Prolonged sitting time links to subclinical atherosclerosis

Abstract

Background: This study investigates the association between daily sitting time and subclinical atherosclerosis by using coronary computed tomography angiography (CCTA). Methods: The study enrolled 203 subjects (age 57.6 ± 8.8 years) who underwent CCTA at annual medical checkups. Sitting time was categorized as < 5 hours/day (short), 5 to 9 hours/day (moderate) and ≥10 hours/d (long). We analyzed the coronary calcium score, plaque characteristics, and severity of coronary artery stenosis, including the segment involvement score (SIS) and segment stenosis score (SSS). Results: Subjects with longer sitting times tended to be male gender and have lower levels of high-density lipoprotein cholesterol (p for trend < 0.05). In addition, those with longer sitting time had higher SIS (1.2 ± 1.5 vs. 1.6 ± 2.1 vs. 2.3 ± 2.0 for short, moderate, and long sitting time, respectively) (p for trend = 0.015) and SSS (1.4 ± 2.0 vs. 1.9 ± 2.7 vs. 2.7 ± 2.6) (p for trend = 0.015), suggesting longer sitting time-correlated with the severity of coronary atherosclerosis. When considering the coronary plaque patterns, subjects with shorter sitting time (<5 hours/d) tended to have more calcified plaque and subjects with longer sitting time (≥10 hours/d) had more mixed plaque (p for trend = 0.018). After adjusting for age, gender, comorbidities, body mass index, and lipid profiles, increased sitting time was independently associated with the presence of mixed plaque, suggesting longer sitting time may be associated with higher risk of the formation of vulnerable plaque. Conclusion: Longer sitting time was linked to the severity of subclinical atherosclerosis and the presence of high-risk vulnerable plaque in the general population.

The impact of hyperlipidemia and carotid atherosclerosis

“…4 This is of great importance because atherosclerosis is highly associated with bad prognosis such as ischemic stroke and coronary artery disease. [5][6][7] Nevertheless, we should interpret the statistics with more caution and take possible bias into consideration, to avoid the risk of misinterpretation, which have been well-known in the literature. 8,9 We hope to learn more from the authors with a positive response.…”

To Do One and To Get More: Part II. Diabetes and metabolic dysfunction-associated fatty liver diseases

“…Diabetes mellitus (DM), a complex chronic systemic inflammatory disease, is a heavy socio-economic burden resulting from the severe morbidity and mortality imposed by direct DM-associated diseases and indirect DM accompanied with disorders, 1 secondary to the micro- and macrovascular damage and dysfunction, resulting in hypertension, 2 ischemic stroke, 3 ophthalmic problems (macular edema 4,5 and neovascularization 6 ), kidney-associated diseases 7 and their related complications, 8 sexual dysfunction, 9 neurological disorders, 10 peripheral neuropathy, 11 diabetic foot or other chronic subcutaneous ulcer problems, 12 metabolic associated fatty liver disease (MAFLD, also called as metabolic dysfunction-associated fatty liver disease [FLD], nonalcoholic FLD [NAFLD] or metabolic associated steatohepatitis [MASH]), 13 atherosclerosis 14 and atherosclerotic cardiovascular disease, 15 osteoporosis, 16,17 and fracture. 18 DM is also complicated by acute life-threatening diseases, 19 such as hyperglycemia (hyperglycemia hyperosmolar nonketotic coma and diabetic ketoacidosis) or hypoglycemia (syncope and sudden death) 20,21 as well as exacerbation of many chronic illnesses-related mortality (cancer as an example).…”

Winners of the 2022 honor awards for excellence at the annual meeting of the Chinese Medical Association-Taipei: Part III

“…This editorial represents the third part of our awards coverage, highlighting two exceptional studies. 1,2 We’re honored to introduce the winners and provide a summary of their remarkable findings. Their contributions significantly impact global health advancement and provide invaluable references for healthcare professionals, aiding them in treating and managing patients in similar clinical scenarios.…”

“…First, we are pleased to dedicate this editorial to the research, “Prolonged sitting time links to subclinical atherosclerosis,” by Lim et al, 1 recognized with our Outstanding Research Award. This pivotal study presents convincing findings on the impact of extended sedentary behavior on coronary atherosclerosis.…”

“…This pivotal study presents convincing findings on the impact of extended sedentary behavior on coronary atherosclerosis. 1 Lim et al 1 analyzed the effects of extended sitting time on cardiovascular health. The study population comprised 203 subjects (age 57.6 ± 8.8 years, 149 male and 54 female) and divided into three groups based on their sitting time.…”