Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells

Yawata, Atsushi; Adachi, Masaaki; Okuda, Hiroyuki; Naishiro, Yasuyoshi; Takamura, Takenori; Hareyama, Masato; Takayama, Shinichi; Reed, John C.; Imai, Kohzoh

doi:10.1038/sj.onc.1201792

Cited by 144 publications

(97 citation statements)

References 12 publications

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“…Together with our previous data showing that antiapoptotic activity of BAG-1 promotes peritoneal dissemination of gastric cancer cells (Yawata et al, 1998), the ability of BAG-1 to promote cell migration suggest an important role for this protein in tumor invasion and metastasis. Clinical-correlative studies are presently underway to explore the association between high levels of BAG-1 protein and metastatic spread of gastric cancers.…”

Section: Discussionsupporting

confidence: 81%

“…In our studies, the well-di erentiated gastric cancer cell line MKN74 expresses BAG-1 at a relatively low level compared with the poorly differentiated gastric cancer line MKN45 (Yawata et al, 1998). To explore the biological functions of BAG-1 in gastric cancer cells, a bag-1 cDNA encoding the murine BAG-1 protein (Takayama et al, 1995) was stably introduced into MKN74 cells.…”

Section: Resultsmentioning

confidence: 99%

“…Murine melanoma B16-BL6 transfectant cells overexpressing BAG-1 have been shown to be resistant to apoptosis and exhibited enhanced pulmonary metastasis (Takaoka et al, 1997). Overexpression of BAG-1 in a human gastric cancer cell line led to prolonged cell survival against apoptosis induced by cell detachment`anoikis' and increased peritoneal dissemination in animals, which were attributed to its ability to promote cell survival in a detached state (Yawata et al, 1998). BAG-1 also binds to the receptor for hepatocyte growth factor (HGF) and platelet-derived growth factor (PDGF), resulting in enhancement of protection from apoptosis caused by deprivation of these growth factors (Bardelli et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

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BAG-1 accelerates cell motility of human gastric cancer cells

et al. 1999

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Section: Discussionsupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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BAG-1 accelerates cell motility of human gastric cancer cells

et al. 1999

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“…Heat shock proteins are also required for cell survival and direct activation of these functions may also be important. Suppression of apoptosis might contribute to the ability of BAG-1 to promote metastatic spread (Takaoka et al, 1997;Yawata et al, 1998). Alternatively, increased metastasis may be mediated by enhanced cell motility (Yawata et al, 1998).…”

Section: Bag-1 Functionmentioning

confidence: 99%

“…BAG-1 enhances metastasis in experimental models (Takaoka et al, 1997;Yawata et al, 1998) and Shindoh et al (2000) demonstrated that BAG-1 was expressed in 89% of primary tumours with nodal metastasis compared to 38% of tumours without. BAG-1 expression levels were determined by densitometry and although this alleviates the subjectivity of scoring BAG-1 labelling intensity to some extent it does not give information on whether the immunoreactivity is nuclear or cytoplasmic.…”

Section: Bag-1 and Other Malignanciesmentioning

confidence: 99%

BAG-1 expression and function in human cancer

et al. 2002

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BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function.

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Anticancer activity of novel 3‐(furan‐2‐yl)pyrazolyl and 3‐(thiophen‐2‐yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies

Helmy

Sroor

Mahrous

et al. 2021

Archiv der Pharmazie

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Twelve novel chalcone derivatives were prepared using the Claisen–Schmidt condensation reaction. The reaction of 4‐acetyl‐5‐furan/thiophene‐pyrazole derivatives 5 with the corresponding aldehydes 6 afforded the targeted chalcone derivatives 7a–l in good yields. The newly synthesized chalcones were fully characterized by spectrometric and elemental analyses. The in vitro anticancer activities of the novel compounds 7a–l were evaluated against four human cancer cell lines: HepG2 (human hepatocellular carcinoma), MCF7 (human Caucasian breast adenocarcinoma), A549 (lung carcinoma), and BJ1 (normal skin fibroblasts). Compound 7g emerged as the most promising compound, with IC50 = 27.7 µg/ml against A549 cells compared to the reference drug doxorubicin (IC50 = 28.3 µg/ml), and IC50 = 26.6 µg/ml against HepG2 cells compared to the reference drug doxorubicin (IC50 = 21.6 µg/ml). The gene expression and DNA damage values and the DNA fragmentation percentages for compound 7g were determined on the lung and liver cell lines. The expression levels of the AMY2A and FOXG1 genes increased significantly (p < 0.01) in the negative samples of lung cancer cells compared with treated cells. Also, the expression values of the PKM and PSPH genes improved significantly (p < 0.01) in the negative samples compared with treated samples of liver cancer cells. The DNA damage values increased significantly (p < 0.01) in treated lung cell line samples (7g) and the positive control. The results showed a significant decrease (p < 0.05) in DNA damage values in the negative samples of liver cancer cells compared to those treated with 7g. However, the DNA fragmentation values increased significantly (p < 0.01) in the treated lung and liver cell line samples compared with the negative control.

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Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells

Cited by 144 publications

References 12 publications

BAG-1 accelerates cell motility of human gastric cancer cells

BAG-1 accelerates cell motility of human gastric cancer cells

BAG-1 expression and function in human cancer

Anticancer activity of novel 3‐(furan‐2‐yl)pyrazolyl and 3‐(thiophen‐2‐yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies

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