the theta oscillations ( Isler et al, 2012 ; Musacchia et al, 2015 ; Thébault-Dagher et al, 2020 ; López-Arango et al, 2021 ); however, decreases in power associated with repetition and increases in power associated with change detection in beta, alpha and gamma oscillations have also been described in neurotypical newborns ( Isler et al, 2012 ) and in infants ( Ortiz-Mantilla et al, 2013 , 2016 ) and in preterm neonates ( Mahmoudzadeh et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of brain overgrowth on sensorial learning processing during the first year of life

López-Arango

Deguire

Agbogba

et al. 2022

Front. Hum. Neurosci.

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Macrocephaly is present in about 2–5% of the general population. It can be found as an isolated benign trait or as part of a syndromic condition. Brain overgrowth has been associated with neurodevelopmental disorders such as autism during the first year of life, however, evidence remains inconclusive. Furthermore, most of the studies have involved pathological or high-risk populations, but little is known about the effects of brain overgrowth on neurodevelopment in otherwise neurotypical infants. We investigated the impact of brain overgrowth on basic perceptual learning processes (repetition effects and change detection response) during the first year of life. We recorded high density electroencephalograms (EEG) in 116 full-term healthy infants aged between 3 and 11 months, 35 macrocephalic (14 girls) and 81 normocephalic (39 girls) classified according to the WHO head circumference norms. We used an adapted oddball paradigm, time-frequency analyses, and auditory event-related brain potentials (ERPs) to investigate differences between groups. We show that brain overgrowth has a significant impact on repetition effects and change detection response in the 10–20 Hz frequency band, and in N450 latency, suggesting that these correlates of sensorial learning processes are sensitive to brain overgrowth during the first year of life.

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Section: Introductionmentioning

confidence: 99%

Impact of brain overgrowth on sensorial learning processing during the first year of life

López-Arango

Deguire

Agbogba

et al. 2022

Front. Hum. Neurosci.

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“…Febrile seizures, which are induced by hyperpyrexia, constitute a common nervous disease that mainly occurs in children ( Graves et al, 2012 ). They are classified into two types, according to the clinical characteristics: simple FS (duration of < 15 min) and complex FS ( Subcommittee on Febrile Seizures and American Academy of Pediatrics, 2011 ; Thébault-Dagher et al, 2020 ). Although epidemiological studies have shown that simple FS have almost no significant influence on brain structure and cognition ( Renda et al, 2020 ), a recent study confirmed that simple FS cause subtle changes in synaptic functions ( Postnikova et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Xenon inhalation attenuates neuronal injury and prevents epilepsy in febrile seizure Sprague-Dawley pups

Cheng,

Zhai,

Yuan

et al. 2023

Front. Cell. Neurosci.

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BackgroundFebrile seizures (FS) usually occur in childhood and may cause irreversible neuronal damage, cognitive functional defects, and an increase in the risk of epilepsy later in life. Anti-epileptic drugs (AEDs), currently used to treat FS in children, can relieve seizures. However, their effects in preventing the risk of developing epilepsy in later life are unsatisfactory. Moreover, AEDs may damage child brain development. Here, we evaluated the efficiency of xenon in treating prolonged FS (PFS) and preventing epilepsy in Sprague-Dawley pups.MethodsProlonged FS was induced by hyperthermic treatment. After 90 min of PFS, the pups in the xenon treatment group were immediately treated with 70% xenon/21% oxygen/9% nitrogen for 60 min. The levels of glutamate, mitochondrial oxidative stress, mitophagy, and neuronal injury, seizures, learning, and memory functions were measured at specific time points.ResultsNeonatal period PFS led to spontaneous seizure, learning and memory dysfunction, accompanied by increased levels of glutamate, mitochondrial oxidative stress, mitophagy, and neuronal injury. Xenon treatment alleviated the changes caused by PFS and reduced the risk of PFS developing into epilepsy later.ConclusionOur results suggest that xenon inhalation could be a potential therapeutic strategy to attenuate neuronal injury and prevent epilepsy in patients with FS.

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“…It is possible that infants with CFS do not present sequelae within this timeframe or are still too young for any to be detected by objective measures, as cognitive capacities have yet to be differentiated at that point. Of note, an altered functional signal has been found in young children with CFS, suggesting that the mechanisms underlying cognitive sequalae are already at play [41]. As such, school-age participants with CFS demonstrate weaknesses in executive functioning, and to a lesser extent, learning and memory abilities, which worsen as a function of seizure duration, despite normal global intelligence.…”

Section: Discussionmentioning

confidence: 99%

Cognitive and behavioural development in children presenting with complex febrile seizures: at onset and school age

Sheppard¹,

Lalancette²,

Thébault-Dagher³

et al. 2021

Epileptic Disorders

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Objective. Our goal was to assess development, cognition and behaviour following an initial complex febrile seizure (FS), at onset and school age, in the context of known risk factors for cognitive development. Methods. Two cohorts were recruited. Thirty-five infants with an initial complex FS were assessed within the first year post-seizure and compared to 30 controls (simple FS) based on measures of cognitive, motor and language development, behaviour and emotions. Additionally, 19 school-age children with previous complex FS (11 multiple, eight prolonged) were assessed and compared to 19 controls (simple FS) based on measures of intelligence, learning/memory, executive functioning, behaviour and emotions. Results. Within the first year post-onset, infants with complex FS did not significantly differ from controls based on developmental measures. Seizure duration and age at seizure onset did not impact developmental outcome. School-age children with complex FS showed unaltered global intelligence, but lower executive functioning, compared to controls. Children with prolonged FS also showed evidence of a lower level of learning and memory abilities. Neuropsychological scores correlated with seizure duration. Children with complex FS showed more attentional problems and anxious/depressed symptomatology at onset and school age, and more hyperactivity at school age. Significance. Infants with complex FS seemed to show normal development within the first year post-seizure onset. However, challenges in executive functioning, learning and memory at school age were found in children with a history of FS. Hence, at school age, cognitive challenges cannot be excluded based on undifferentiated early cognitive development, and may occur even in the absence of the most severe form of FS (i.e., FSE). Beyond the limits of this study (i.e., small sample size, use of parental questionnaires for emotional/behavioural outcome, absence of focal cases in the school-age cohort), our results suggest that a follow-up is necessary beyond the early preschool years in order to understand the long-term outcome.

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Prolonged and unprolonged complex febrile seizures differently affect frontal theta brain activity

Cited by 5 publications

References 80 publications

Impact of brain overgrowth on sensorial learning processing during the first year of life

Impact of brain overgrowth on sensorial learning processing during the first year of life

Xenon inhalation attenuates neuronal injury and prevents epilepsy in febrile seizure Sprague-Dawley pups

Cognitive and behavioural development in children presenting with complex febrile seizures: at onset and school age

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