Indigenous empowerment is a process of recognizing and supporting the rights, knowledge, and self-determination of indigenous communities. It acknowledges their unique perspectives, cultural heritage, and sustainable practices that have sustained their communities for generations. This chapter explores the challenges and importance of indigenous empowerment for achieving sustainable development and fostering a more inclusive and equitable society. This empowerment is not just about justice and rights but a strategic path to sustainable development. Collaborative partnerships among indigenous groups, governments, civil societies, and stakeholders are vital for promoting empowerment and addressing indigenous peoples' interconnected challenges. This chapter highlighted successful initiatives led by indigenous communities with significant progress in advancing the SDGs and fostering genuine partnerships that respect indigenous knowledge and promote cultural diversity is crucial for sustainable development that leaves no one behind.