Proof-of-concept: Interfacing the liquid sampling-atmospheric pressure glow discharge ion source with a miniature quadrupole mass spectrometer towards trace metal analysis in cell culture media

Hoegg, Edward D.; Patel, Bhumit A.; Napoli, William; Richardson, Douglas D.; Marcus, R. Kenneth

doi:10.1039/c8ja00278a

Cited by 9 publications

(2 citation statements)

References 23 publications

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“…The interfacing of the LS‐APGD has been affected on two different single‐quadrupole platforms (Hall et al, 2021; Hoegg, Patel, et al, 2018; Williams & Marcus, 2020). In both instances, the practical driving force was the ability to perform elemental analyses in the biopharmaceutical production laboratory.…”

Section: Instrumentationmentioning

confidence: 99%

“…Thus, small, simple, low operational overhead instrumentation was desired versus transporting samples to ICP‐MS instrumentation at physically distant laboratories/facilities. The first demonstration was on a Waters QDa system (Hoegg, Patel, et al, 2018), which is typically part of a comprehensive LC/MS instrument, employing ESI analysis. The results showed that the LS‐APGD could deliver target performance for metals in bioreactor feed media, though use of a single quadrupole does yield complex mass spectra.…”

Section: Instrumentationmentioning

confidence: 99%

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Combined atomic and molecular (CAM) ionization with the liquid sampling‐atmospheric pressure glow discharge microplasma

Marcus

Hoegg

Hall

et al. 2021

Mass Spectrometry Reviews

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In a world where information‐rich methods of analysis are often sought over those with superior figures of merit, there is a constant search for ionization methods which can be applied across diverse analytical systems. The liquid sampling‐atmospheric pressure glow discharge (LS‐APGD) is a microplasma device which has the inherent capabilities to operate as a combined atomic and molecular (CAM) ionization source. The plasma is sustained by placement of a high voltage (~500 V, dc) onto an electrolytic solution through which the analyte is generally delivered to the discharge. Judicious choice of the solvent provides a means of obtaining atomic/elemental and/or molecular mass spectra. Presented here are the diverse modes of sample introduction and mass spectrometer platforms to which the LS‐APGD has been interfaced. Likewise, representative spectra and figures of merit are presented towards elemental and isotope ratio measurements, as well as application to small organic molecules, organometallic complexes, and intact proteins. It is believed that the diversity of analytical applications and ready implementation across the entirety of mass spectrometry platforms portends a level of versatility not realized with other ionization sources.

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Section: Instrumentationmentioning

confidence: 99%

Section: Instrumentationmentioning

confidence: 99%