Promising Nanostructured Materials against Enveloped Virus

Toledo, Gabriel G. De; Toledo, Víctor H.; Lanfredi, Alexandre J. C.; Escote, M. T.; Champi, A.; Silva, Maria Cristina C. Da; Nantes, Iseli L.

doi:10.1590/0001-3765202020200718

Cited by 17 publications

(8 citation statements)

References 117 publications

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“…The virucidal activity of titanium oxide nanoparticles (TiO

NPs) is essentially correlated with the ability to generate ROS under UV irradiation, thus causing oxidative damages to biomolecules. The same ability was also shown by other semiconductor materials, such as Fe

and ZnO, pointing out the high potential for virus inactivation and the potential use for production of textiles and objects with self-disinfecting properties [ 130 ]. Moreover, TiO

NPs possess direct antiviral activity and may also have a role in viral clearance by stimulating immune mechanisms.…”

Section: Nanomaterials For Covid-19 Prevention and Treatmentmentioning

confidence: 66%

Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived Drugs

et al. 2022

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The last few years have increasingly emphasized the need to develop new active antiviral products obtained from artificial synthesis processes using nanomaterials, but also derived from natural matrices. At the same time, advanced computational approaches have found themselves fundamental in the repurposing of active therapeutics or for reducing the very long developing phases of new drugs discovery, which represents a real limitation, especially in the case of pandemics. The first part of the review is focused on the most innovative nanomaterials promising both in the field of therapeutic agents, as well as measures to control virus spread (i.e., innovative antiviral textiles). The second part of the review aims to show how computer-aided technologies can allow us to identify, in a rapid and therefore constantly updated way, plant-derived molecules (i.e., those included in terpenoids) potentially able to efficiently interact with SARS-CoV-2 cell penetration pathways.

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“…The virucidal activity of titanium oxide nanoparticles (TiO

and ZnO, pointing out the high potential for virus inactivation and the potential use for production of textiles and objects with self-disinfecting properties [ 130 ]. Moreover, TiO

NPs possess direct antiviral activity and may also have a role in viral clearance by stimulating immune mechanisms.…”

Section: Nanomaterials For Covid-19 Prevention and Treatmentmentioning

confidence: 66%

Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived Drugs

et al. 2022

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“…Furthermore, the results praise the MnMoO 4 polymorphs as outstanding candidates for antiviral and antibacterial purposes such as masks, cloths, gloves, other health devices, inks, and other surface protection. It is important to highlight that this kind of property emerges as vital to current human society due to different viruses and bacteria that can spread worldwide fast; in this context, the SARs-CoV-2 (COVID-19) stands out because of the pandemic situation started in 2020 [ 95 , 96 ].…”

Section: Resultsmentioning

confidence: 99%

Unraveling the MnMoO4 polymorphism: a comprehensive DFT investigation of α, β, and ω phases

Lacerda

San-Miguel

2022

J Mater Sci

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The MnMoO 4 is an environmentally friendly semiconductor material widely employed in technological devices. This material can be obtained on three different polymorphs, and although such phases were reported decades ago, some obscurity over their structure and properties is still perceived. Thus, this work provides a comprehensive DFT investigation of the α, β, and ω phases of MnMoO 4, analyzing their crystalline structure, stability, and electronic and magnetic properties. The results show that all phases of MnMoO 4 are stable at room conditions connected by pressure application or long-time high-temperature treatment. The MnMoO 4 phases are G-type antiferromagnetic with semiconductor bandgap and have enormous potential to develop magnetic, optical, and electronic devices and photocatalytic-based processes. The results also evidence potential antiviral and antibacterial activities of the three MnMoO 4 polymorphs. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s10853-022-07277-7.

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“…Quan and colleagues ( 84 ) tested functionalization of a surgical mask with a sodium chloride salt coating that dissolved on exposure to virus aerosol and recrystallized during drying; such filters showed better filtration than conventional masks and all mice survived influenza virus penetration through the rough salt-coated filters. It has been proposed that purposefully engineered materials with nanostructured surfaces can eliminate enveloped viruses such as SARS-CoV-2 i.a., on masks and be self-disinfectant ( 85 ). Other ways in which materials technology can improve masks is exemplified by a mask under development that lets some SARS-CoV-2 penetrate the mask, but heat-inactivates it ( 86 ).…”

Section: Discussionmentioning

confidence: 99%

Challenges and Controversies in COVID-19: Masking the General Population may Attenuate This Pandemic's Outbreak

Johansson

2021

Front. Public Health

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SARS-CoV-2, the virus that causes COVID-19, spreads i. a., by respiratory droplets. The use of masks in preventing spread is controversial; masks are considered useless by many, while being mandated in some locations. Here, the effect of masking the general population on a COVID-19-like epidemic is estimated by computer simulation using three separate types of software. The main questions are whether mask use by the general population can limit the spread of SARS-CoV-2 in a country and how to identify opportunities when mask use is cost-effective and safe. To address these questions, the protective effects of different types of masks, the side-effects of masks, and avenues for improvements of masks and masking are addressed. Main results: (i) Any type of mask, even simple home-made ones, may be of value, even if the protective effect of each mask (here dubbed “one mask-protection”) is low. Strict adherence to mask use does not appear to be critical but increasing one mask-protection to >50% was found to be advantageous. (ii) Masks do seem to reduce the number of new cases even if introduced at a late stage in an epidemic, but early implementation helps reduce the cumulative and total number of cases. (iii) The simulations suggest that it might be possible to eliminate a COVID-19 outbreak by widespread mask use during a limited period. There is a brief discussion of why the reported effect size of masking varies widely, and is expected to do so, because of different filtration abilities of different masks, differences in compliance and fitting, other routes of transmission, pre-existing immunity, and because a system of interconnected, disease-prone individuals has non-linear properties. A software solution to visualize infection spread is presented. The results from these simulations are encouraging, but do not necessarily represent the real-life situation, so it is suggested that clinical trials of masks are now carried out while continuously monitoring effects and side-effects. As mask use is not without risks and costs, it is suggested that governments and scientists have an important role in advising the public about the sensible use of masks.

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Promising Nanostructured Materials against Enveloped Virus

Cited by 17 publications

References 117 publications

Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived Drugs

Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived Drugs

Unraveling the MnMoO4 polymorphism: a comprehensive DFT investigation of α, β, and ω phases

Challenges and Controversies in COVID-19: Masking the General Population may Attenuate This Pandemic's Outbreak

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