Prompt detection of endogenous hypochlorite (ClO⁻) in murine macrophages and zebrafish embryos facilitated by a distinctive chemodosimetric mode

Abstract

An innovative Fluorescein appended naphthalene diimide based probe (FANDI) has been prepared and characterized to recognize hypochlorite or ClO- ion selectively in the presence of other reactive oxygen species (ROS)...

Fluorescein Hydrazide-Appended Metal–Organic Framework as a Chromogenic and Fluorogenic Chemosensor for Mercury Ions

“…The reaction mixture was refluxed for 4 h and then cooled to room temperature, poured into distilled water, and extracted with ethyl acetate (6 × 25 mL). The combined extract was washed with brine, dried with anhydrous sodium sulphate, filtered, and then concentrated under a reduced pressure to yield (71%) FH [52,53]. 1 H NMR (400 MHz, DMSO-d 6 ), δ (ppm): 6.47-6.39 (m, 4H), 6.60 (d, J= 3.0 Hz, 2H), 7.00-6.98 (m, 1H), 7.49 (t, J= 4.0 Hz, 2H), 7.79-7.77 (m, 1H), 9.84 (s, 2H).…”

Ruthenium(II) Complex‐based Highly Specific Luminescence Light‐up Probe for Detecting HOCl via C(sp2)‐H Chlorination

“…Compared to the several analytical methods, [18][19][20][21][22] luminescent detection possesses promising features because of excellent selectivity, sensitivity, simple operation, and in vitro and in vivo HOCl imaging. [13,16,17,[23][24][25][26] Consequently, many luminescent probes have been developed for specific detection and imaging of HOCl. [16][17][18][19][20][21][22][23][24][25][26][27][28] To date, most of the fluorescent HOCl probes were designed based on the strong oxidation property of HOCl, such as oxidation of chalcogenides, p-methoxyphenol, BÀ H bond, pyrrole ring, and deoximation reactions.…”

“…[13,16,17,[23][24][25][26] Consequently, many luminescent probes have been developed for specific detection and imaging of HOCl. [16][17][18][19][20][21][22][23][24][25][26][27][28] To date, most of the fluorescent HOCl probes were designed based on the strong oxidation property of HOCl, such as oxidation of chalcogenides, p-methoxyphenol, BÀ H bond, pyrrole ring, and deoximation reactions. [29][30][31][32][33][34][35][36][37][38][39] Few probes have also been established for HOCl via epoxidation of acyclic C=C bond, [40,41] leading to the formation of the corresponding aldehyde.…”

“…Thus, highly selective and sensitive detection of HOCl has received great importance in chemistry and biology. Compared to the several analytical methods, [18–22] luminescent detection possesses promising features because of excellent selectivity, sensitivity, simple operation, and in vitro and in vivo HOCl imaging [13,16,17,23–26] . Consequently, many luminescent probes have been developed for specific detection and imaging of HOCl [16–28] .…”