1955
DOI: 10.1126/science.122.3169.545
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Properdin System and Immunity: II. Interaction of the Properdin System with Polysaccharides

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Cited by 226 publications
(66 citation statements)
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“…Cell-wall LPS from wild-type serum-resistant Gram-negative enteric bacteria such as Salmonella is structurally and functionally composed of 3 parts: the toxic lipid A region, the common core polysaccharide, and the O antigen-specific polysaccharide (40). With regard to complement, Pillemer et al (41) originally suggested that LPS activates the properdin system, now known as the alternative pathway, without involvement of antibodies. It was later shown that the classical pathway as well as the alternative pathway is involved in complement activation by LPS, with the polysaccharide part being responsible for alternative pathway activation (42).…”
Section: Discussionmentioning
confidence: 99%
“…Cell-wall LPS from wild-type serum-resistant Gram-negative enteric bacteria such as Salmonella is structurally and functionally composed of 3 parts: the toxic lipid A region, the common core polysaccharide, and the O antigen-specific polysaccharide (40). With regard to complement, Pillemer et al (41) originally suggested that LPS activates the properdin system, now known as the alternative pathway, without involvement of antibodies. It was later shown that the classical pathway as well as the alternative pathway is involved in complement activation by LPS, with the polysaccharide part being responsible for alternative pathway activation (42).…”
Section: Discussionmentioning
confidence: 99%
“…This was found to be due to the property of R lipopolysaccharides to reaggregate into a large-molecular-weight form through absorption of Mg2+ and Ca2+ present in the guinea pig serum used as complement source. Defective lipopolysaccharides derived from the Ra and Rb classes showed only negligible anti-complementary activity which did not increase by conversion into salt forms with high molecular weight.Many lipopolysaccharides interact with complement in vitro leading to loss of complement hemolytic activity [1,2]. This property is embedded in the lipid A part of the molecule and is expressed only by soluble lipopolysaccharides [ 2 ] .…”
mentioning
confidence: 99%
“…Many lipopolysaccharides interact with complement in vitro leading to loss of complement hemolytic activity [1,2]. This property is embedded in the lipid A part of the molecule and is expressed only by soluble lipopolysaccharides [ 2 ] .…”
mentioning
confidence: 99%
“…Pillemer et al (1955) demonstrated that the essential activity of zymosan consists in a glucan-rich fraction. In contrast, the mannan-rich fraction-glucomannan proteinshowed little activity.…”
Section: Introductionmentioning
confidence: 99%