Increasing the strength of foam glass to values sufficient for using it not only as a heat-insulating but also a structural material will significantly expand the scope of its application and reduce the material intensity of construction. The solution is possible due to the formation of a controlled and predictable heterogeneous amorphous-crystalline structure. The effect of the crystalline phase on the structure and strength of foam glass is contradictory and requires significant attention. At the same time, it is necessary to take into account the already obtained research results on reducing the cost of the material due to the use of waste. However, the composition of waste from various landfills varies, so a universal methodology for the development of materials is needed. A unified methodology is proposed that allows solving the problem of designing new materials using waste of various compositions, special attention is paid to the problem of synthesizing the composition of the initial batch and the temperature-time mode of foam glass synthesis. To confirm the proposed methodology, the material was developed using the example of ash and slag mixture of the TPP in Novocherkassk. The obtained foam glass samples and the research results were used to establish the features of the processes of formation of the foam glass microstructure using the regression analysis method.